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Home / Equine Research Bank / Equine Vet J / Evaluation of histamine-provoked changes in airflow using el...
Equine veterinary journal2020; 52(4); 556-563; doi: 10.1111/evj.13216

Evaluation of histamine-provoked changes in airflow using electrical impedance tomography in horses.

Abstract: Electrical impedance tomography (EIT) generates thoracic impedance images of the lungs and has been used to assess ventilation in horses. This technique may have application in the detection of changes in airflow associated with equine asthma. Objective: The objective was to determine if histamine-induced airflow changes observed with flowmetric plethysmography (Δflow) could also be explained using global and regional respiratory gas flow signals calculated from EIT signals. Methods: Experimental in vivo study. Methods: Six horses, sedated using detomidine were fitted with a thoracic EIT belt and flowmetric plethysmography hardware. Saline (baseline = BL) and increasing concentrations of histamine (C1-4) were nebulised into the face mask until a change in breathing pattern was clinically confirmed and Δflow increased greater or equal to 50%. After nebulisation Δflow and EIT images were recorded over 3 minutes and peak global inspiratory (InF ) and expiratory (ExF ) flow as well as peak regional expiratory and inspiratory flow for the dorsal and the ventral area of the right and left lungs were evaluated. Delta flow, InF and ExF at subsequent concentrations were indexed to baseline (y  = C /BL-1). Indexed and nonindexed variables were evaluated for a difference from baseline at sequential histamine doses (time). Multiple linear regression assessment of variance in delta flow was also investigated. Results: Consistent with histamine-provoked increases in Δflow, the global flow indices increased significantly. A significant increase in regional inspiratory flow was seen in the right and left ventral lung and dorsal right lung. Multiple regression revealed that the variance in ExF , and right and left ventral expiratory flow best explained the variance in Δflow (r  = .82). Conclusions: Low number of horses and horses were healthy. Conclusions: Standardised changes in airflow during histamine challenge could be detected using EIT gas flow variables.
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Publication Date: 2020-02-12 PubMed ID: 31793056DOI: 10.1111/evj.13216Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper focuses on assessing whether Electrical Impedance Tomography (EIT), a technique used to create images of the lungs, can also be used to track changes in airflow in horses caused by histamine. The study indicates these EIT-derived measures might be reliable indicators of changes in airflow due to histamine reaction, a part of equine asthma diagnosis.

Objective and Methodology

The objective of this study was to find out whether EIT-generated respiratory signals could explain airflow changes in horses subjected to a histamine-incident. That is usually checked with flowmetric plethysmography (Δflow).

  • Six horses were sedated and fitted with a thoracic EIT belt and flowmetric plethysmography equipment.
  • A baseline was achieved using saline, and then increasingly higher concentrations of histamine were nebulised into the face mask of these horses.
  • The change in the breathing pattern and increased Δflow of over or equal to 50% confirmed the histamine effect.
  • Δflow and EIT images were recorded over three minutes after each nebulisation.
  • Peak global inspiratory (InF) and expiratory (ExF) flow, along with peak regional expiratory and inspiratory flow for the right and left lungs’ ventral and dorsal areas, were assessed.

In this study, all the indexed and nonindexed variables from each histamine dose were evaluated sequentially compared to the baseline. The deviation in delta flow was also examined using multiple linear regression.

Results

The results from this study reflected that the global flow indices had a significant increase, therefore reflecting the histamine-induced increase in Δflow. Also, a significant increase in regional inspiratory flow was observed in the right and left ventral lung and the dorsal right lung. The Δflow variance was best explained by variance in ExF, and right and left ventral expiratory flow as was detected by multiple regression. Thus, indicating that the prominent changes in airflow provoked by histamine can be traced using EIT gas flow variables.

Conclusions

Despite the low number of participants and their healthy state, the study concludes that standardised changes in airflow during a histamine challenge are detectable using EIT gas flow variables. This could potentially point to wider applications of EIT in equine healthcare, such as diagnosing and assessing equine asthma.

Cite This Article

APA
Secombe C, Waldmann AD, Hosgood G, Mosing M. (2020). Evaluation of histamine-provoked changes in airflow using electrical impedance tomography in horses. Equine Vet J, 52(4), 556-563. https://doi.org/10.1111/evj.13216

Publication

Equine veterinary journal
ISSN: 2042-3306
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 52
Issue: 4
Pages: 556-563

Researcher Affiliations

Secombe, Cristy
  • School of Veterinary Medicine, College of Science, Health, Engineering and Education, Murdoch University, Perth, Australia.
Waldmann, Andreas D
  • Department of Anesthesiology and Intensive Care Medicine, Rostock University Medical Center, Rostock, Germany.
Hosgood, Giselle
  • School of Veterinary Medicine, College of Science, Health, Engineering and Education, Murdoch University, Perth, Australia.
Mosing, Martina
  • School of Veterinary Medicine, College of Science, Health, Engineering and Education, Murdoch University, Perth, Australia.

MeSH Terms

  • Animals
  • Electric Impedance
  • Histamine
  • Horses
  • Lung
  • Plethysmography
  • Respiration

References

This article includes 31 references
  1. Couetil LL, Cardwell JM, Gerber V, Lavoie JP, Leguillette R, Richard EA. Inflammatory airway disease of horses-revised consensus statement.. J Vet Intern Med 2016;30:503-15.
  2. Hoffman A, Kuehn H, Riedelberger K, Kupcinskas R, Miskovic MB. Flowmetric comparison of respiratory inductance plethysmography and pneumotachography in horses.. J Appl Physiol (1985) 2001;91:2767-75.
  3. Hoffman A. Clinical application of pulmonary function testing in horses.. In: Lekeux P, editor. Equine respiratory diseases. Ithaca, USA: International Veterinary Information Service, 2002; p. 1-29.
  4. Ambrisko TD, Schramel JP, Adler A, Kutasi O, Makra Z, Moens YP. Assessment of distribution of ventilation by electrical impedance tomography in standing horses.. Physiol Meas 2016;37:175-86.
  5. Mosing M, Auer U, MacFarlane P, Bardell D, Schramel JP, Bohm SH. Regional ventilation distribution and dead space in anaesthetized horses treated with and without continuous positive airway pressure: novel insights by electrical impedance tomography and volumetric capnography.. Vet Anaesth Analg 2018;45:31-40.
  6. Mosing M, Waldmann AD, MacFarlane P, Iff S, Auer U, Bohm SH. Horses auto-recruit their lungs by inspiratory breath holding following recovery from general anaesthesia.. PLoS ONE 2016;11:e0158080.
  7. Costa EL, Chaves CN, Gomes S, Beraldo MA, Volpe MS, Tucci MR. Real-time detection of pneumothorax using electrical impedance tomography.. Crit Care Med 2008;36:1230-8.
  8. Mosing M, Waldmann AD, Raisis A, Bohm SH, Drynan E, Wilson K. Monitoring of tidal ventilation by electrical impedance tomography in anaesthetised horses.. Equine Vet J 2019;51:222-6.
  9. Bodenstein M, Boehme S, Bierschock S, Vogt A, David M, Markstaller K. Determination of respiratory gas flow by electrical impedance tomography in an animal model of mechanical ventilation.. BMC Pulm Med 2014;14:73.
  10. Waldmann AD, Böhm S, Mosing M, Tusman G. Distribution of regional peak expiratory flow under different body positions and ventilation conditions determined by electrical impedance tomography (EIT).. In: 15. Kongress der Deutschen interdisziplinären Vereinigung für Intensiv- und Notfallmedizin. Leipzig, Germany: Deutsche interdisziplinären Vereinigung für Intensiv- und Notfallmedizin, 2015.
  11. Ngo C, Dippel F, Tenbrock K, Leonhardt S, Lehmann S. Flow-volume loops measured with electrical impedance tomography in pediatric patients with asthma.. Pediatr Pulmonol 2018;53:636-44.
  12. Henneke DR, Potter GD, Kreider JL, Yeates BF. Relationship between conditon score, physical measurements and body fat percentage in mares.. Equine Vet J 1983;15:371-2.
  13. Adler A, Arnold JH, Bayford R, Borsic A, Brown B, Dixon P. GREIT: a unified approach to 2D linear EIT reconstruction of lung images.. Physiol Meas 2009;30:S35-55.
  14. Frerichs I, Amato MB, van Kaam AH, Tingay DG, Zhao Z, Grychtol B, TREND Study Group. Chest electrical impedance tomography examination, data analysis, terminology, clinical use and recommendations: consensus statement of the TRanslational EIT developmeNt stuDy group (TREND).. Thorax 2017;72:83-93.
  15. Karagiannidis C, Waldmann AD, Roka PL, Schreiber T, Strassmann S, Windisch W. Regional expiratory time constants in severe respiratory failure estimated by electrical impedance tomography: a feasibility study.. Crit Care 2018;22:221.
  16. Hoffman A. Clincial application of pulmonary function testing in horses.. In: Lekeux P, editor. Equine Respiratory Disease. Ithaca, USA: International Veterinary Information Service, 2002; p. 1-29.
  17. Nyman G, Marntell S, Edner A, Funkquist P, Morgan K, Hedenstierna G. Effect of sedation with detomidine and butorphanol on pulmonary gas exchange in the horse.. Acta Vet Scand 2009;51:22.
  18. Ambulatory Monitoring Inc. The Open Pleth™ System manual: version 3.3.. New York, 2010.
  19. Róka PL, Waldmann AD, Böhm SH, Karagiannidis C, Ender F. Software Tool for Analysing Ventilation EIT Data.. In: 16th International Conference on Biomedical Applications of Electrical Impedance Tomography, 2016.
  20. Mosing M, Marly-Voquer C, MacFarlane P, Bardell D, Bohm SH, Bettschart-Wolfensberger R. Regional distribution of ventilation in horses in dorsal recumbency during spontaneous and mechanical ventilation assessed by electrical impedance tomography: a case series.. Vet Anaesth Analg 2017;44:127-32.
  21. Ambrisko TD, Schramel J, Hopster K, Kastner S, Moens Y. Assessment of distribution of ventilation and regional lung compliance by electrical impedance tomgraphy in anaesthetized horses undergoing alveolar recruitment manoeuvres.. Vet Anaesth Analg 2017;44:264-72.
  22. Hoffman AM, Oura TH, Riedelberger KJ, Mazan MR. Plethysmographic comparison of breathing pattern in heaves (recurrent airway obstruction) versus experimental bronchoconstriction or hyperpnea in horses.. J Vet Intern Med 2007;21:184-92.
  23. Petsche VM, Derksen FJ, Robinson NE. Tidal breathing flow-volume loops in horses with recurrent airway obstruction (heaves).. Am J Vet Res 1994;55:885-91.
  24. Herholz C, Straub R, Braendlin C, Imhof A, Luthi S, Busato A. Measurement of tidal breathing flow-volume loop indices in horses used for different sporting purposes with and without recurrent airway obstruction.. Vet Rec 2003;152:288-92.
  25. Guthrie AJ, Beadle RE, Bateman RD, White CE. The effects of three models of airway disease on tidal breathing flow-volume loops of thoroughbred horses.. Vet Res Commun 1995;19:517-27.
  26. Asgharian B, Price OT, Hofmann W. Prediction of particle deposition in the human lung using realistic models of lung ventilation.. J Aerosol Sci 2006;37:1209-21.
  27. Aggarwal B, Mulgirigama A, Berend N. Exercise-induced bronchoconstriction: prevalence, pathophysiology, patient impact, diagnosis and management.. NPJ Prim Care Respir Med 2018;28:31.
  28. Boulet LP, O'Byrne PM. Asthma and exercise-induced bronchoconstriction in athletes.. N Engl J Med 2015;372:641-8.
  29. England GC, Clarke KW, Goossens L. A comparison of the sedative effects of three alpha 2-adrenoceptor agonists (romifidine, detomidine and xylazine) in the horse.. J Vet Pharmacol Ther 1992;15:194-201.
  30. Williams DC, Aleman M, Tharp B, Fletcher DJ, Kass PH, Steffey EP. Qualitative and quantitative characteristics of the electroencephalogram in normal horses after sedation.. J Vet Intern Med 2012;26:645-53.
  31. Gozalo-Marcilla M, De Oliveira AR, Fonseca MW, Possebon FS, Pelligand L, Taylor PM. Sedative and antinociceptive effects of different detomidine constant rate infusions, with or without methadone in standing horses.. Equine Vet J 2019;51:530-6.

Citations

This article has been cited 6 times.
  1. Brabant OA, Byrne DP, Sacks M, Moreno Martinez F, Raisis AL, Araos JB, Waldmann AD, Schramel JP, Ambrosio A, Hosgood G, Braun C, Auer U, Bleul U, Herteman N, Secombe CJ, Schoster A, Soares J, Beazley S, Meira C, Adler A, Mosing M. Thoracic Electrical Impedance Tomography-The 2022 Veterinary Consensus Statement.. Front Vet Sci 2022;9:946911.
    doi: 10.3389/fvets.2022.946911pubmed: 35937293google scholar: lookup
  2. Kozłowska N, Wierzbicka M, Jasiński T, Domino M. Advances in the Diagnosis of Equine Respiratory Diseases: A Review of Novel Imaging and Functional Techniques.. Animals (Basel) 2022 Feb 4;12(3).
    doi: 10.3390/ani12030381pubmed: 35158704google scholar: lookup
  3. Herteman N, Mosing M, Waldmann AD, Gerber V, Schoster A. Exercise-induced airflow changes in horses with asthma measured by electrical impedance tomography.. J Vet Intern Med 2021 Sep;35(5):2500-2510.
    doi: 10.1111/jvim.16260pubmed: 34505734google scholar: lookup
  4. Sacks M, Byrne DP, Herteman N, Secombe C, Adler A, Hosgood G, Raisis AL, Mosing M. Electrical impedance tomography to measure lung ventilation distribution in healthy horses and horses with left-sided cardiac volume overload.. J Vet Intern Med 2021 Sep;35(5):2511-2523.
    doi: 10.1111/jvim.16227pubmed: 34347908google scholar: lookup
  5. Secombe C, Adler A, Hosgood G, Raisis A, Mosing M. Can bronchoconstriction and bronchodilatation in horses be detected using electrical impedance tomography?. J Vet Intern Med 2021 Jul;35(4):2035-2044.
    doi: 10.1111/jvim.16152pubmed: 33977584google scholar: lookup
  6. Sang L, Zhao Z, Lin Z, Liu X, Zhong N, Li Y. A narrative review of electrical impedance tomography in lung diseases with flow limitation and hyperinflation: methodologies and applications.. Ann Transl Med 2020 Dec;8(24):1688.
    doi: 10.21037/atm-20-4984pubmed: 33490200google scholar: lookup
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