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The Veterinary clinics of North America. Equine practice2026; 42(3); 457-471; doi: 10.1016/j.cveq.2026.07.002

Endocrinopathic Laminitis.

Abstract: Endocrinopathic laminitis is a consequence of persistent hyperinsulinemia, therefore insulin control is the key to prevention and effective treatment. This form of laminitis is commonly subclinical and therefore early diagnosis requires metabolic screening to establish risk and radiographic screening to detect early laminitic changes that may not yet be clinically apparent. Management changes can be used in conjunction with medication to control insulin and effectively prevent and treat endocrinopathic laminitis.
Publication Date: 2026-08-12 PubMed ID: 42586915DOI: 10.1016/j.cveq.2026.07.002Google Scholar: Lookup
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Summary

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Endocrinopathic laminitis is a disease in horses caused by prolonged high insulin levels, and controlling insulin is crucial for prevention and treatment. Early detection through metabolic and radiographic screening helps identify at-risk animals before clinical signs appear, allowing for effective management and medication strategies.

Introduction to Endocrinopathic Laminitis

  • Endocrinopathic laminitis is a condition affecting the hooves of horses.
  • It results from persistent hyperinsulinemia, which means consistently high levels of insulin in the blood.
  • This condition is a metabolic disorder, linked to endocrine system dysfunction.

Pathophysiology and Cause

  • The primary cause of endocrinopathic laminitis is persistent hyperinsulinemia.
  • High insulin levels disrupt normal hoof tissue metabolism leading to laminitis.
  • Unlike other types of laminitis caused by inflammation or infection, this form is endocrine-driven.

Diagnosis

  • Often, endocrinopathic laminitis is subclinical, meaning signs may not be obvious initially.
  • Early diagnosis is crucial to prevent severe damage and involves metabolic screening.
  • Metabolic screening tests insulin and other related blood markers to assess risk.
  • Radiographic screening (imaging techniques such as X-rays) can detect early laminitic changes in the hoof before clinical symptoms become apparent.

Management and Treatment

  • The cornerstone of both prevention and treatment is controlling insulin levels.
  • Management changes include diet modifications such as reducing sugar and starch intake to lower insulin response.
  • Exercise and weight control are also important to improve insulin sensitivity.
  • Medications may be used alongside management strategies to aid in regulating blood insulin levels.
  • Effective control of insulin can prevent the onset or progression of laminitis and improve hoof health.

Summary

  • Endocrinopathic laminitis is a serious but often hidden condition linked to high insulin levels in horses.
  • Early detection through metabolic and radiographic screening is vital to reduce the risk of progression.
  • Combination of management strategies and medication targeting insulin control offers effective prevention and treatment.

Cite This Article

APA
van Eps AW. (2026). Endocrinopathic Laminitis. Vet Clin North Am Equine Pract, 42(3), 457-471. https://doi.org/10.1016/j.cveq.2026.07.002

Publication

ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 42
Issue: 3
Pages: 457-471
PII: S0749-0739(26)00049-0

Researcher Affiliations

van Eps, Andrew W
  • Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, 382 West Street Road, Kennett Square, PA 19348, USA. Electronic address: vaneps@upenn.edu.

MeSH Terms

  • Animals
  • Horse Diseases / diagnosis
  • Horse Diseases / etiology
  • Horse Diseases / pathology
  • Horse Diseases / therapy
  • Foot Diseases / veterinary
  • Foot Diseases / etiology
  • Foot Diseases / diagnosis
  • Foot Diseases / therapy
  • Foot Diseases / pathology
  • Horses
  • Hoof and Claw / pathology
  • Hyperinsulinism / veterinary
  • Hyperinsulinism / complications
  • Inflammation / veterinary
  • Inflammation / etiology

Conflict of Interest Statement

Disclosures No conflicts of interest to declare. The author is grateful to the Grayson Jockey Club Research Foundation and the Laminitis Research Fund (University of Pennsylvania) for funding past and present laminitis studies relevant to this review.

Citations

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