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The Veterinary clinics of North America. Equine practice2010; 26(2); 233-237; doi: 10.1016/j.cveq.2010.04.009

Endocrinopathic laminitis.

Abstract: In laminitis occurring in the field, as opposed to laminitis occurring during hospitalization or severe illness, endocrinopathic laminitis is the predominant form of laminitis. Prevalent causes of endocrinopathic laminitis are ECS and EMS. Exclusion of inflammatory or weight bearing causes of laminitis and focussing on the identification and treatment of underlying endocrine conditions will improve laminitis management strategies.
Publication Date: 2010-06-11 PubMed ID: 20699171DOI: 10.1016/j.cveq.2010.04.009Google Scholar: Lookup
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Summary

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The research article details how endocrinopathic laminitis, a form of laminitis commonly found in field conditions, is predominantly caused by Equine Cushing’s Syndrome (ECS) and Equine Metabolic Syndrome (EMS). The paper emphasizes improving laminitis management strategies by identifying and treating these underlying endocrine conditions rather than focusing on inflammatory or weight-bearing causes.

Introduction

The research focuses on endocrinopathic laminitis, a specific type of laminitis which is largely identified in field conditions as opposed to those occurring during hospitalization or during severe illness. The paper highlights the common causes of this type of laminitis – Equine Cushing’s Syndrome (ECS) and Equine Metabolic Syndrome (EMS).

The role of Equine Cushing’s Syndrome and Equine Metabolic Syndrome

  • The paper emphasizes ECS and EMS as primary causes of endocrinopathic laminitis, dismissing weight bearing or inflammatory causes as major contributing factors. ECS is a disorder prominent in horses caused by the formation of a tumour in the pituitary gland which leads to excessive production of certain hormones. This hormonal imbalance can cause severe conditions such as laminitis.
  • Similarly, EMS is another metabolic disorder found in equines that can lead to obesity, insulin resistance and laminitis. The study identifies these endocrine conditions as major contributors to the on-set of laminitis in horses in field conditions.

Improving laminitis management strategies

  • The researchers argue for a shift in focus when it comes to treating laminitis, advocating the identification and treatment of underlying endocrine conditions like ECS and EMS rather that concentrating on inflammatory or weight bearing causes.
  • The essence of this conclusion lies in the observation that successfully treating ECS and EMS can improve the overall condition of the horse, significantly reducing the impact of laminitis.

Cite This Article

APA
McGowan CM. (2010). Endocrinopathic laminitis. Vet Clin North Am Equine Pract, 26(2), 233-237. https://doi.org/10.1016/j.cveq.2010.04.009

Publication

ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 26
Issue: 2
Pages: 233-237

Researcher Affiliations

McGowan, Catherine M
  • School of Veterinary Science, Faculty of Health and Life Sciences, University of Liverpool, Leahurst, UK. C.M.Mcgowan@liverpool.ac.uk

MeSH Terms

  • Animals
  • Endocrine System Diseases / complications
  • Endocrine System Diseases / pathology
  • Endocrine System Diseases / veterinary
  • Foot Diseases / etiology
  • Foot Diseases / pathology
  • Foot Diseases / veterinary
  • Hoof and Claw
  • Horse Diseases / etiology
  • Horse Diseases / pathology
  • Horses
  • Inflammation / veterinary

Citations

This article has been cited 8 times.
  1. Aoun R, Charles I, DeRouen A, Takawira C, Lopez MJ. Shoe configuration effects on third phalanx and capsule motion of unaffected and laminitic equine hooves in-situ. PLoS One 2023;18(5):e0285475.
    doi: 10.1371/journal.pone.0285475pubmed: 37155654google scholar: lookup
  2. Stefanovski D, Robinson MA, Van Eps A. Effect of a GLP-1 mimetic on the insulin response to oral sugar testing in horses. BMC Vet Res 2022 Jul 29;18(1):294.
    doi: 10.1186/s12917-022-03394-2pubmed: 35906619google scholar: lookup
  3. de Laat MA, Sillence MN, Reiche DB. Phenotypic, hormonal, and clinical characteristics of equine endocrinopathic laminitis. J Vet Intern Med 2019 May;33(3):1456-1463.
    doi: 10.1111/jvim.15419pubmed: 30697823google scholar: lookup
  4. Baskerville CL, Chockalingham S, Harris PA, Bailey SR. The effect of insulin on equine lamellar basal epithelial cells mediated by the insulin-like growth factor-1 receptor. PeerJ 2018;6:e5945.
    doi: 10.7717/peerj.5945pubmed: 30519508google scholar: lookup
  5. Kheder MH, Bailey SR, Dudley KJ, Sillence MN, de Laat MA. Equine glucagon-like peptide-1 receptor physiology. PeerJ 2018;6:e4316.
    doi: 10.7717/peerj.4316pubmed: 29404215google scholar: lookup
  6. Hart KA, Wochele DM, Norton NA, McFarlane D, Wooldridge AA, Frank N. Effect of Age, Season, Body Condition, and Endocrine Status on Serum Free Cortisol Fraction and Insulin Concentration in Horses. J Vet Intern Med 2016 Mar-Apr;30(2):653-63.
    doi: 10.1111/jvim.13839pubmed: 26860336google scholar: lookup
  7. Lancaster LS, Bowker RM. Acupuncture Points of the Horse's Distal Thoracic Limb: A Neuroanatomic Approach to the Transposition of Traditional Points. Animals (Basel) 2012 Sep 17;2(3):455-71.
    doi: 10.3390/ani2030455pubmed: 26487033google scholar: lookup
  8. Davis EL, Wood AD, Potier JFN. Prevalence and Progression of Resting ACTH, Insulin and Adiponectin Values as Indicators of Suspected Endocrine Diseases in Sport Horses and Ponies Compared to Non-Sport Horses, Ponies and Donkeys. Animals (Basel) 2025 May 1;15(9).
    doi: 10.3390/ani15091316pubmed: 40362130google scholar: lookup