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Home / Equine Research Bank / Vet Microbiol / Equine gammaherpesviruses: perfect parasites?
Veterinary microbiology2013; 167(1-2); 86-92; doi: 10.1016/j.vetmic.2013.05.031

Equine gammaherpesviruses: perfect parasites?

Abstract: The evolutionary success of the equine gammaherpesviruses (GHVs) is demonstrated by their consistent and widespread presence in horse populations worldwide. Equine GHVs establish infection in young foals and can be continually detected over the lifetime of the host either by recrudescence of latent infections or by re-infection. A definitive diagnosis of clinical disease in horses due to GHV infection remains challenging given the ubiquitous nature of the GHVs in horses without clinical signs, as well as in horses with clinical signs ranging from mild respiratory disease to severe equine multinodular pulmonary fibrosis. This review aims to examine what is known about equine GHV and explore the balance of the relationship that has evolved over millions of years between these viruses and their host.
Copyright © 2013 Elsevier B.V. All rights reserved.
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Publication Date: 2013-06-19 PubMed ID: 23845734DOI: 10.1016/j.vetmic.2013.05.031Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses the widespread presence of equine gammaherpesviruses (GHVs) in horse populations and the challenges associated with diagnosing clinical diseases caused by these infections due to their ubiquitous nature. The review also explores the evolution of the relationship between these viruses and their host.

The prevalence of Equine Gammaherpesviruses

  • The study begins by highlighting the evolutionary success of equine gammaherpesviruses (GHVs), underlining their consistent and widespread presence in horse populations worldwide. It suggests that these viruses are incredibly prevalent in horses and can maintain their presence throughout the lifetime of the host.
  • GHVs establish infection in young foals and can continue to be detected either through the reactivation of latent infections or through re-infection.

Diagnosing Clinical Diseases due to GHV infection

  • The article identifies the difficulties in definitively diagnosing clinical diseases in horses due to GHV infection. This challenge is attributed to the “ubiquitous” (or omnipresent) nature of GHVs, not just in horses with clinical signs, but also in those without.
  • Furthermore, the clinical signs observed in infected horses can range widely, from mild respiratory disease to severe conditions like equine multinodular pulmonary fibrosis, making it even more challenging to ascertain if GHV infection is the cause of the disease.

Evolution of the relationship between GHVs and their host

  • The study also aims to shed light on the balance of the relationship that has evolved over millions of years between equine GHVs and their hosts.
  • This implies a broader look at not only the impact of these viruses on the health of the horses but also how the relationship between the host and the virus has changed over time, possibly giving insights into disease progression, resistance, and treatment opportunities.

Cite This Article

APA
Hartley CA, Dynon KJ, Mekuria ZH, El-Hage CM, Holloway SA, Gilkerson JR. (2013). Equine gammaherpesviruses: perfect parasites? Vet Microbiol, 167(1-2), 86-92. https://doi.org/10.1016/j.vetmic.2013.05.031

Publication

Veterinary microbiology
ISSN: 1873-2542
NlmUniqueID: 7705469
Country: Netherlands
Language: English
Volume: 167
Issue: 1-2
Pages: 86-92
PII: S0378-1135(13)00316-7

Researcher Affiliations

Hartley, Carol A
  • Centre for Equine Infectious Disease, Department of Veterinary Science, The University of Melbourne, VIC 3010, Australia. Electronic address: carolah@unimelb.edu.au.
Dynon, Kemperly J
    Mekuria, Zelalem H
      El-Hage, Charles M
        Holloway, Steven A
          Gilkerson, James R

            MeSH Terms

            • Animals
            • Gammaherpesvirinae / classification
            • Gammaherpesvirinae / genetics
            • Gammaherpesvirinae / immunology
            • Gammaherpesvirinae / physiology
            • Herpesviridae Infections / diagnosis
            • Herpesviridae Infections / epidemiology
            • Herpesviridae Infections / veterinary
            • Herpesviridae Infections / virology
            • Horse Diseases / diagnosis
            • Horse Diseases / epidemiology
            • Horse Diseases / virology
            • Horses
            • Phylogeny

            Citations

            This article has been cited 20 times.
            1. Wondimagegnehu K, Leta S, Amenu K, Negussie H. Molecular detection and assessment of the epidemiological risk factors associated with equine herpesvirus 2 and 5 in working equids in central Ethiopia. Vet Med Sci 2022 Nov;8(6):2396-2403.
              doi: 10.1002/vms3.925pubmed: 36063540google scholar: lookup
            2. Onasanya AE, El-Hage C, Diaz-Méndez A, Vaz PK, Legione AR, Browning GF, Devlin JM, Hartley CA. Whole genome sequence analysis of equid gammaherpesvirus -2 field isolates reveals high levels of genomic diversity and recombination. BMC Genomics 2022 Aug 30;23(1):622.
              doi: 10.1186/s12864-022-08789-xpubmed: 36042397google scholar: lookup
            3. Stasiak K, Dunowska M, Rola J. Kinetics of the Equid Herpesvirus 2 and 5 Infections among Mares and Foals from Three Polish National Studs. Viruses 2022 Mar 29;14(4).
              doi: 10.3390/v14040713pubmed: 35458443google scholar: lookup
            4. El-Hage C, Mekuria Z, Dynon K, Hartley C, McBride K, Gilkerson J. Association of Equine Herpesvirus 5 with Mild Respiratory Disease in a Survey of EHV1, -2, -4 and -5 in 407 Australian Horses. Animals (Basel) 2021 Nov 30;11(12).
              doi: 10.3390/ani11123418pubmed: 34944194google scholar: lookup
            5. Altan E, Hui A, Li Y, Pesavento P, Asín J, Crossley B, Deng X, Uzal FA, Delwart E. New Parvoviruses and Picornavirus in Tissues and Feces of Foals with Interstitial Pneumonia. Viruses 2021 Aug 14;13(8).
              doi: 10.3390/v13081612pubmed: 34452477google scholar: lookup
            6. Mira F, Canuti M, Di Bella S, Puleio R, Lavazza A, Lelli D, Vicari D, Purpari G, Cannella V, Chiaramonte G, Schirò G, Castronovo C, Guercio A. Detection and Molecular Characterization of Two Gammaherpesviruses from Pantesco Breed Donkeys during an Outbreak of Mild Respiratory Disease. Viruses 2021 Aug 2;13(8).
              doi: 10.3390/v13081527pubmed: 34452391google scholar: lookup
            7. Stasiak K, Dunowska M, Trewick S, Rola J. Genetic Variation in the Glycoprotein B Sequence of Equid Herpesvirus 5 among Horses of Various Breeds at Polish National Studs. Pathogens 2021 Mar 9;10(3).
              doi: 10.3390/pathogens10030322pubmed: 33803246google scholar: lookup
            8. Jerele S, Davis E, Mapes S, Pusterla N, Navas González FJ, Iglesias Pastrana C, Abdelfattah EM, McLean A. Survey of Serum Amyloid A and Bacterial and Viral Frequency Using qPCR Levels in Recently Captured Feral Donkeys from Death Valley National Park (California). Animals (Basel) 2020 Jun 23;10(6).
              doi: 10.3390/ani10061086pubmed: 32585994google scholar: lookup
            9. Bond SL, Workentine M, Hundt J, Gilkerson JR, Léguillette R. Effects of nebulized dexamethasone on the respiratory microbiota and mycobiota and relative equine herpesvirus-1, 2, 4, 5 in an equine model of asthma. J Vet Intern Med 2020 Jan;34(1):307-321.
              doi: 10.1111/jvim.15671pubmed: 31793692google scholar: lookup
            10. Thorsteinsdóttir L, Jónsdóttir S, Stefánsdóttir SB, Andrésdóttir V, Wagner B, Marti E, Torsteinsdóttir S, Svansson V. The effect of maternal immunity on the equine gammaherpesvirus type 2 and 5 viral load and antibody response. PLoS One 2019;14(6):e0218576.
              doi: 10.1371/journal.pone.0218576pubmed: 31226153google scholar: lookup
            11. Dall Agnol AM, Beuttemmuller EA, Pilz D, Leme RA, Saporiti V, Headley SA, Alfieri AF, Alfieri AA. Detection of Equid gammaherpesvirus 2 and 5 DNA in the upper respiratory tract of asymptomatic horses from Southern Brazil. Braz J Microbiol 2019 Jul;50(3):875-878.
              doi: 10.1007/s42770-019-00100-7pubmed: 31187445google scholar: lookup
            12. Seeber PA, Dayaram A, Sicks F, Osterrieder N, Franz M, Greenwood AD. Noninvasive Detection of Equid Herpesviruses in Fecal Samples. Appl Environ Microbiol 2019 Feb 1;85(3).
              doi: 10.1128/AEM.02234-18pubmed: 30446563google scholar: lookup
            13. Marenzoni ML, Stefanetti V, Danzetta ML, Timoney PJ. Gammaherpesvirus infections in equids: a review. Vet Med (Auckl) 2015;6:91-101.
              doi: 10.2147/VMRR.S39473pubmed: 30155436google scholar: lookup
            14. Stasiak K, Dunowska M, Rola J. Prevalence and sequence analysis of equid herpesviruses from the respiratory tract of Polish horses. Virol J 2018 Jul 11;15(1):106.
              doi: 10.1186/s12985-018-1018-3pubmed: 29996858google scholar: lookup
            15. Couëtil LL, Cardwell JM, Gerber V, Lavoie JP, Léguillette R, Richard EA. Inflammatory Airway Disease of Horses--Revised Consensus Statement. J Vet Intern Med 2016 Mar-Apr;30(2):503-15.
              doi: 10.1111/jvim.13824pubmed: 26806374google scholar: lookup
            16. Lawler C, Milho R, May JS, Stevenson PG. Rhadinovirus host entry by co-operative infection. PLoS Pathog 2015 Mar;11(3):e1004761.
              doi: 10.1371/journal.ppat.1004761pubmed: 25790477google scholar: lookup
            17. Wilkie GS, Kerr K, Stewart JP, Studdert MJ, Davison AJ. Genome sequences of equid herpesviruses 2 and 5. Genome Announc 2015 Mar 12;3(2).
              doi: 10.1128/genomeA.00119-15pubmed: 25767243google scholar: lookup
            18. Marenzoni ML, Bietta A, Lepri E, Casagrande Proietti P, Cordioli P, Canelli E, Stefanetti V, Coletti M, Timoney PJ, Passamonti F. Role of equine herpesviruses as co-infecting agents in cases of abortion, placental disease and neonatal foal mortality. Vet Res Commun 2013 Dec;37(4):311-7.
              doi: 10.1007/s11259-013-9578-6pubmed: 24052369google scholar: lookup
            19. Stasiak K, Dunowska M, Rola J. Genetic Diversity of Equid Herpesvirus 5 in Temporal Samples from Mares and Their Foals at Three Polish National Studs. Int J Mol Sci 2025 Aug 27;26(17).
              doi: 10.3390/ijms26178298pubmed: 40943220google scholar: lookup
            20. James K, Chappell DE, Craig B, Pariseau C, Wright C, van Harreveld P, Barnum S, Pusterla N. Investigation of Selected Prevalence Factors Associated with EHV-2 and/or EHV-5 Infection in Horses with Acute Onset of Fever and Respiratory Signs. Viruses 2025 Apr 25;17(5).
              doi: 10.3390/v17050612pubmed: 40431624google scholar: lookup
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