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The Veterinary clinics of North America. Equine practice2020; 36(1); 147-160; doi: 10.1016/j.cveq.2019.12.005

Equine Inflammatory Markers in the Twenty-First Century: A Focus on Serum Amyloid A.

Abstract: Serum amyloid A (SAA) is a marker of inflammation and infection in the horse that can be assessed in the field, with rapid and marked changes seen following initiation of an inflammatory stimulus. This quality of SAA also makes its clinical use challenging, because even small inflammatory conditions can cause large changes in SAA levels. Review of the current literature provides guidelines for responses of SAA to various conditions, which can be applied to specific clinical cases. The practitioner is encouraged to use SAA in conjunction with physical examination and other diagnostic modalities to guide treatment and monitor case progression.
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Publication Date: 2020-01-30 PubMed ID: 32007299PubMed Central: PMC7135104DOI: 10.1016/j.cveq.2019.12.005Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research focuses on Serum Amyloid A (SAA), a marker of inflammation and infection in horses, suggesting its use in conjunction with other diagnostic methods for guiding treatment, while noting its sensitivity to even minor inflammatory conditions.

Introduction to Serum Amyloid A (SAA)

  • SAA is an inflammatory marker found in horses. It is primarily used to identify and measure the level of inflammation and infection.
  • It can be evaluated in the field, thereby allowing for real-time monitoring of a horse’s health.
  • SAA levels change rapidly in response to an inflammatory stimulus. This characteristic supports prompt identification of infections or inflammation.

Using SAA in Clinical Practices

  • Despite its strengths, using SAA in a clinical setting can also be challenging. This is because even mild inflammatory conditions can cause significant alterations in SAA levels, making it harder to interpret results.
  • The article suggests that practitioners should use SAA in conjunction with regular physical examinations and other diagnostic tools.
  • This approach aids in developing an accurate assessment of the equine’s health status, devising an appropriate treatment plan, and tracking the progression of the condition.

Interpreting SAA Responses

  • Current scientific literature provides guidelines on how SAA responses can be interpreted based on various conditions.
  • These guidelines can be incorporated into clinical practice, helping vets tailor their diagnostics and treatment plans to specific cases.

Overall, the research points out the importance, benefits and challenges of using SAA as an inflammatory marker in horses, and encourages its use alongside other diagnostic modalities to guide treatment and monitor case progression.

Cite This Article

APA
Long A, Nolen-Walston R. (2020). Equine Inflammatory Markers in the Twenty-First Century: A Focus on Serum Amyloid A. Vet Clin North Am Equine Pract, 36(1), 147-160. https://doi.org/10.1016/j.cveq.2019.12.005

Publication

The Veterinary clinics of North America. Equine practice
ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 36
Issue: 1
Pages: 147-160
PII: S0749-0739(19)30074-4

Researcher Affiliations

Long, Alicia
  • Department of Clinical Studies, New Bolton Center, 382 West Street Road, Kennett Square, PA 19348, USA.
Nolen-Walston, Rose
  • Department of Clinical Studies, New Bolton Center, 382 West Street Road, Kennett Square, PA 19348, USA. Electronic address: rnolenw@upenn.edu.

MeSH Terms

  • Animals
  • Biomarkers / blood
  • Horse Diseases / blood
  • Horse Diseases / diagnosis
  • Horses
  • Inflammation / blood
  • Inflammation / veterinary
  • Serum Amyloid A Protein / metabolism

Conflict of Interest Statement

Disclosure The authors have nothing to disclose.

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