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Home / Equine Research Bank / Front Vet Sci / Evaluation of Colostral Immunity Against Equine Herpesvirus ...
Frontiers in veterinary science2020; 7; 579371; doi: 10.3389/fvets.2020.579371

Evaluation of Colostral Immunity Against Equine Herpesvirus Type 1 (EHV-1) in Martina Franca’s Foals.

Abstract: Eight Martina Franca pregnant jennies were selected in order to evaluate the transfer of colostral antibodies against equine herpesvirus type 1 in their relative foals after immunization with a commercial inactivated vaccine, compared with an unvaccinated group. Samples of serum and colostrums/milk were collected from jennies and foals under study starting from 10 min before and up to 21 days after the foaling. Specific anti-EHV-1 antibody titers were evaluated by means of a serum neutralization test, and the results obtained from both groups were analyzed. The serological titers in the vaccinated jennies was significantly higher ( 0.05). The antibody titers in milk at the time of delivery and subsequent withdrawal (T0 and T1) were very high in both groups, but no significant differences were found between the two groups ( > 0.05). In the foal sera, a significant difference was found between foals in the vaccinated group compared with those in the unvaccinated group ( < 0.05). Finally, a significant correlation ( < 0.05) was observed between the antibody titers found in serum and colostrum of jennies and the foal titers in the first time-point sampling (up to 12 h after foaling). The results confirm a substantial homology in the antibody production compared with other most investigated equids, highlighting the efficacy of the vaccination against EHV-1 of the jennies to ensure the protective immunity to their foals during the first weeks after delivery.
Copyright © 2020 Di Francesco, Smoglica, De Amicis, Cafini, Carluccio and Contri.
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Publication Date: 2020-11-23 PubMed ID: 33330699PubMed Central: PMC7732414DOI: 10.3389/fvets.2020.579371Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article investigates the efficacy of colostral antibodies against Equine Herpesvirus Type 1 (EHV-1) in foals of Martina Franca breed who were born to vaccinated mares, in comparison to an unvaccinated group.

Study Setup

  • The study involved eight pregnant Martina Franca jennies and their corresponding foals. The mares were vaccinated with a commercially available inactivated vaccine to protect them against EHV-1, while a control group remained unvaccinated.
  • Samples of colostrum, milk, and serum were collected from the mares and foals prior to and up to 21 days after birth, with specific antibody titers measured using a serum neutralization test.

Vaccination Impact

  • The vaccinated group showed significantly higher EHV-1 antibody titers in the mares’ serum compared to the unvaccinated group.
  • However, there were no significant differences at specific time intervals within both study groups, implying bloodstream concentration of the antibodies did not change dramatically over time.

Colostral Immunity

  • The antibody titers in the milk at the time of delivery and subsequently, showed a very high level in both vaccinated and unvaccinated groups. There was no significant difference between the two groups, meaning the vaccination did not influence the antibody levels in the colostrum or milk.
  • A significant difference was seen between foals of vaccinated mares and the unvaccinated group, with foals of vaccinated mares showing higher antibody titers.
  • Key findings revealed that there was a significant correlation between antibody levels in jennies’ sera and colostrum, and the resultant antibody titers in foals during the first 12 hours after birth.

Implications

  • The findings demonstrate that EHV-1 vaccination in Martina Franca jennies results in increased antibody titers in their foals, which provides the foals with protective immunity during their early weeks.
  • However, there’s no significant impact on colostrum or milk antibody levels, implying that protective immunity is primarily derived from the foal’s serum, rather than from the mother’s milk.
  • The results are important in guiding preventive interventions for EHV-1, showing that vaccination of mares can effectively boost immunity in newborn foals.

Cite This Article

APA
Di Francesco CE, Smoglica C, De Amicis I, Cafini F, Carluccio A, Contri A. (2020). Evaluation of Colostral Immunity Against Equine Herpesvirus Type 1 (EHV-1) in Martina Franca’s Foals. Front Vet Sci, 7, 579371. https://doi.org/10.3389/fvets.2020.579371

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 7
Pages: 579371
PII: 579371

Researcher Affiliations

Di Francesco, Cristina E
  • Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.
Smoglica, Camilla
  • Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.
De Amicis, Ippolito
  • Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.
Cafini, Federica
  • Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.
Carluccio, Augusto
  • Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.
Contri, Alberto
  • Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.

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Citations

This article has been cited 1 times.
  1. Warda FF, Ahmed HES, Shafik NG, Mikhael CA, Abd-ElAziz HMG, Mohammed WA, Shosha EA. Application of equine herpesvirus-1 vaccine inactivated by both formaldehyde and binary ethylenimine in equine. Vet World 2021 Jul;14(7):1815-1821.
    doi: 10.14202/vetworld.2021.1815-1821pubmed: 34475703google scholar: lookup
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