Equine genomics: galloping to new frontiers.
Abstract: Analysis of the horse genome is proceeding at a rapid pace. Within a short span of 6-7 years, approximately 1,500 markers have been mapped in horse, of which at least half are genes/ESTs. Health, performance and phenotypic characteristic are of major concern/interest to horse breeders and owners. Current efforts to analyze the equine genome are primarily aimed at developing critical resources (including an advanced gene map) that could readily be used in the near future to i) identify genes and mutations responsible for inherited equine diseases/disorders and to formulate approaches for accurate diagnostics, therapeutics and prevention, ii) discover genes associated with various other traits of significance, e.g. fertility, disease resistance, coat color and athletic performance etc., and iii) use functional genomic approaches to identify gene regulatory events involved in the manifestation of various diseases.
Copyright 2003 S. Karger AG, Basel
Publication Date: 2004-02-19 PubMed ID: 14970700DOI: 10.1159/000075746Google Scholar: Lookup
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- Journal Article
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Summary
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This research article presents the progress and potential of horse genomics, particularly in mapping genes and markers related to health, performance and phenotypic traits, aiming to better understand and improve equine health and characteristics.
Studying the Horse Genome
In this study, the researchers delve into the world of horse genomics. Over a period of 6-7 years, around 1,500 markers have been mapped in the horse genome, half of which are genes or Expressed Sequence Tags (ESTs). These markers provide scientists with a roadmap of specific locations and genes that determine various characteristics in horses.
- These genetic markers are significant as they hint at the biological processes underlying health, performance, and physical attributes of horses.
- Advancements in genomics have allowed scientists to gain insights into the genetic makeup that embodies the different traits of horses, from health to athletic performance.
Goals of Equine Genomic Analysis
The focus of equine genomic analysis is directed towards developing resources, more specifically an advanced gene map, to identify genes and mutations causing inherited equine diseases and disorders.
- The eventual purpose of this research is to develop strategies for precise diagnostics, therapeutic interventions, and preventive measures for such conditions.
- Moreover, it aims to uncover genes linked with other significant traits such as fertility, disease resistance, coat color, and athletic performance, offering potential means to genetically enhance these traits.
- The study also aims to apply functional genomic approaches to identify gene regulatory events that play a role in the manifestation of various diseases. This information can help in the development of targeted treatments and preventive strategies.
Benefits and Applications
Understanding the horse genome and its various markers can have significant implications for horse breeders and owners.
- Uncovering the genetic basis of various traits can pave the way for precision breeding programs that aim to enhance desired qualities and minimize undesirable traits.
- It can help in the early detection of diseases, allowing for early intervention and preventing the manifestation of severe symptoms.
- Moreover, a comprehensive understanding of the horse genome could potentially unlock new paths in veterinary medicine and animal science, benefiting not only horses but other species as well.
Cite This Article
APA
Chowdhary BP, Bailey E.
(2004).
Equine genomics: galloping to new frontiers.
Cytogenet Genome Res, 102(1-4), 184-188.
https://doi.org/10.1159/000075746 Publication
Researcher Affiliations
- Department of Veterinary Anatomy & Public Health, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4458, USA. bchowdhary@cvm.tamu.edu
MeSH Terms
- Animals
- Genomics / trends
- Horses / genetics
Citations
This article has been cited 3 times.- Raudsepp T, Finno CJ, Bellone RR, Petersen JL. Ten years of the horse reference genome: insights into equine biology, domestication and population dynamics in the post-genome era.. Anim Genet 2019 Dec;50(6):569-597.
- Chowdhary BP, Raudsepp T. The horse genome derby: racing from map to whole genome sequence.. Chromosome Res 2008;16(1):109-27.
- Raudsepp T, Santani A, Wallner B, Kata SR, Ren C, Zhang HB, Womack JE, Skow LC, Chowdhary BP. A detailed physical map of the horse Y chromosome.. Proc Natl Acad Sci U S A 2004 Jun 22;101(25):9321-6.
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