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The Journal of antimicrobial chemotherapy2018; 73(4); 867-872; doi: 10.1093/jac/dkx489

Emergence of blaCTX-M-55 associated with fosA, rmtB and mcr gene variants in Escherichia coli from various animal species in France.

Abstract: In Asian countries, blaCTX-M-55 is the second most common ESBL-encoding gene. blaCTX-M-55 frequently co-localizes with fosA and rmtB genes on epidemic plasmids, which remain sporadic outside Asia. During 2010-13, we investigated CTX-M-55-producing Escherichia coli isolates and their co-resistance to fosfomycin, aminoglycosides, fluoroquinolones and colistin as part of a global survey of ESBLs in animals in France. blaCTX-M-55, fosA, rmtB and plasmidic quinolone and colistin resistance genes were characterized by PCR, sequencing and hybridization experiments. Plasmids were classified according to their incompatibility groups and subtypes. Genotyping was performed by MLST and repetitive extragenic palindromic sequence-based PCR. Twenty-one E. coli isolates from bovines (n = 16), dogs (n = 2), horses (n = 2) and a monkey harboured blaCTX-M-55, were MDR and belonged to ST744 (n = 9) and 10 other clones. blaCTX-M-55 was mostly located on IncF (n = 19), but also on IncI1 (n = 2) plasmids. On IncF33:A1:B1 plasmids, blaCTX-M-55 co-localized with the rmtB and aac(6')-Ib genes and in one isolate with the fosA3 allele. Ten IncF46:A-:B20 plasmids, which were found in different clones from unrelated animals, also carried the mcr-3 gene. blaCTX-M-55-carrying IncF18:A-:B1 plasmids were found in different animal species from distinct locations and periods, and one additionally carried the fosA4 gene. One isolate harboured the mcr-1 gene, which did not co-localize with blaCTX-M-55. A large diversity of E. coli clones and plasmid types supported the spread of blaCTX-M-55, together with atypical resistance genes, in various animal species in France. fosA and rmtB genes are emerging among animals in Europe and this issue is of concern for public health.
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Publication Date: 2018-01-18 PubMed ID: 29340602DOI: 10.1093/jac/dkx489Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article focuses on the emergence of the blaCTX-M-55 gene in Escherichia coli isolates from various animal species in France, investigating instances of co-resistance to several types of antibiotics. Throughout their study, the researchers found a wide diversity of E. coli clones and plasmids responsible for spreading the blaCTX-M-55 gene, along with other unconventional resistance genes.

Research Methodology

  • The researchers conducted a thorough examination of CTX-M-55-producing E. coli isolates in animals from 2010 to 2013, across France. They also looked for co-resistance to other antibiotics like fosfomycin, aminoglycosides, fluoroquinolones, and colistin.
  • The characterization of blaCTX-M-55, fosA, rmtB and plasmidic quinolone, and colistin resistance genes was done through methods like PCR (Polymerase Chain Reaction), sequencing, and hybridization experiments.
  • The plasmids, which are independent genetic structures in cells capable of replication, were categorized based on their incompatibility groups and subtypes.
  • Genotyping of the isolates was carried out using MLST (Multi Locus Sequence Typing) and repetitive extragenic palindromic sequence-based PCR.

Research Findings

  • The investigators identified twenty-one E. coli isolates from different animals- bovines, dogs, horses, and a monkey- that carried the blaCTX-M-55 gene. These isolates were multi-drug resistant (MDR) and connected to the clone ST744 and ten other clones.
  • The blaCTX-M-55 gene was primarily found on IncF plasmids, and to a lesser extent on IncI1 plasmids. When present on IncF33:A1:B1 plasmids, the blaCTX-M-55 gene typically co-localized with the rmtB and aac(6′)-Ib genes, another gene, fosA3, was also co-localized in one isolate.
  • The blaCTX-M-55 gene was also found on blaCTX-M-55-carrying IncF18:A-:B1 plasmids in different animal species from various locations and time periods. Plasmid IncF18:A-:B1 also carried the fosA4 gene in one distinct instance.
  • One isolate was found to harbour the mcr-1 gene that did not co-localize with the blaCTX-M-55 gene.

Conclusions and Public Health Implications

  • The research discovered a considerable diversity of E. coli clones and plasmid types instrumental in amplifying the spread of the blaCTX-M-55 gene, alongside other non-typical resistance genes, across various animal species in France.
  • Additionally, the study emphasized that the fosA and rmtB genes are progressively emerging among animal populations in Europe, presenting concerning implications for public health, as this development could challenge the efficacy of existing antibiotic treatments.

Cite This Article

APA
Lupo A, Saras E, Madec JY, Haenni M. (2018). Emergence of blaCTX-M-55 associated with fosA, rmtB and mcr gene variants in Escherichia coli from various animal species in France. J Antimicrob Chemother, 73(4), 867-872. https://doi.org/10.1093/jac/dkx489

Publication

The Journal of antimicrobial chemotherapy
ISSN: 1460-2091
NlmUniqueID: 7513617
Country: England
Language: English
Volume: 73
Issue: 4
Pages: 867-872

Researcher Affiliations

Lupo, Agnese
  • Université de Lyon - ANSES, Unité Antibiorésistance et Virulence Bactériennes, Lyon, France.
Saras, Estelle
  • Université de Lyon - ANSES, Unité Antibiorésistance et Virulence Bactériennes, Lyon, France.
Madec, Jean-Yves
  • Université de Lyon - ANSES, Unité Antibiorésistance et Virulence Bactériennes, Lyon, France.
Haenni, Marisa
  • Université de Lyon - ANSES, Unité Antibiorésistance et Virulence Bactériennes, Lyon, France.

MeSH Terms

  • Animals
  • Cattle
  • Dogs
  • Drug Resistance, Bacterial
  • Escherichia coli / drug effects
  • Escherichia coli / genetics
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / microbiology
  • Escherichia coli Infections / veterinary
  • Escherichia coli Proteins / genetics
  • France
  • Genotype
  • Genotyping Techniques
  • Haplorhini
  • Horses
  • Methyltransferases / genetics
  • Multilocus Sequence Typing
  • Nucleic Acid Hybridization
  • Plasmids / analysis
  • Plasmids / classification
  • Polymerase Chain Reaction
  • Sequence Analysis, DNA
  • beta-Lactamases / genetics

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