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The Journal of clinical investigation1974; 53(1); 310-319; doi: 10.1172/JCI107552

Electrical dose for ventricular defibrillation of large and small animals using precordial electrodes.

Abstract: Electrical ventricular defibrillation of heavy subjects (over 100 kg body weight) is uncommon for the human or any animal species. This paper reports trans-chest ventricular defibrillation of subjects ranging in weight from 2.3 to 340 kg using conventional defibrillation current (heavily damped sine wave) of 0.3-30 ms duration. It was found that a body weight-to-electrical-shock strength relationship exists and can be expressed in terms of either electrical energy or peak current. For the duration of current pulse used clinically (3-10 ms), the relationship between energy requirement and body weight is expressed by the equation U = 0.73 W(1.52), where U is the energy in W.s and W is the body weight in kilograms. The current relationship is I = 1.87 W(0.88) where I is the peak current in amperes and W is the body weight in kilograms. The energy dose is somewhat more species and weight dependent and ranges from 0.5 to 10 W.s/kg (0.23-4.5 W.s/lb). The data obtained indicate that the peak current dose is virtually species and weight independent and is therefore a better indicator than energy for electrical defibrillation with precordial electrodes. In the duration range of 3-10 ms, the electrical dose is very nearly 1 A/kg of body weight (0.45 A/lb).
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Publication Date: 1974-01-01 PubMed ID: 4808643PubMed Central: PMC301466DOI: 10.1172/JCI107552Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study discusses the relationship between the electrical shock strength needed for effective ventricular defibrillation and the body weight of the subject, findings of which could significantly guide clinical applications of defibrillation across different body weights and species.

Background of the Study

  • The research specifically undertakes the investigation of the ability to accomplish ventricular defibrillation (a process where an electrical shock is given to the heart to reset its rhythm) on subjects ranging from body weight 2.3 kg to 340 kg.
  • This addresses a gap in the existing knowledge as subjects of high body-weight, above 100kg, are not common objects of such studies.

Methods Employed

  • The researchers employ the use of conventional defibrillation current in a heavily damped sine wave format with a duration of 0.3-30 ms for this study.

Key Findings

  • The results of this experiment demonstrated that there is indeed a relationship between body weight and the required electrical shock strength for effective ventricular defibrillation.
  • This relationship is confirmed to exist when shock strength is measured in terms of both electrical energy and peak current.
  • The study postulates two key equations to determine the energy requirement and peak current respectively based on the weight of the subject. They are: U = 0.73 W(1.52) for determining energy where, U is the energy in W.s and W is the weight in kilograms. And, I = 1.87 W(0.88) for calculating peak current where, I is the peak current in amperes and W represents the weight in kilograms.
  • In terms of the energy dose, a range of 0.5 to 10 W.s/kg (or 0.23-4.5 W.s/lb when weight is measured in pounds) was found to be more dependent on species and weight of the subject.
  • Contrarily, the peak current dose appears to be more or less independent of species and weight which indicates its potential as a better indicator than energy for effective electrical defibrillation with precordial electrodes.
  • The researchers approximate the electrical dose within the pulse duration range of 3-10 ms to be about 1 A/kg of body weight or 0.45 A/lb.

Implications of the Study

  • The study outcomes can be useful in providing an evidence-based guide to clinicians for applying electrical defibrillation based on varying body weights and species, to ensure optimal results.

Cite This Article

APA
Geddes LA, Tacker WA, Rosborough JP, Moore AG, Cabler PS. (1974). Electrical dose for ventricular defibrillation of large and small animals using precordial electrodes. J Clin Invest, 53(1), 310-319. https://doi.org/10.1172/JCI107552

Publication

The Journal of clinical investigation
ISSN: 0021-9738
NlmUniqueID: 7802877
Country: United States
Language: English
Volume: 53
Issue: 1
Pages: 310-319

Researcher Affiliations

Geddes, L A
    Tacker, W A
      Rosborough, J P
        Moore, A G
          Cabler, P S

            MeSH Terms

            • Animals
            • Body Weight
            • Dogs
            • Electric Countershock
            • Electrodes
            • Goats
            • Heart
            • Horses
            • Methods
            • Organ Size
            • Rabbits

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