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The Veterinary clinics of North America. Equine practice2016; 32(3); 465-480; doi: 10.1016/j.cveq.2016.08.004

Endometritis: Managing Persistent Post-Breeding Endometritis.

Abstract: Endometritis was rated as the third most common medical problem encountered in adult horses in North America. It is the leading cause of subfertility in broodmares and is a major contributor to economic loss in the horse breeding industry, with pregnancy rates reported to be as low as 21% in mares with severe endometritis. Endometritis may be categorized as: endometrosis (chronic degenerative endometritis), acute, chronic, active, dormant, subclinical, clinical, and persistent post-breeding. These classifications are not mutually exclusive, and mares may change categories within breeding seasons or estrous cycles or may fit in multiple classifications. This chapter will focus on discussing etiology and management strategies for mares affected by persistent post-breeding endometritis. Overall, these mares are considered subfertile but acceptable pregnancy and foaling rates can be achieved with appropriate breeding management.
Copyright © 2016 Elsevier Inc. All rights reserved.
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Publication Date: 2016-11-05 PubMed ID: 27810036DOI: 10.1016/j.cveq.2016.08.004Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses the causes and management strategies for mares affected by persistent post-breeding endometritis, a common reproductive problem in horses that significantly reduces fertility rates.

What is Endometritis?

  • Endometritis is one of the significant health issues in adult horses, particularly in North America, where it ranks third on the list of common medical problems.
  • This condition is a leading factor of subfertility in broodmares, greatly impacting the horse breeding industry. It has been observed that mares affected by severe endometritis show a drastically low pregnancy rate, sometimes as low as 21%.

Classifications of Endometritis

  • The researchers categorize Endometritis into several forms: endometrosis (chronic degenerative endometritis), acute, chronic, active, dormant, subclinical, clinical, and persistent post-breeding. The categorization is based on the nature, severity, and duration of the condition.
  • These classifications aren’t mutually exclusive, meaning a mare can exhibit symptoms of multiple categories, or her classification may change within breeding seasons or estrous cycles. This flexibility suggests the unpredictability and complexity of the disease.

Focus on Persistent Post-Breeding Endometritis

  • This specific study delves into understanding and managing a specific type of endometritis referred to as ‘persistent post-breeding endometritis.’ This is a condition manifested after breeding, which persists and thus often impairs fertility rates.
  • While mares with this condition are usually considered subfertile, the researchers are optimistic that with the right breeding protocols and management, acceptable pregnancy and foaling rates can potentially be achieved.

Importance of the Study

  • This research seeks to provide valuable insights into one of the challenging health conditions impacting the horse breeding industry. By identifying etiology and effective management strategies, it could contribute to reducing economic loss in the sector.
  • Designed to enhance understanding and practical handling of persistent post-breeding endometritis, this study could help breeders improve fertility rates in affected mares and eventually, breed healthier foals.

Cite This Article

APA
Canisso IF, Stewart J, Coutinho da Silva MA. (2016). Endometritis: Managing Persistent Post-Breeding Endometritis. Vet Clin North Am Equine Pract, 32(3), 465-480. https://doi.org/10.1016/j.cveq.2016.08.004

Publication

The Veterinary clinics of North America. Equine practice
ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 32
Issue: 3
Pages: 465-480
PII: S0749-0739(16)30043-8

Researcher Affiliations

Canisso, Igor F
  • Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois Urbana-Champaign, 2001 S Lincoln Ave, Urbana, IL 61822, USA.
Stewart, Jamie
  • Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois Urbana-Champaign, 2001 S Lincoln Ave, Urbana, IL 61822, USA.
Coutinho da Silva, Marco A
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon Tharp St, Columbus, OH 43210, USA. Electronic address: marco.dasilva@cvm.osu.edu.

MeSH Terms

  • Animals
  • Breeding
  • Endometritis / prevention & control
  • Endometritis / veterinary
  • Female
  • Horse Diseases / prevention & control
  • Horses
  • Pregnancy
  • Puerperal Infection / prevention & control
  • Puerperal Infection / veterinary

Citations

This article has been cited 24 times.
  1. Tyrnenopoulou P, Fthenakis GC. Clinical Aspects of Bacterial Distribution and Antibiotic Resistance in the Reproductive System of Equids. Antibiotics (Basel) 2023 Mar 28;12(4).
    doi: 10.3390/antibiotics12040664pubmed: 37107026google scholar: lookup
  2. Silva ESM, Newcombe JR, Cuervo-Arango J. The Effect of Treatment with Oestradiol Benzoate on Oestrus Expression and Endometrial Oedema in Anovulatory and Cyclic Mares. Animals (Basel) 2023 Mar 5;13(5).
    doi: 10.3390/ani13050938pubmed: 36899795google scholar: lookup
  3. Freccero F, Mislei B, Bucci D, Dondi F, Mari G. Effects of Intra-Uterine Fluid Accumulation after Artificial Insemination on Luteal Function in Mares. Animals (Basel) 2022 Dec 23;13(1).
    doi: 10.3390/ani13010067pubmed: 36611677google scholar: lookup
  4. D'Agostino A, Di Palma T, Cecchini Gualandi S, Boni R. Fluorescence Spectroscopy for the Diagnosis of Endometritis in the Mare. Animals (Basel) 2022 Apr 29;12(9).
    doi: 10.3390/ani12091157pubmed: 35565583google scholar: lookup
  5. Nocera FP, D'Eletto E, Ambrosio M, Fiorito F, Pagnini U, De Martino L. Occurrence and Antimicrobial Susceptibility Profiles of Streptococcus equi subsp. zooepidemicus Strains Isolated from Mares with Fertility Problems. Antibiotics (Basel) 2021 Dec 27;11(1).
    doi: 10.3390/antibiotics11010025pubmed: 35052902google scholar: lookup
  6. Ibrahim S, Hedia M, Taqi MO, Derbala MK, Mahmoud KGM, Ahmed Y, Sosa AS, Saber YHA, Hasanain MH, Nawito MF, Seidel GE. Extracellular vesicles in low volume uterine lavage and serum: novel and promising biomarker for endometritis in Arabian mares. BMC Vet Res 2022 Jan 18;18(1):42.
    doi: 10.1186/s12917-022-03137-3pubmed: 35042518google scholar: lookup
  7. Karam KM, Alebady AS, Alhilfi HO, Al-Delemi DH. Comparative study utilizing different post-breeding treatment regimens in cyclic Arabian mares. Vet World 2021 Nov;14(11):2863-2868.
    doi: 10.14202/vetworld.2021.2863-2868pubmed: 35017832google scholar: lookup
  8. Ibrahim S, Hedia M, Taqi MO, Derbala MK, Mahmoud KGM, Ahmed Y, Ismail S, El-Belely M. Alterations in the Expression Profile of Serum miR-155, miR-223, miR-17, miR-200a, miR-205, as well as Levels of Interleukin 6, and Prostaglandins during Endometritis in Arabian Mares. Vet Sci 2021 Jun 4;8(6).
    doi: 10.3390/vetsci8060098pubmed: 34199703google scholar: lookup
  9. Weber KS, Wagener K, Blanco M, Bauersachs S, Bollwein H. A comparative analysis of the intrauterine transcriptome in fertile and subfertile mares using cytobrush sampling. BMC Genomics 2021 May 22;22(1):377.
    doi: 10.1186/s12864-021-07701-3pubmed: 34022808google scholar: lookup
  10. Dawod A, Miro J, Elbaz HT, Fahmy H, Abdoon AS. Effect of Intrauterine Infusion of Equine Fresh Platelets-Rich Plasma (PRP) or Lyophilized PRP (L-GF(equina)) on Ovarian Activity and Pregnancy Rate in Repeat Breeder Purebred Arabian Mares. Animals (Basel) 2021 Apr 14;11(4).
    doi: 10.3390/ani11041123pubmed: 33919901google scholar: lookup
  11. Cequier A, Sanz C, Rodellar C, Barrachina L. The Usefulness of Mesenchymal Stem Cells beyond the Musculoskeletal System in Horses. Animals (Basel) 2021 Mar 25;11(4).
    doi: 10.3390/ani11040931pubmed: 33805967google scholar: lookup
  12. Köhne M, Kuhlmann M, Tönißen A, Martinsson G, Sieme H. Diagnostic and Treatment Practices of Equine Endometritis-A Questionnaire. Front Vet Sci 2020;7:547.
    doi: 10.3389/fvets.2020.00547pubmed: 32984410google scholar: lookup
  13. Lange-Consiglio A, Funghi F, Cantile C, Idda A, Cremonesi F, Riccaboni P. Case Report: Use of Amniotic Microvesicles for Regenerative Medicine Treatment of a Mare With Chronic Endometritis. Front Vet Sci 2020;7:347.
    doi: 10.3389/fvets.2020.00347pubmed: 32626730google scholar: lookup
  14. Canisso IF, Segabinazzi LGTM, Fedorka CE. Persistent Breeding-Induced Endometritis in Mares - a Multifaceted Challenge: From Clinical Aspects to Immunopathogenesis and Pathobiology. Int J Mol Sci 2020 Feb 20;21(4).
    doi: 10.3390/ijms21041432pubmed: 32093296google scholar: lookup
  15. Zhu H, Li W, Wang Z, Chen J, Ding M, Han L. TREM-1 deficiency attenuates the inflammatory responses in LPS-induced murine endometritis. Microb Biotechnol 2019 Nov;12(6):1337-1345.
    doi: 10.1111/1751-7915.13467pubmed: 31365951google scholar: lookup
  16. Mazzuchini MP, Canisso IF. The Apparent pH Stability of Antibiotic Preparations Used for Uterine Infusions in Mares. Animals (Basel) 2026 Jan 26;16(3).
    doi: 10.3390/ani16030382pubmed: 41681363google scholar: lookup
  17. Alfatlawy HJ. Microbial profile of post-breeding endometritis in Arabian mares from the Al-Hira District, Iraq. Open Vet J 2025;15(8):3670-3676.
    doi: 10.5455/OVJ.2025.v15.i8.30pubmed: 41035988google scholar: lookup
  18. Del Prete C, Attolini E, Merlo B, Iacono E, Nocera FP, De Martino L, Longobardi C, Damiano S, Longobardi V, Cocchia N, Pasolini MP. Post-Insemination Infusion of Wharton's Jelly Mesenchymal Stromal/Stem Cells-Derived Conditioned Medium: A Novel Approach for Improving Pregnancy Outcomes in Problem Mares. Vet Sci 2025 May 16;12(5).
    doi: 10.3390/vetsci12050482pubmed: 40431575google scholar: lookup
  19. Morawska-Kozłowska M, Pitas M, Zhalniarovich Y. Mesenchymal Stem Cells in Veterinary Medicine-Still Untapped Potential. Animals (Basel) 2025 Apr 19;15(8).
    doi: 10.3390/ani15081175pubmed: 40282009google scholar: lookup
  20. Yu J, Li X, Zhou M, Lu M, Ruan Z, Zou W, Yu S. Schisandrin B Inhibits LPS-Induced Endometritis Through Attenuating Ferroptosis via AMPK/PGC1α/Nrf2 Signalling Pathway. J Cell Mol Med 2024 Dec;28(23):e70281.
    doi: 10.1111/jcmm.70281pubmed: 39654025google scholar: lookup
  21. Wang Z, Zeng S, Wang Y, Wang T, Qu H, Zhu Y, Li J. Reproductive Disorders in Donkeys: Current Evidence and Update. Animals (Basel) 2024 Aug 28;14(17).
    doi: 10.3390/ani14172494pubmed: 39272279google scholar: lookup
  22. Scholtz M, Guthrie AJ, Newton R, Schulman ML. Review of Pseudomonas aeruginosa and Klebsiella pneumoniae as venereal pathogens in horses. Equine Vet J 2025 May;57(3):587-597.
    doi: 10.1111/evj.14201pubmed: 39103748google scholar: lookup
  23. Novello G, Souza FF, Canisso IF. Platelet-Rich Plasma Proteome of Mares Susceptible to Persistent-Breeding-Induced Endometritis Differs from Resistant Mares. Animals (Basel) 2024 Jul 18;14(14).
    doi: 10.3390/ani14142100pubmed: 39061562google scholar: lookup
  24. Silva JA, Castañares M, Mouguelar H, Valenciano JA, Pellegrino MS. Isolation of lactic acid bacteria from the reproductive tract of mares as potentially beneficial strains to prevent equine endometritis. Vet Res Commun 2024 Jun;48(3):1353-1366.
    doi: 10.1007/s11259-024-10295-2pubmed: 38233700google scholar: lookup
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