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Animal health research reviews2021; 22(1); 56-71; doi: 10.1017/S1466252321000050

Equine influenza: a comprehensive review from etiology to treatment.

Abstract: Influenza is an extremely contagious respiratory disease, which predominantly affects the upper respiratory tract. There are four types of influenza virus, and pigs and chickens are considered two key reservoirs of this virus. Equine influenza (EI) virus was first identified in horses in 1956, in Prague. The influenza A viruses responsible for EI are H7N7 and H3N8. Outbreaks of EI are characterized by their visible and rapid spread, and it has been possible to isolate and characterize H3N8 outbreaks in several countries. The clinical diagnosis of this disease is based on the clinical signs presented by the infected animals, which can be confirmed by performing complementary diagnostic tests. In the diagnosis of EI, in the field, rapid antigen detection tests can be used for a first approach. Treatment is based on the management of the disease and rest for the animal. Regarding the prognosis, it will depend on several factors, such as the animal's vaccination status. One of the important points in this disease is its prevention, which can be done through vaccination. In addition to decreasing the severity of clinical signs and morbidity during outbreaks, vaccination ensures immunity for the animals, reducing the economic impact of this disease.
Publication Date: 2021-06-02 PubMed ID: 34075870DOI: 10.1017/S1466252321000050Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't
  • Review

Summary

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The research article is a comprehensive review of equine influenza, a contagious respiratory disease primarily affecting horses, detailing everything from its origin to treatment strategies.

Understanding Equine Influenza

  • The study opens with a brief overview of influenza, a highly contagious respiratory disease known to mainly affect the upper respiratory tract. It highlights that there are four types of influenza virus, with pigs and chickens considered primary virus reservoirs.
  • Equine Influenza (EI), affecting horses, was first identified in 1956 in Prague. The common A types of influenza viruses triggering EI are specifically identified as H7N7 and H3N8.
  • EI outbreaks distinguish themselves by their rapid and evident spread. The H3N8 strain has been isolated and studied in various countries during such outbreaks.

Diagnosing Equine Influenza

  • The clinical diagnosis of EI is based on certain observable symptoms in the affected animals. These symptoms can be further confirmed through additional diagnostic tests.
  • For initial diagnosis in the field, rapid antigen detection tests are considered useful. These tests provide immediate results, enabling swift initial categorization of suspected cases.

Treatment and Management of Equine Influenza

  • Treatment strategies largely focus on disease management and ensuring adequate rest for the infected horse.
  • The prognosis or outcome of the condition is dependent on various factors, one of which is the animal’s vaccination status. It implicates the potential role of vaccination in managing the disease.

Prevention Strategies and Economic Impact

  • The study underlines prevention as one of the crucial aspects in managing the disease, mainly achievable through thorough vaccination.
  • Vaccination not only reduces the severity of clinical signs and morbidity but also secures immunity for the animals, thus lessening the economic repercussions associated with EI outbreaks.

Cite This Article

APA
Dionísio L, Medeiros F, Pequito M, Faustino-Rocha AI. (2021). Equine influenza: a comprehensive review from etiology to treatment. Anim Health Res Rev, 22(1), 56-71. https://doi.org/10.1017/S1466252321000050

Publication

ISSN: 1475-2654
NlmUniqueID: 101083072
Country: England
Language: English
Volume: 22
Issue: 1
Pages: 56-71

Researcher Affiliations

Dionísio, Luís
  • Faculty of Veterinary Medicine, Lusophone University of Humanities and Technologies, Lisbon, Portugal.
  • Military Academy, Lisbon, Portugal.
Medeiros, Francisco
  • Equine Military Veterinary Clinic, Army School of Arms, Mafra, Portugal.
Pequito, Manuel
  • Egas Moniz Higher Institute, Almada, Portugal.
Faustino-Rocha, Ana I
  • Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Vila Real, Portugal.
  • School of Sciences and Technology, University of Évora, Évora, Portugal.

MeSH Terms

  • Animals
  • Disease Outbreaks / prevention & control
  • Disease Outbreaks / veterinary
  • Horse Diseases / epidemiology
  • Horse Diseases / prevention & control
  • Horses
  • Humans
  • Influenza A Virus, H3N8 Subtype
  • Influenza A Virus, H7N7 Subtype
  • Influenza, Human
  • Orthomyxoviridae Infections / epidemiology
  • Orthomyxoviridae Infections / prevention & control
  • Orthomyxoviridae Infections / veterinary

Citations

This article has been cited 5 times.
  1. Gonzalez-Obando J, Forero JE, Zuluaga-Cabrera AM, Ruiz-Saenz J. Equine Influenza Virus: An Old Known Enemy in the Americas. Vaccines (Basel) 2022 Oct 14;10(10).
    doi: 10.3390/vaccines10101718pubmed: 36298583google scholar: lookup
  2. Sreenivasan CC, Uprety T, Reedy SE, Temeeyasen G, Hause BM, Wang D, Li F, Chambers TM. Experimental Infection of Horses with Influenza D Virus. Viruses 2022 Mar 23;14(4).
    doi: 10.3390/v14040661pubmed: 35458390google scholar: lookup
  3. Gonzalez-Obando J, Jaimes-Dueñez J, Zuluaga-Cabrera A, Forero JE, Diaz A, Rojas-Arbeláez C, Ruiz-Saenz J. Seroprevalence of Equine Influenza Virus Antibodies in Horses from Four Localities in Colombia. Viruses 2025 Jul 16;17(7).
    doi: 10.3390/v17070999pubmed: 40733615google scholar: lookup
  4. Pusterla N, Lawton K, Barnum S, Magdesian KG. Comparison of Nose Wipes, Stall Sponges, and Air Samples with Nasal Secretions for the Molecular Detection of Equine Influenza Virus in Clinically and Subclinically Infected Horses. Viruses 2025 Mar 20;17(3).
    doi: 10.3390/v17030449pubmed: 40143375google scholar: lookup
  5. Wasik BR, Rothschild E, Voorhees IEH, Reedy SE, Murcia PR, Pusterla N, Chambers TM, Goodman LB, Holmes EC, Kile JC, Parrish CR. Understanding the divergent evolution and epidemiology of H3N8 influenza viruses in dogs and horses. Virus Evol 2023;9(2):vead052.
    doi: 10.1093/ve/vead052pubmed: 37692894google scholar: lookup