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Equine recurrent uveitis: the viewpoint from the USA.
Abstract: Equine recurrent uveitis (ERU) is a common disease in horses in the USA. There have been many advances in the treatment of ERU; however, frequent misdiagnosis of ERU occurs in cases of primary corneal or uveal disease. It is critical to remember that primary uveitis (i.e. one bout of inflammation) is a different disease to ERU, which is an immune mediated recurrent uveitis. Standard symptomatic anti-inflammatory therapy is effective to control most cases of ERU; however, some horses require advanced therapy, such as placement of drug delivery devices or removal of the vitreous, when they fail to respond to the standard therapy.
Publication Date: 2010-10-14 PubMed ID: 20939168DOI: 10.1111/j.2042-3306.2010.tb05636.xGoogle Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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This paper focuses on equine recurrent uveitis (ERU), a common condition affecting horses in the USA. It discusses the advances in treatment, mentions the frequent misdiagnosis, and emphasises the importance of differentiating primary uveitis from ERU, as the latter is an immune-mediated recurrent inflammation.
Introduction to Equine Recurrent Uveitis (ERU)
- This research article discusses ERU, which is a prevalent disease among horses in the United States.
- ERU is an immune-mediated recurrent inflammation, meaning that the horse’s immune system is involved in causing repeated bouts of inflammation.
Misdiagnosis and Differentiation of ERU
- Issues of frequent misdiagnosis are addressed, highlighting the challenge in distinguishing ERU from primary corneal or uveal diseases.
- There is a critical difference between a primary uveitis (inflammation occurring once only) and ERU, which is recurrent.
- This differentiation is crucial to understand as it impacts the method and length of treatment provided for the horse.
Treatment of ERU
- The article emphasizes advances in ERU treatment procedures, demonstrating progress in addressing this common equine condition.
- For most cases, standard symptomatic anti-inflammatory therapy, which is aimed at reducing inflammation and alleviating symptoms, is effective in controlling ERU.
- However, in certain situations, if standard therapy does not yield positive results, more advanced treatments are necessitated.
- These advanced therapeutic methods may include the placement of drug delivery devices, which provide continuous medication delivery, or vitrectomy, a surgical procedure to remove some or all of the vitreous humor from the eye.
Cite This Article
APA
Gilger BC.
(2010).
Equine recurrent uveitis: the viewpoint from the USA.
Equine Vet J Suppl(37), 57-61.
https://doi.org/10.1111/j.2042-3306.2010.tb05636.x Publication
Researcher Affiliations
- North Carolina State University, Raleigh, North Carolina, USA.
MeSH Terms
- Animals
- Anti-Inflammatory Agents / therapeutic use
- Horse Diseases / epidemiology
- Horse Diseases / pathology
- Horse Diseases / therapy
- Horses
- Leptospirosis / complications
- Leptospirosis / veterinary
- Recurrence
- United States / epidemiology
- Uveitis / epidemiology
- Uveitis / pathology
- Uveitis / therapy
- Uveitis / veterinary
Citations
This article has been cited 17 times.- Kirmse L, Thieme K, Doherr MG, Eule JC. Evaluation of Laboratory Techniques for the Diagnosis of Leptospira-Associated Equine Recurrent Uveitis (ERU) With Focus on the Goldmann-Witmer Coefficient. Vet Ophthalmol 2026 Jan;29(1):e70132.
- Liu X, Peng Y, Zhang X, Wang X, Chen W, Kou X, Liang H, Ren W, Khan MZ, Wang C. Coloration in Equine: Overview of Candidate Genes Associated with Coat Color Phenotypes. Animals (Basel) 2024 Jun 17;14(12).
- Kalinovskiy A, Leser S, Ehrle A, Reese S, Jones S, Gerhards H. Phacoemulsification Combined with Pars Plana Vitrectomy: Outcome in Horses with Acquired Cataracts Associated with Uveitis. Animals (Basel) 2024 Apr 16;14(8).
- Scharre A, Scholler D, Gesell-May S, Müller T, Zablotski Y, Ertel W, May A. Comparison of veterinarians and a deep learning tool in the diagnosis of equine ophthalmic diseases. Equine Vet J 2025 Jan;57(1):47-53.
- Morén S, Kallberg M, Strom L. Equine uveitis: Outcome and adverse effects after one or two intravitreal low-dose gentamicin injections. Equine Vet J 2025 Jan;57(1):160-168.
- Cassano JM, Leonard BC, Martins BC, Vapniarsky N, Morgan JT, Dow SW, Wotman KL, Pezzanite LM. Preliminary evaluation of safety and migration of immune activated mesenchymal stromal cells administered by subconjunctival injection for equine recurrent uveitis. Front Vet Sci 2023;10:1293199.
- Plummer CE, Polk T, Sharma J, Bae SS, Barr O, Jones A, Kitchen H, Wilhelmy M, Devin K, Clay Smith W, Kolaczkowski BD, Larkin J 3rd. Open label safety and efficacy pilot to study mitigation of equine recurrent uveitis through topical suppressor of cytokine signaling-1 mimetic peptide. Sci Rep 2022 May 3;12(1):7177.
- Fingerhut L, Yücel L, Strutzberg-Minder K, von Köckritz-Blickwede M, Ohnesorge B, de Buhr N. Ex Vivo and In Vitro Analysis Identify a Detrimental Impact of Neutrophil Extracellular Traps on Eye Structures in Equine Recurrent Uveitis. Front Immunol 2022;13:830871.
- Wollanke B, Gerhards H, Ackermann K. Infectious Uveitis in Horses and New Insights in Its Leptospiral Biofilm-Related Pathogenesis. Microorganisms 2022 Feb 7;10(2).
- Ström L, Dalin F, Domberg M, Stenlund C, Bondesson U, Hedeland M, Toutain PL, Ekstrand C. Topical ophthalmic atropine in horses, pharmacokinetics and effect on intestinal motility. BMC Vet Res 2021 Apr 7;17(1):149.
- Flores MM, Del Piero F, Habecker PL, Langohr IM. A retrospective histologic study of 140 cases of clinically significant equine ocular disorders. J Vet Diagn Invest 2020 May;32(3):382-388.
- Fingerhut L, Ohnesorge B, von Borstel M, Schumski A, Strutzberg-Minder K, Mörgelin M, Deeg CA, Haagsman HP, Beineke A, von Köckritz-Blickwede M, de Buhr N. Neutrophil Extracellular Traps in the Pathogenesis of Equine Recurrent Uveitis (ERU). Cells 2019 Nov 27;8(12).
- Fischer BM, McMullen RJ Jr, Reese S, Brehm W. Intravitreal injection of low-dose gentamicin for the treatment of recurrent or persistent uveitis in horses: Preliminary results. BMC Vet Res 2019 Jan 16;15(1):29.
- Paschalis-Trela K, Cywińska A, Trela J, Czopowicz M, Kita J, Witkowski L. The prevalence of ocular diseases in polish Arabian horses. BMC Vet Res 2017 Nov 7;13(1):319.
- Sandmeyer LS, Bauer BS, Feng CX, Grahn BH. Equine recurrent uveitis in western Canadian prairie provinces: A retrospective study (2002-2015). Can Vet J 2017 Jul;58(7):717-722.
- Malalana F, Blundell RJ, Pinchbeck GL, Mcgowan CM. The role of Leptospira spp. in horses affected with recurrent uveitis in the UK. Equine Vet J 2017 Nov;49(6):706-709.
- Kulbrock M, Lehner S, Metzger J, Ohnesorge B, Distl O. A genome-wide association study identifies risk loci to equine recurrent uveitis in German warmblood horses. PLoS One 2013;8(8):e71619.
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