Evaluation of cambendazole paste against nematodes in horses in a field trial.
Abstract: The anthelmintic canbendazole (CBZ), adminis-
tered in several formulations to horses in critical
trials, has been shown to have high effcacy
against intestinal nematodes (3, 4, 6). There are
two reports of field trials with CBZ (2, 5), and
although a large number of horses were involved,
the efficacies reported were for a restricted
number of nematodes. Recently, CBZ paste was
administered to horses in another field trial and
the findings on rxdatability, safety and efficacy
against a wide range of nematodes are presented.
Publication Date: 1978-07-01 PubMed ID: 698899PubMed Central: PMC1789406
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- Journal Article
Summary
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The research tested the effectiveness of a paste form of the anthelmintic drug cambendazole (CBZ) in eliminating nematode infestations in horses, with positive results revealing its reliable efficacy, safety, and broad-spectrum application.
Method of the Study
- The study made use of the drug cambendazole (CBZ) which is usually administered in several formulations to horses. In this specific trial, it was administered in a paste form. CBZ has been exhibited to be highly efficient in the removal of intestinal nematodes in former critical trials.
Previous Efficacy Trials
- Previous field trials with CBZ have taken place, involving a large number of horses. However, in these earlier trials, the reported efficacies were limited and only applicable to a restricted number of varieties of nematodes.
Present Trial
- In this latest trial, CBZ paste was administered to horses in what is referred to as a field trial, meaning it was tested under normal, real-life conditions as opposed to a controlled lab setting.
- This trial aimed to verify the efficacy of the CBZ paste in combating a wide range of nematode varieties, rather than a restricted few as in previous trials.
Results of the Trial
- After the trial, the researchers found positive results regarding the reliability of the drug, its safety for use in horses, and effectiveness in eliminating a wide variety of nematode infestations.
Implications of the Research
- This research signifies key progress in anthelmintic field treatments as it demonstrates that CBZ paste can successfully be used to treat a wide range of nematode infestations in horses.
- The demonstrated safety and efficacy of the drug could lead to its broader use in equine healthcare, proving particularly useful in locations where deworming horses is challenging due to the wide variety of nematode species present.
Cite This Article
APA
Slocombe JO, Cote JF.
(1978).
Evaluation of cambendazole paste against nematodes in horses in a field trial.
Can Vet J, 19(7), 184-186.
Publication
Researcher Affiliations
MeSH Terms
- Animals
- Benzimidazoles / therapeutic use
- Cambendazole / therapeutic use
- Horse Diseases / drug therapy
- Horses
- Intestinal Diseases, Parasitic / drug therapy
- Intestinal Diseases, Parasitic / veterinary
- Nematode Infections / drug therapy
- Nematode Infections / veterinary
References
This article includes 8 references
- Slocombe JO, Smart J. Evaluation of pyrantel pamoate against strongyles in horses.. Can Vet J 1975 Oct;16(10):310-2.
- Ardans A, Walters G. Efficacy studies with three formulations of cambendazole in horses.. Am J Vet Res 1975 Nov;36(11):1589-90.
- Cook RW. Cambendazole paste as an anthelmintic in horses.. Vet Med Small Anim Clin 1975 Dec;70(12):1451-3.
- Bello TR, Amborski GF, Torbert BJ, Greer GJ. Anthelmintic efficacy of cambendazole against gastrointestinal parasites of the horse.. Am J Vet Res 1973 Jun;34(6):771-7.
- Drudge JH, Lyons ET, Tolliver SC. Critical tests of suspension, paste, and pellet formulations of cambendazole in the horse.. Am J Vet Res 1975 Apr;36(4 Pt.1):435-9.
- Amann RP, Bowen JM, Pickett BW, Berndtson WE, Stashak RS, Voss JL. Reproductive function in stallions treated with cambendazole.. J Am Vet Med Assoc 1977 Apr 1;170(7):730-2.
- Slocombe JO, Cote JF. Small strongyles of horses with cross resistance to benzimidazole anthelmintics and susceptibility to unrelated compounds.. Can Vet J 1977 Aug;18(8):212-7.
- Colglazier ML, Enzie FD, Kates KC. Critical anthelmintic trials in ponies with four benzimidazoles: mebendazole, cambendazole, fenbendazole, and albendazole.. J Parasitol 1977 Aug;63(4):724-7.
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