Endogenous plasma coenzyme Q10 concentration does not correlate with plasma total antioxidant capacity level in healthy untrained horses.

The research studied the relationship between Coenzyme Q10 (CoQ10), an important chemical compound, and the total antioxidant capacity in the blood of healthy horses. The findings revealed that there’s no significant correlation between the two.

Study Objective and Participants

The objective of this study was to determine the endogenous plasma concentration of CoQ10 in untrained healthy horses and analyze if there’s any correlation with their plasma total antioxidant capacity (TAC) level and serum total cholesterol (TC) level. For this purpose, thirty-one healthy and untrained horses were included as the study subjects.

• Endogenous plasma is the concentration of naturally occurring CoQ10 in the body.
• CoQ10 is a compound that naturally occurs in the body and plays a crucial role in the process of energy generation in cells. It is the only known lipid-soluble antioxidant synthesized in the body.
• Antioxidants inhibit oxidation in living cells.

Methodology and Findings

Plasma concentration of CoQ10 was measured in the horses and found to be between 0.380 to 2.090 mg/L, which aligns with the CoQ10 concentration typically found in humans.

• No significant correlation between CoQ10 and TAC was found. It implies that CoQ10 does not significantly contribute to the total antioxidant capacity of the plasma in horses.
• The relationship between CoQ10 and TC was also analyzed. Unlike in humans, the findings showed no significant correlation between these two variables in the horse population used in the study.

Implication of the Study

The results of the study suggest that despite CoQ10’s role as an endogenously synthesized lipid-soluble antioxidant, its contribution to the total antioxidant capacity in horse plasma is insignificant. There’s also no noticeable relationship between CoQ10 and total cholesterol levels in these untrained healthy horses. Therefore, the study recommends further research on CoQ10 supplementation in horses and its potential correlation with TAC.