Endothelin 1 in healthy foals and in foals affected by neonatal diseases.
Abstract: In newborn babies, endothelin 1 (ET-1), a potent vasoconstrictor, increases during septicemia and severe respiratory syndromes. Because equine neonatal sepsis (ENS) and perinatal asphyxia syndrome (PAS) are major causes of morbidity and mortality in newborn foals and because no information on the concentration of ET-1 in healthy and sick foals has been reported yet, the aims of this study were (1) to define the serum concentration of Big ET-1 in healthy neonatal foals during the first week of age; (2) to preliminarily explore the diagnostic and prognostic role of Big ET-1 during ENS and PAS. Six healthy and 23 sick foals affected by ENS and/or PAS were enrolled in the study. In healthy foals, Big ET-1 concentration increased in the first hours of life until 24 hours after birth, and it remained constant during the first 3 days, then gradually decreased becoming significantly lower from Day 4 onward (P < 0.05). In sick foals, only 26.1% of animals showed higher values of Big ET-1 than controls at admission, and no difference between surviving and nonsurviving foals was found. Because in nonsurviving foals, Big ET-1 remained over the maximum value recorded in clinically healthy horses or, when normal at admission, increased over time; this study suggested that repeated measurement of Big ET-1 during hospitalization may be helpful in monitoring the course of the disease. In conclusion, possible prognostic information may be obtained by repeated analysis of Big ET-1 during hospitalization, but further studies are needed.
Copyright © 2015 Elsevier Inc. All rights reserved.
Publication Date: 2015-05-04 PubMed ID: 26007609DOI: 10.1016/j.theriogenology.2015.04.026Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research study investigates the concentration of Endothelin 1 (ET-1), a vasoconstrictor, in healthy foals and those affected by neonatal diseases such as equine neonatal sepsis (ENS) and perinatal asphyxia syndrome (PAS). The study suggests that repeated measurements of ET-1 during hospitalization may help monitor disease progression, although further studies are needed.
Research Goals
- The main objectives of the study were to examine and understand the serum concentration of Endothelin 1 (ET-1) in healthy foals during their first week of age.
- The researchers also wanted to investigate the diagnostic and prognostic role of ET-1 during occurrences of equine neonatal sepsis (ENS) and perinatal asphyxia syndrome (PAS).
Research Methodology
- The study subjects included six healthy foals and twenty-three sick foals affected by ENS and/or PAS.
- The researchers tracked and recorded the concentration of ET-1 over set time intervals to determine patterns and establish a standard range.
- Measurements were repeated during the hospitalization process, with a specific emphasis on the foals affected by ENS and PAS.
Research Findings
- In healthy foals, the concentration of ET-1 increased in the first 24 hours after birth, remained constant for the first three days, and then significantly decreased from the fourth day onwards.
- In sick foals affected by ENS and/or PAS, only 26.1% showed higher levels of ET-1 than the healthy control group upon admission.
- No significant difference was found in ET-1 levels between surviving and non-surviving foals.
- However, in non-surviving foals, ET-1 levels remained higher than those recorded in clinically healthy foals or increased over time if the levels were normal at admission.
Conclusion
- The research suggests that repeated measurement of ET-1 throughout hospitalization may aid in monitoring the progression of diseases in foals, specifically ENS and PAS.
- The team also hypothesizes that this process can offer prognostic information, although more research is needed to confirm these findings.
Cite This Article
APA
Giordano A, Castagnetti C, Panzani S, Paltrinieri S, Freccero F, Veronesi MC.
(2015).
Endothelin 1 in healthy foals and in foals affected by neonatal diseases.
Theriogenology, 84(5), 667-673.
https://doi.org/10.1016/j.theriogenology.2015.04.026 Publication
Researcher Affiliations
- Department of Veterinary Science and Public Health, University of Milan, Milan, Italy; Veterinary Teaching Hospital, Polo Veterinario di Lodi, University of Milan, Lodi, Italy.
- Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, Bologna, Italy.
- Department of Health, Animal Science and Food Safety, University of Milan, Milan, Italy. Electronic address: sara.panzani@unimi.it.
- Department of Veterinary Science and Public Health, University of Milan, Milan, Italy; Veterinary Teaching Hospital, Polo Veterinario di Lodi, University of Milan, Lodi, Italy.
- Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, Bologna, Italy.
- Department of Health, Animal Science and Food Safety, University of Milan, Milan, Italy.
MeSH Terms
- Animals
- Animals, Newborn / blood
- Biomarkers / blood
- Endothelin-1 / blood
- Female
- Horse Diseases / blood
- Horses / blood
- Male
- Predictive Value of Tests
- Prognosis
- Reference Values
Citations
This article has been cited 0 times.Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
