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Home / Equine Research Bank / Cytometry A / Equine cellular therapy–from stall to bench to bedside...
Cytometry. Part A : the journal of the International Society for Analytical Cytology2012; 83(1); 103-113; doi: 10.1002/cyto.a.22216

Equine cellular therapy–from stall to bench to bedside?

Abstract: Pioneering clinical stem cell research is being performed in the horse, a recipient of cutting edge veterinary medicine as well as a unique animal model, paving the way for human medical applications. Although demonstrable progress has been made on the clinical front, in vitro characterization of equine stem cells is still in comparatively early stages. To translate the promising results of clinical stem cell therapy in the horse, advances must be made in the characterization of equine stem cells. Aiming to improve communication between veterinarians and other natural scientists, this review gives an overview of veterinary "bedside" achievements, focusing on stem cell therapies in equine orthopedics as well as the current state of in vitro characterization of equine multipotent mesenchymal stromal cells (MSCs) and equine embryonic stem cells (ESCs).
Copyright © 2012 International Society for Advancement of Cytometry.
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Publication Date: 2012-10-18 PubMed ID: 23081833DOI: 10.1002/cyto.a.22216Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article presents cutting-edge clinical stem cell research in horses, which sets a foundation for implications in human medicine. Emphasis is on advancements in characterizing equine stem cells for translation to effective clinical therapy, with a specific focus on stem cell therapies for equine orthopedics and in-vitro development of equine multipotent mesenchymal stromal cells and equine embryonic stem cells.

Stem Cell Research in Horses

  • The research discusses developing pioneering clinical stem cell research in horses, known for receiving top-tier veterinary care.
  • The research’s underlying aim is to create developments which can be applied to human medical diagnoses and therapies.
  • Progress in clinical front is evident; however, the in-vitro characterization of equine stem cells is still in comparatively early stages.
  • The ultimate goal is to advance characterizations of equine stem cells so that promising clinical results can be translated into effective therapy.

Focus on Stem Cell Therapies in Equine Orthopedics

  • The article places specific emphasis on stem cell therapies in the field of equine orthopedics.
  • The purpose is to improve treatments for horses with orthopedic conditions and, by extension, potentially adapt and translate these therapies for use in human medicine.

In-vitro Development of Equine Stem Cells

  • The article also explores the state of in-vitro development of equine multipotent mesenchymal stromal cells (MSCs) and equine embryonic stem cells (ESCs).
  • These categories of stem cells hold significant potential for development and implementation of new cell-based therapies in veterinary medicine.
  • Progress and advancements made in the molecular and cellular understandings in horse biology can potentially be applied to improve stem cell treatments in human medicine.

Purpose and Communication

  • The paper also aims to improve communication between veterinarians and other natural scientists.
  • By presenting this cutting-edge research in a digestible manner, it seeks to facilitate conversation and encourage collaborations across different scientific fields.

Cite This Article

APA
Burk J, Badylak SF, Kelly J, Brehm W. (2012). Equine cellular therapy–from stall to bench to bedside? Cytometry A, 83(1), 103-113. https://doi.org/10.1002/cyto.a.22216

Publication

Cytometry. Part A : the journal of the International Society for Analytical Cytology
ISSN: 1552-4930
NlmUniqueID: 101235694
Country: United States
Language: English
Volume: 83
Issue: 1
Pages: 103-113

Researcher Affiliations

Burk, Janina
  • Faculty of Veterinary Medicine, Large Animal Clinic for Surgery, University of Leipzig, Leipzig, Germany.
Badylak, Stephen F
    Kelly, Jeremy
      Brehm, Walter

        MeSH Terms

        • Animals
        • Cell- and Tissue-Based Therapy / trends
        • Cell- and Tissue-Based Therapy / veterinary
        • Embryonic Stem Cells / cytology
        • Embryonic Stem Cells / transplantation
        • Horse Diseases / therapy
        • Horses
        • Immunophenotyping
        • In Vitro Techniques
        • Multipotent Stem Cells / cytology
        • Multipotent Stem Cells / transplantation
        • Orthopedics / methods
        • Orthopedics / veterinary
        • Veterinary Medicine / trends

        Citations

        This article has been cited 14 times.
        1. Phyo H, Aburza A, Mellanby K, Esteves CL. Characterization of canine adipose- and endometrium-derived Mesenchymal Stem/Stromal Cells and response to lipopolysaccharide.. Front Vet Sci 2023;10:1180760.
          doi: 10.3389/fvets.2023.1180760pubmed: 37275605google scholar: lookup
        2. Petrova V, Vachkova E. Outlook of Adipose-Derived Stem Cells: Challenges to Their Clinical Application in Horses.. Vet Sci 2023 May 12;10(5).
          doi: 10.3390/vetsci10050348pubmed: 37235430google scholar: lookup
        3. Meeremans M, Van de Walle GR, Van Vlierberghe S, De Schauwer C. The Lack of a Representative Tendinopathy Model Hampers Fundamental Mesenchymal Stem Cell Research.. Front Cell Dev Biol 2021;9:651164.
          doi: 10.3389/fcell.2021.651164pubmed: 34012963google scholar: lookup
        4. Chung MJ, Park S, Son JY, Lee JY, Yun HH, Lee EJ, Lee EM, Cho GJ, Lee S, Park HS, Jeong KS. Differentiation of equine induced pluripotent stem cells into mesenchymal lineage for therapeutic use.. Cell Cycle 2019 Nov;18(21):2954-2971.
          doi: 10.1080/15384101.2019.1664224pubmed: 31505996google scholar: lookup
        5. Shojaee A, Parham A. Strategies of tenogenic differentiation of equine stem cells for tendon repair: current status and challenges.. Stem Cell Res Ther 2019 Jun 18;10(1):181.
          doi: 10.1186/s13287-019-1291-0pubmed: 31215490google scholar: lookup
        6. Cortés-Araya Y, Amilon K, Rink BE, Black G, Lisowski Z, Donadeu FX, Esteves CL. Comparison of Antibacterial and Immunological Properties of Mesenchymal Stem/Stromal Cells from Equine Bone Marrow, Endometrium, and Adipose Tissue.. Stem Cells Dev 2018 Nov 1;27(21):1518-1525.
          doi: 10.1089/scd.2017.0241pubmed: 30044182google scholar: lookup
        7. Pöschke A, Krähling B, Failing K, Staszyk C. Molecular Characteristics of the Equine Periodontal Ligament.. Front Vet Sci 2017;4:235.
          doi: 10.3389/fvets.2017.00235pubmed: 29376061google scholar: lookup
        8. Schröck C, Eydt C, Geburek F, Kaiser L, Päbst F, Burk J, Pfarrer C, Staszyk C. Bone marrow-derived multipotent mesenchymal stromal cells from horses after euthanasia.. Vet Med Sci 2017 Nov;3(4):239-251.
          doi: 10.1002/vms3.74pubmed: 29152317google scholar: lookup
        9. Esteves CL, Sheldrake TA, Mesquita SP, Pesántez JJ, Menghini T, Dawson L, Péault B, Donadeu FX. Isolation and characterization of equine native MSC populations.. Stem Cell Res Ther 2017 Apr 18;8(1):80.
          doi: 10.1186/s13287-017-0525-2pubmed: 28420427google scholar: lookup
        10. Esteves CL, Sheldrake TA, Dawson L, Menghini T, Rink BE, Amilon K, Khan N, Péault B, Donadeu FX. Equine Mesenchymal Stromal Cells Retain a Pericyte-Like Phenotype.. Stem Cells Dev 2017 Jul 1;26(13):964-972.
          doi: 10.1089/scd.2017.0017pubmed: 28376684google scholar: lookup
        11. Arnhold S, Wenisch S. Adipose tissue derived mesenchymal stem cells for musculoskeletal repair in veterinary medicine.. Am J Stem Cells 2015;4(1):1-12.
          pubmed: 25973326
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          doi: 10.1002/jor.22848pubmed: 25664422google scholar: lookup
        13. Bellas E, Rollins A, Moreau JE, Lo T, Quinn KP, Fourligas N, Georgakoudi I, Leisk GG, Mazan M, Thane KE, Taeymans O, Hoffman AM, Kaplan DL, Kirker-Head CA. Equine model for soft-tissue regeneration.. J Biomed Mater Res B Appl Biomater 2015 Aug;103(6):1217-1227.
          doi: 10.1002/jbm.b.33299pubmed: 25350377google scholar: lookup
        14. Barberini DJ, Freitas NP, Magnoni MS, Maia L, Listoni AJ, Heckler MC, Sudano MJ, Golim MA, da Cruz Landim-Alvarenga F, Amorim RM. Equine mesenchymal stem cells from bone marrow, adipose tissue and umbilical cord: immunophenotypic characterization and differentiation potential.. Stem Cell Res Ther 2014 Feb 21;5(1):25.
          doi: 10.1186/scrt414pubmed: 24559797google scholar: lookup
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