The Journal of biological chemistry1974; 249(11); 3537-3542;

Equine hepatic and renal metallothioneins. Purification, molecular weight, amino acid composition, and metal content.

Abstract: No abstract available
Publication Date: 1974-06-10 PubMed ID: 4831228
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Cite This Article

APA
Ku00e4gi JH, Himmelhoch SR, Whanger PD, Bethune JL, Vallee BL. (1974). Equine hepatic and renal metallothioneins. Purification, molecular weight, amino acid composition, and metal content. J Biol Chem, 249(11), 3537-3542.

Publication

ISSN: 0021-9258
NlmUniqueID: 2985121R
Country: United States
Language: English
Volume: 249
Issue: 11
Pages: 3537-3542

Researcher Affiliations

Ku00e4gi, J H
    Himmelhoch, S R
      Whanger, P D
        Bethune, J L
          Vallee, B L

            MeSH Terms

            • Amino Acids / analysis
            • Animals
            • Cadmium / analysis
            • Chromatography, DEAE-Cellulose
            • Chromatography, Gel
            • Copper / analysis
            • Cysteine / analysis
            • Cysteine / metabolism
            • Electric Conductivity
            • Horses
            • Hydrogen-Ion Concentration
            • Kidney / analysis
            • Liver / analysis
            • Metalloproteins / analysis
            • Metalloproteins / isolation & purification
            • Metalloproteins / metabolism
            • Molecular Weight
            • Organ Specificity
            • Protein Binding
            • Spectrophotometry, Atomic
            • Sulfhydryl Compounds / analysis
            • Zinc / analysis

            Citations

            This article has been cited 56 times.
            1. Yuan AT, Stillman MJ. Arsenic binding to human metallothionein-3.. Chem Sci 2023 May 31;14(21):5756-5767.
              doi: 10.1039/d3sc00400gpubmed: 37265731google scholar: lookup
            2. Diaz D, Fonseca V, Aude YW, Lamas GA. Chelation therapy to prevent diabetes-associated cardiovascular events.. Curr Opin Endocrinol Diabetes Obes 2018 Aug;25(4):258-266.
              doi: 10.1097/MED.0000000000000419pubmed: 29846236google scholar: lookup
            3. Irvine GW, Stillman MJ. Residue Modification and Mass Spectrometry for the Investigation of Structural and Metalation Properties of Metallothionein and Cysteine-Rich Proteins.. Int J Mol Sci 2017 Apr 26;18(5).
              doi: 10.3390/ijms18050913pubmed: 28445428google scholar: lookup
            4. Deagen JT, Oh SH, Whanger PD. Biological function of metallothionein. VI. Metabolic interaction of cadmium and zinc in rats.. Biol Trace Elem Res 1980 Mar;2(1):65-80.
              doi: 10.1007/BF02789036pubmed: 24272854google scholar: lookup
            5. Petro A, Hill CH. Response of hepatic metallothionein to iron administration : Lack of correlation with serum corticosterone.. Biol Trace Elem Res 1987 Dec;14(3):255-63.
              doi: 10.1007/BF02795692pubmed: 24254827google scholar: lookup
            6. Lolkema PC, Donker MH, Schouten AJ, Ernst WH. The possible role of metallothioneins in copper tolerance of Silene cucubalus.. Planta 1984 Sep;162(2):174-9.
              doi: 10.1007/BF00410215pubmed: 24254053google scholar: lookup
            7. Freisinger E. Structural features specific to plant metallothioneins.. J Biol Inorg Chem 2011 Oct;16(7):1035-45.
              doi: 10.1007/s00775-011-0801-zpubmed: 21688177google scholar: lookup
            8. Reinecke F, Levanets O, Olivier Y, Louw R, Semete B, Grobler A, Hidalgo J, Smeitink J, Olckers A, Van der Westhuizen FH. Metallothionein isoform 2A expression is inducible and protects against ROS-mediated cell death in rotenone-treated HeLa cells.. Biochem J 2006 Apr 15;395(2):405-15.
              doi: 10.1042/BJ20051253pubmed: 16402917google scholar: lookup
            9. Jiang LJ, Maret W, Vallee BL. The ATP-metallothionein complex.. Proc Natl Acad Sci U S A 1998 Aug 4;95(16):9146-9.
              doi: 10.1073/pnas.95.16.9146pubmed: 9689048google scholar: lookup
            10. Claessens RA, Boerman OC, Koenders EB, Oyen WJ, van der Meer JW, Corstens FH. Technetium-99m labelled hydrazinonicotinamido human non-specific polyclonal immunoglobulin G for detection of infectious foci: a comparison with two other technetium-labelled immunoglobulin preparations.. Eur J Nucl Med 1996 Apr;23(4):414-21.
              doi: 10.1007/BF01247370pubmed: 8612662google scholar: lookup
            11. Fresno M, Wu W, Rodriguez JM, Nadji M. Localization of metallothionein in breast carcinomas. An immunohistochemical study.. Virchows Arch A Pathol Anat Histopathol 1993;423(3):215-9.
              doi: 10.1007/BF01614773pubmed: 8236816google scholar: lookup
            12. Hunziker PE, Kaur P, Wan M, Ku00e4nzig A. Primary structures of seven metallothioneins from rabbit tissue.. Biochem J 1995 Feb 15;306 ( Pt 1)(Pt 1):265-70.
              doi: 10.1042/bj3060265pubmed: 7864820google scholar: lookup
            13. Onishi T, Inubushi H, Tokugawa S, Muramatsu M, Nishikawa K, Suzuki Y, Miyao M. Abnormal copper metabolism in menkes cultured fibroblasts.. Eur J Pediatr 1980 Sep;134(3):205-10.
              doi: 10.1007/BF00441474pubmed: 7428771google scholar: lookup
            14. Parker RD, Sharma RP, Oberg SG. Distribution and accumulation of vanadium in mice tissues.. Arch Environ Contam Toxicol 1980;9(4):393-403.
              doi: 10.1007/BF01055291pubmed: 7406543google scholar: lookup
            15. Li TY, Minkel DT, Shaw CF 3rd, Petering DH. On the reactivity of metallothioneins with 5,5'-dithiobis-(2-nitrobenzoic acid).. Biochem J 1981 Feb 1;193(2):441-6.
              doi: 10.1042/bj1930441pubmed: 7305942google scholar: lookup
            16. Onishi T, Suzue J, Nishikawa K, Muramatsu M, Miyao M. Nature of copper and zinc compounds in tissues from a patient with Menkes kinky hair syndrome.. Eur J Pediatr 1981 Sep;137(1):17-21.
              doi: 10.1007/BF00441163pubmed: 7274294google scholar: lookup
            17. Anghileri LJ, Ottaviani M, Ricard S, Raynaud C. Radioruthenium -- 2,3-Dimercaptopropansulfonic acid complex. A potentially useful radiocompound for kidney studies.. Eur J Nucl Med 1981;6(9):403-5.
              doi: 10.1007/BF00266430pubmed: 7274291google scholar: lookup
            18. Minkel DT, Poulsen K, Wielgus S, Shaw CF 3rd, Petering DH. On the sensitivity of metallothioneins to oxidation during isolation.. Biochem J 1980 Nov 1;191(2):475-85.
              doi: 10.1042/bj1910475pubmed: 7236206google scholar: lookup
            19. Otvos JD, Armitage IM. Structure of the metal clusters in rabbit liver metallothionein.. Proc Natl Acad Sci U S A 1980 Dec;77(12):7094-8.
              doi: 10.1073/pnas.77.12.7094pubmed: 6938956google scholar: lookup
            20. Klauser S, Ku00e4gi JH, Wilson KJ. Characterization of isoprotein patterns in tissue extracts and isolated samples of metallothioneins by reverse-phase high-pressure liquid chromatography.. Biochem J 1983 Jan 1;209(1):71-80.
              doi: 10.1042/bj2090071pubmed: 6847618google scholar: lookup
            21. Li TY, Kraker AJ, Shaw CF 3rd, Petering DH. Ligand substitution reactions of metallothioneins with EDTA and apo-carbonic anhydrase.. Proc Natl Acad Sci U S A 1980 Nov;77(11):6334-8.
              doi: 10.1073/pnas.77.11.6334pubmed: 6779278google scholar: lookup
            22. Udom AO, Brady FO. Reactivation in vitro of zinc-requiring apo-enzymes by rat liver zinc-thionein.. Biochem J 1980 May 1;187(2):329-35.
              doi: 10.1042/bj1870329pubmed: 6772158google scholar: lookup
            23. Boulanger Y, Goodman CM, Forte CP, Fesik SW, Armitage IM. Model for mammalian metallothionein structure.. Proc Natl Acad Sci U S A 1983 Mar;80(6):1501-5.
              doi: 10.1073/pnas.80.6.1501pubmed: 6572910google scholar: lookup
            24. Litterst CL, Schweitzer VG. Increased tissue deposition and decreased excretion of platinum following administration of cisplatin to cisplatin-pretreated animals.. Cancer Chemother Pharmacol 1984;12(1):46-9.
              doi: 10.1007/BF00255909pubmed: 6537802google scholar: lookup
            25. Waalkes MP, Chernoff SB, Klaassen CD. Cadmium-binding proteins of rat testes. Characterization of a low-molecular-mass protein that lacks identity with metallothionein.. Biochem J 1984 Jun 15;220(3):811-8.
              doi: 10.1042/bj2200811pubmed: 6466305google scholar: lookup
            26. Templeton DM, Cherian MG. Chemical modifications of metallothionein. Preparation and characterization of polymers.. Biochem J 1984 Aug 1;221(3):569-75.
              doi: 10.1042/bj2210569pubmed: 6433886google scholar: lookup
            27. Cousins RJ. Metallothionein--aspects related to copper and zinc metabolism.. J Inherit Metab Dis 1983;6 Suppl 1:15-21.
              doi: 10.1007/BF01811318pubmed: 6413769google scholar: lookup
            28. Ku00e4gi JH, Vasu00e1k M, Lerch K, Gilg DE, Hunziker P, Bernhard WR, Good M. Structure of mammalian metallothionein.. Environ Health Perspect 1984 Mar;54:93-103.
              doi: 10.1289/ehp.54-1568188pubmed: 6329671google scholar: lookup
            29. Vasu00e1k M, Ku00e4gi JH. Metal thiolate clusters in cobalt(II)-metallothionein.. Proc Natl Acad Sci U S A 1981 Nov;78(11):6709-13.
              doi: 10.1073/pnas.78.11.6709pubmed: 6273885google scholar: lookup
            30. Garvey JS. Metallothionein: structure/antigenicity and detection/quantitation in normal physiological fluids.. Environ Health Perspect 1984 Mar;54:117-27.
              doi: 10.1289/ehp.8454117pubmed: 6203731google scholar: lookup
            31. Winge DR, Garvey JS. Antigenicity of metallothionein.. Proc Natl Acad Sci U S A 1983 May;80(9):2472-6.
              doi: 10.1073/pnas.80.9.2472pubmed: 6189123google scholar: lookup
            32. Holt D, Sparrow S, Webb M. The chronic toxicity of equine cadmium metallothionein in the rat.. Arch Toxicol 1985 Aug;57(3):200-4.
              doi: 10.1007/BF00290888pubmed: 4062555google scholar: lookup
            33. Dohi Y, Kosaka K, Ohba K, Yoneyama Y. Cadmium-binding proteins of three marine molluscs and characterization of two cadmium-binding glycoproteins from the hepatopancreas of a whelk, Buccinum tenuissimum.. Environ Health Perspect 1986 Mar;65:49-55.
              doi: 10.1289/ehp.866549pubmed: 3709465google scholar: lookup
            34. Frazier JM. Cadmium-binding proteins in the mussel, Mytilus edulis.. Environ Health Perspect 1986 Mar;65:39-43.
              doi: 10.1289/ehp.866539pubmed: 3709463google scholar: lookup
            35. Stone HC, Wilson SB, Overnell J. Cadmium-binding proteins in the scallop Pecten maximus.. Environ Health Perspect 1986 Mar;65:189-91.
              doi: 10.1289/ehp.8665189pubmed: 3709438google scholar: lookup
            36. Overnell J. Occurrence of cadmium in crabs (Cancer pagurus) and the isolation and properties of cadmium metallothionein.. Environ Health Perspect 1986 Mar;65:101-5.
              doi: 10.1289/ehp.8665101pubmed: 3709430google scholar: lookup
            37. Nartey N, Cherian MG, Banerjee D. Immunohistochemical localization of metallothionein in human thyroid tumors.. Am J Pathol 1987 Oct;129(1):177-82.
              pubmed: 3661677
            38. Reese RN, Wagner GJ. Properties of tobacco (Nicotiana tabacum) cadmium-binding peptide(s). Unique non-metallothionein cadmium ligands.. Biochem J 1987 Feb 1;241(3):641-7.
              doi: 10.1042/bj2410641pubmed: 3593213google scholar: lookup
            39. Kito H, Ose Y, Sato T. Cadmium-binding protein (metallothionein) in carp.. Environ Health Perspect 1986 Mar;65:117-24.
              doi: 10.1289/ehp.8665117pubmed: 3519201google scholar: lookup
            40. Vazquez F, Vasu00e1k M. Comparative 113Cd-n.m.r. studies on rabbit 113Cd7-, (Zn1,Cd6)- and partially metal-depleted 113Cd6-metallothionein-2a.. Biochem J 1988 Jul 15;253(2):611-4.
              doi: 10.1042/bj2530611pubmed: 3178730google scholar: lookup
            41. Paliwal VK, Kohli KK, Sharma M, Nath R. Purification and characterization of metallothionein from liver of cadmium exposed rhesus monkeys (Macaca mulatta).. Mol Cell Biochem 1986 Aug;71(2):139-47.
              doi: 10.1007/BF00214773pubmed: 3095629google scholar: lookup
            42. Dallinger R, Berger B, Bauer-Hilty A. Purification of cadmium-binding proteins from related species of terrestrial Helicidae (Gastropoda, Mollusca): a comparative study.. Mol Cell Biochem 1989 Feb 21;85(2):135-45.
              doi: 10.1007/BF00577109pubmed: 2725484google scholar: lookup
            43. Razak AA. Incorporation of cadmium into proteins in a cadmium tolerant fungi.. Biol Trace Elem Res 1989 Dec;22(3):277-85.
              doi: 10.1007/BF02916616pubmed: 2484413google scholar: lookup
            44. Kawaguchi S, Maita Y. Amino acid sequence of cadmium-binding peptide induced in a marine diatom, Phaeodactylum tricornutum.. Bull Environ Contam Toxicol 1990 Dec;45(6):893-9.
              doi: 10.1007/BF01701090pubmed: 1980625google scholar: lookup
            45. Chatterjee A, Maiti IB. Comparison of the immunological properties of mammalian (rodent), bird, fish, amphibian (toad), and invertebrate (crab) metallothioneins.. Mol Cell Biochem 1990 May 10;94(2):175-81.
              doi: 10.1007/BF00214124pubmed: 1695710google scholar: lookup
            46. Bremner I, Davies NT. The induction of metallothionein in rat liver by zinc injection and restriction of food intake.. Biochem J 1975 Sep;149(3):733-8.
              doi: 10.1042/bj1490733pubmed: 1201001google scholar: lookup
            47. Kojima Y, Berger C, Vallee BL, Ku00e4gi JH. Amino-acid sequence of equine renal metallothionein-1B.. Proc Natl Acad Sci U S A 1976 Oct;73(10):3413-7.
              doi: 10.1073/pnas.73.10.3413pubmed: 1068454google scholar: lookup
            48. Irons RD, Smith JC. Partial saturation of rat liver Cd-binding proteins by Cd2+ in vivo.. Arch Environ Contam Toxicol 1977;6(2-3):193-202.
              doi: 10.1007/BF02097760pubmed: 901001google scholar: lookup
            49. Hillyard SD, Gonick HC. Effects of Cd++ on short-circuit current across epithelial membranes. I. Interactions with Ca++ and vasopressin on frog skin.. J Membr Biol 1976 Mar 18;26(2-3):109-19.
              doi: 10.1007/BF01868869pubmed: 817028google scholar: lookup
            50. Hidalgo HA, Koppa V, Bryan SE. Induction of cadmium-thionein in isolated rat liver cells.. Biochem J 1978 Feb 15;170(2):219-225.
              doi: 10.1042/bj1700219pubmed: 637838google scholar: lookup
            51. Ohtake H, Koga M. Purification and characterization of zinc-binding protein from the liver of the partially hepatectomized rat.. Biochem J 1979 Dec 1;183(3):683-90.
              doi: 10.1042/bj1830683pubmed: 540039google scholar: lookup
            52. Meisler M, Orlowski C, Gross E, Bloor JH. Cadmium metabolism in cdm/cdm mice.. Biochem Genet 1979 Aug;17(7-8):731-6.
              doi: 10.1007/BF00502131pubmed: 540016google scholar: lookup
            53. Overnell J, Coombs TL. Purification and properties of plaice metallothionein, a cadmium-binding protein from the liver of the plaice (Pleuronectes platessa).. Biochem J 1979 Nov 1;183(2):277-83.
              doi: 10.1042/bj1830277pubmed: 534496google scholar: lookup
            54. Kumar R, Bawa SR. Hepatic silver binding protein (Ag BP) from sparrow (Passer domesticus).. Experientia 1979 Dec 15;35(12):1621-3.
              doi: 10.1007/BF01953229pubmed: 520476google scholar: lookup
            55. Bryan SE, Hidalgo HA, Koppa V, Smith HA. Cadmium, an effector in the synthesis of thionein.. Environ Health Perspect 1979 Feb;28:281-5.
              doi: 10.1289/ehp.7928281pubmed: 488043google scholar: lookup
            56. Yoshida A, Kaplan BE, Kimura M. Metal-binding and detoxification effect of synthetic oligopeptides containing three cysteinyl residues.. Proc Natl Acad Sci U S A 1979 Jan;76(1):486-90.
              doi: 10.1073/pnas.76.1.486pubmed: 284364google scholar: lookup