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Home / Equine Research Bank / Front Vet Sci / Equine osteoarthritis: Strategies to enhance mesenchymal str...
Frontiers in veterinary science2023; 10; 1115774; doi: 10.3389/fvets.2023.1115774

Equine osteoarthritis: Strategies to enhance mesenchymal stromal cell-based acellular therapies.

Abstract: Osteoarthritis (OA) is a degenerative disease that eventually leads to the complete degradation of articular cartilage. Articular cartilage has limited intrinsic capacity for self-repair and, to date, there is no curative treatment for OA. Humans and horses have a similar articular cartilage and OA etiology. Thus, in the context of a One Health approach, progress in the treatment of equine OA can help improve horse health and can also constitute preclinical studies for human medicine. Furthermore, equine OA affects horse welfare and leads to significant financial losses in the equine industry. In the last few years, the immunomodulatory and cartilage regenerative potentials of mesenchymal stromal cells (MSCs) have been demonstrated, but have also raised several concerns. However, most of MSC therapeutic properties are contained in their secretome, particularly in their extracellular vesicles (EVs), a promising avenue for acellular therapy. From tissue origin to culture methods, various aspects must be taken into consideration to optimize MSC secretome potential for OA treatment. Immunomodulatory and regenerative properties of MSCs can also be enhanced by recreating a pro-inflammatory environment to mimic an pathological setting, but more unusual methods also deserve to be investigated. Altogether, these strategies hold substantial potential for the development of MSC secretome-based therapies suitable for OA management. The aim of this mini review is to survey the most recent advances on MSC secretome research with regard to equine OA.
Copyright © 2023 Jammes, Contentin, Cassé and Galéra.
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Publication Date: 2023-02-10 PubMed ID: 36846261PubMed Central: PMC9950114DOI: 10.3389/fvets.2023.1115774Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article presents a review of the latest advances in using mesenchymal stromal cells (MSCs) for outpatient treatment of osteoarthritis (OA) in horses, based on their secretome and the impact of different factors on its potential.

Introduction to Osteoarthritis in Equines

  • The article starts by outlining the significant challenge of Osteoarthritis (OA), a degenerative disease causing complete degradation of articular cartilage, in both humans and horses. The articular cartilage is limited in its inherent ability to self-repair and currently, has no definitive cure for OA.
  • The study highlights the similarity in articular cartilage and OA between humans and horses. The study on equine OA will not only improve horse health but also serve as an important preclinical study for human medicine.
  • The economic impact is also depicted, as equine OA leads to significant financial losses within the equine industry due to impacts on horse welfare.

Mesenchymal Stromal Cells and Their Potential

  • The focus then shifts to mesenchymal stromal cells (MSCs) and their potential for immunomodulation and cartilage regeneration. Their therapeutic properties are mainly contained within their secretome, specifically in their extracellular vesicles (EVs), which could potentially allow for the development of acellular therapy.
  • The paper points out the considerations that need to be made to optimize the potential of the MSC secretome for OA treatment. These include the tissue origin and culture methods used for the cells.

Enhancing the Therapeutic Properties of MSCs

  • The article also discusses how to enhance the therapeutic properties of MSCs. One approach is by recreating a pro-inflammatory environment, replicating the disease’s pathological setting. The authors suggest exploring unconventional methods as well.
  • The review concludes by emphasizing the potential of these strategies for developing MSC secretome-based therapies for OA management, given the substantial prospects they hold.

Aim of the Review

  • The goal of this mini review is to summarize the most recent advancements in MSC secretome research, specifically in the context of equine OA. By doing this, the researchers hope to shed light on the potential for new, effective treatment modes.

Cite This Article

APA
Jammes M, Contentin R, Cassé F, Galéra P. (2023). Equine osteoarthritis: Strategies to enhance mesenchymal stromal cell-based acellular therapies. Front Vet Sci, 10, 1115774. https://doi.org/10.3389/fvets.2023.1115774

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 10
Pages: 1115774
PII: 1115774

Researcher Affiliations

Jammes, Manon
  • BIOTARGEN, UNICAEN, Normandie University, Caen, France.
Contentin, Romain
  • BIOTARGEN, UNICAEN, Normandie University, Caen, France.
Cassé, Frédéric
  • BIOTARGEN, UNICAEN, Normandie University, Caen, France.
Galéra, Philippe
  • BIOTARGEN, UNICAEN, Normandie University, Caen, France.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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