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Ehrlichiosis–a disease of animals and humans.
Abstract: Ehrlichiae are one of several kinds of obligate intracellular bacteria. Taxonomically, they are grouped with rickettsiae, but they can be distinguished by their unique tropism for circulating leukocytes. Ehrlichia canis causes a pancytopenia in dogs that becomes chronic if untreated. Certain breeds develop severe infections, characterized by fever, anorexia, dramatic weight loss, marked pancytopenia, anemia, peripheral edema, and hemorrhage. Ehrlichia risticii, a recently discovered species, is the cause of a serious diarrheal disease of horses. Other species of ehrlichiae have been documented as being veterinary pathogens. Recent data indicate that E. canis or a closely related species causes an acute febrile illness in humans. Clinically, the disease is similar to Rocky Mountain spotted fever, except that most patients do not have a rash. Human ehrlichiosis appears to be tickborne and is prevalent primarily in the southern Atlantic and south-central states. A mild from of ehrlichiosis has also been documented.
Publication Date: 1990-04-01 PubMed ID: 2181027DOI: 10.1093/infdis/161.4.609Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Review
- Diagnosis
- Disease
- Disease control
- Disease Diagnosis
- Disease Etiology
- Disease Management
- Disease Outbreaks
- Disease Prevalence
- Disease Surveillance
- Disease Transmission
- Disease Treatment
- Equine Health
- Horses
- Infection
- Infectious Disease
- Public Health
- Tick-Borne Diseases
- Vector-borne disease
- Veterinary Medicine
- Zoonotic Diseases
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research article discusses the disease Ehrlichiosis, which affects both animals and humans. The primary agent causing the disease is Ehrlichiae, a type of bacteria that nest in circulating leukocytes. Several variations of the disease exist in animals, such as those affecting dogs and horses, with symptoms ranging from marked pancytopenia to severe infections. Recent evidence suggests that humans can also be affected, exhibiting symptoms similar to Rocky Mountain spotted fever.
Understanding Ehrlichiosis
Ehrlichiosis is a disease caused by the Ehrlichia bacteria, which belongs to the taxonomic group of obligate intracellular bacteria – types of bacteria that can only survive within the cells of a host organism. Ehrlichiae share some similarities with Rickettsiae (another bacteria group), but their distinguishing feature lies in their tropism for circulating leukocytes; that is, their preference to inhabit white blood cells.
- The study reviews the different types of Ehrlichia that cause diseases in animals and humans.
- For instance, Ehrlichia canis can result in pancytopenia (a reduction in the number of red and white blood cells as well as platelets) in dogs. If this is left untreated, it could lead to chronic conditions.
- Certain breeds of dogs are more susceptible to developing severe infections, which are marked by a range of symptoms, including fever, anorexia, considerable weight loss, marked pancytopenia, anemia, swelling in the peripheral regions, and hemorrhage (bleeding).
- Another strain, Ehrlichia risticii, has been found to cause a serious diarrheal condition in horses.
- Other species of Ehrlichia have also been found to be pathogenic in animals.
Ehrlichiosis in Humans
Besides animals, humans are also susceptible to this bacterial infection.
- Recent studies suggest that E. canis or a related species can cause an acute febrile (feverish) illness in humans. The symptoms resemble those of Rocky Mountain spotted fever, another bacterial disease, but most patients do not exhibit a rash, differentiating the two conditions.
- Human Ehrlichiosis seems to be transmitted by ticks and is primarily prevalent in the southern Atlantic and south-central states of the U.S.
- There is also evidence of a milder strain of Ehrlichiosis, though further details are not presented in the abstract.
Cite This Article
APA
McDade JE.
(1990).
Ehrlichiosis–a disease of animals and humans.
J Infect Dis, 161(4), 609-617.
https://doi.org/10.1093/infdis/161.4.609 Publication
Researcher Affiliations
- Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 30333.
MeSH Terms
- Animals
- Dog Diseases / epidemiology
- Dog Diseases / microbiology
- Dogs
- Ehrlichia / ultrastructure
- Horse Diseases / epidemiology
- Horse Diseases / microbiology
- Horses
- Humans
- Leukocytes / microbiology
- Rickettsiaceae Infections / epidemiology
- Rickettsiaceae Infections / microbiology
- Rickettsiaceae Infections / veterinary
- United States / epidemiology
Citations
This article has been cited 26 times.- Whelchel BD, Palerme JS, Tou SP, Ward JL. Retrospective evaluation of the etiology and clinical characteristics of peripheral edema in dogs. J Vet Intern Med 2023 Sep-Oct;37(5):1725-1737.
- Roy S, Nag S, Saini A, Choudhury L. Association of human gut microbiota with rare diseases: A close peep through. Intractable Rare Dis Res 2022 May;11(2):52-62.
- Ybañez RHD, Ybañez AP, Arnado LLA, Belarmino LMP, Malingin KGF, Cabilete PBC, Amores ZRO, Talle MG, Liu M, Xuan X. Detection of Ehrlichia, Anaplasma, and Babesia spp. in dogs of Cebu, Philippines. Vet World 2018 Jan;11(1):14-19.
- Fischer K, Tkach VV, Curtis KC, Fischer PU. Ultrastructure and localization of Neorickettsia in adult digenean trematodes provides novel insights into helminth-endobacteria interaction. Parasit Vectors 2017 Apr 13;10(1):177.
- Ybañez AP, Ybañez RH, Villavelez RR, Malingin HP, Barrameda DN, Naquila SV, Olimpos SM. Retrospective analyses of dogs found serologically positive for Ehrlichia canis in Cebu, Philippines from 2003 to 2014. Vet World 2016 Jan;9(1):43-7.
- Ganta RR, Peddireddi L, Seo GM, Dedonder SE, Cheng C, Chapes SK. Molecular characterization of Ehrlichia interactions with tick cells and macrophages. Front Biosci (Landmark Ed) 2009 Jan 1;14(9):3259-73.
- Chapes SK, Ganta RR. Defining the immune response to Ehrlichia species using murine models. Vet Parasitol 2008 Dec 20;158(4):344-59.
- Drevets DA, Leenen PJ, Greenfield RA. Invasion of the central nervous system by intracellular bacteria. Clin Microbiol Rev 2004 Apr;17(2):323-47.
- Olano JP, Masters E, Hogrefe W, Walker DH. Human monocytotropic ehrlichiosis, Missouri. Emerg Infect Dis 2003 Dec;9(12):1579-86.
- Paddock CD, Childs JE. Ehrlichia chaffeensis: a prototypical emerging pathogen. Clin Microbiol Rev 2003 Jan;16(1):37-64.
- Inokuma H, Brouqui P, Drancourt M, Raoult D. Citrate synthase gene sequence: a new tool for phylogenetic analysis and identification of Ehrlichia. J Clin Microbiol 2001 Sep;39(9):3031-9.
- Sreekumar C, Anandan R, Balasundaram S, John L. Detection of an Ehrlichia bovis-like organism in cultured buffalo monocytes. Trop Anim Health Prod 2000 Apr;32(2):67-72.
- Ohashi N, Unver A, Zhi N, Rikihisa Y. Cloning and characterization of multigenes encoding the immunodominant 30-kilodalton major outer membrane proteins of Ehrlichia canis and application of the recombinant protein for serodiagnosis. J Clin Microbiol 1998 Sep;36(9):2671-80.
- Lockhart JM, Davidson WR, Stallknecht DE, Dawson JE, Howerth EW. Isolation of Ehrlichia chaffeensis from wild white-tailed deer (Odocoileus virginianus) confirms their role as natural reservoir hosts. J Clin Microbiol 1997 Jul;35(7):1681-6.
- Magnarelli LA, Stafford KC 3rd, Mather TN, Yeh MT, Horn KD, Dumler JS. Hemocytic rickettsia-like organisms in ticks: serologic reactivity with antisera to Ehrlichiae and detection of DNA of agent of human granulocytic ehrlichiosis by PCR. J Clin Microbiol 1995 Oct;33(10):2710-4.
- Brouqui P, Birg ML, Raoult D. Cytopathic effect, plaque formation, and lysis of Ehrlichia chaffeensis grown on continuous cell lines. Infect Immun 1994 Feb;62(2):405-11.
- Magnarelli LA, Anderson JF. Serologic evidence of canine and equine ehrlichiosis in northeastern United States. J Clin Microbiol 1993 Nov;31(11):2857-60.
- Rikihisa Y, Ewing SA, Fox JC. Western immunoblot analysis of Ehrlichia chaffeensis, E. canis, or E. ewingii infections in dogs and humans. J Clin Microbiol 1994 Sep;32(9):2107-12.
- Barton LL. Therapy of human ehrlichiosis reconsidered. Antimicrob Agents Chemother 1991 Feb;35(2):398.
- Rikihisa Y. The tribe Ehrlichieae and ehrlichial diseases. Clin Microbiol Rev 1991 Jul;4(3):286-308.
- McDade JE. Diagnosis of rickettsial diseases: a perspective. Eur J Epidemiol 1991 May;7(3):270-5.
- Hof H. Microbial strategies for intracellular survival. Infection 1991;19 Suppl 4:S202-5.
- Magnarelli LA, Andreadis TG, Stafford KC 3rd, Holland CJ. Rickettsiae and Borrelia burgdorferi in ixodid ticks. J Clin Microbiol 1991 Dec;29(12):2798-804.
- Dawson JE, Anderson BE, Fishbein DB, Sanchez JL, Goldsmith CS, Wilson KH, Duntley CW. Isolation and characterization of an Ehrlichia sp. from a patient diagnosed with human ehrlichiosis. J Clin Microbiol 1991 Dec;29(12):2741-5.
- Dunn BE, Monson TP, Dumler JS, Morris CC, Westbrook AB, Duncan JL, Dawson JE, Sims KG, Anderson BE. Identification of Ehrlichia chaffeensis morulae in cerebrospinal fluid mononuclear cells. J Clin Microbiol 1992 Aug;30(8):2207-10.
- Armstrong RW. Ehrlichiosis in a visitor to Virginia. West J Med 1992 Aug;157(2):182-4.
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