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Equine veterinary journal2020; 52(4); 556-563; doi: 10.1111/evj.13216

Evaluation of histamine-provoked changes in airflow using electrical impedance tomography in horses.

Abstract: Electrical impedance tomography (EIT) generates thoracic impedance images of the lungs and has been used to assess ventilation in horses. This technique may have application in the detection of changes in airflow associated with equine asthma. Objective: The objective was to determine if histamine-induced airflow changes observed with flowmetric plethysmography (Δflow) could also be explained using global and regional respiratory gas flow signals calculated from EIT signals. Methods: Experimental in vivo study. Methods: Six horses, sedated using detomidine were fitted with a thoracic EIT belt and flowmetric plethysmography hardware. Saline (baseline = BL) and increasing concentrations of histamine (C1-4) were nebulised into the face mask until a change in breathing pattern was clinically confirmed and Δflow increased greater or equal to 50%. After nebulisation Δflow and EIT images were recorded over 3 minutes and peak global inspiratory (InF ) and expiratory (ExF ) flow as well as peak regional expiratory and inspiratory flow for the dorsal and the ventral area of the right and left lungs were evaluated. Delta flow, InF and ExF at subsequent concentrations were indexed to baseline (y  = C /BL-1). Indexed and nonindexed variables were evaluated for a difference from baseline at sequential histamine doses (time). Multiple linear regression assessment of variance in delta flow was also investigated. Results: Consistent with histamine-provoked increases in Δflow, the global flow indices increased significantly. A significant increase in regional inspiratory flow was seen in the right and left ventral lung and dorsal right lung. Multiple regression revealed that the variance in ExF , and right and left ventral expiratory flow best explained the variance in Δflow (r  = .82). Conclusions: Low number of horses and horses were healthy. Conclusions: Standardised changes in airflow during histamine challenge could be detected using EIT gas flow variables.
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Publication Date: 2020-02-12 PubMed ID: 31793056DOI: 10.1111/evj.13216Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper focuses on assessing whether Electrical Impedance Tomography (EIT), a technique used to create images of the lungs, can also be used to track changes in airflow in horses caused by histamine. The study indicates these EIT-derived measures might be reliable indicators of changes in airflow due to histamine reaction, a part of equine asthma diagnosis.

Objective and Methodology

The objective of this study was to find out whether EIT-generated respiratory signals could explain airflow changes in horses subjected to a histamine-incident. That is usually checked with flowmetric plethysmography (Δflow).

  • Six horses were sedated and fitted with a thoracic EIT belt and flowmetric plethysmography equipment.
  • A baseline was achieved using saline, and then increasingly higher concentrations of histamine were nebulised into the face mask of these horses.
  • The change in the breathing pattern and increased Δflow of over or equal to 50% confirmed the histamine effect.
  • Δflow and EIT images were recorded over three minutes after each nebulisation.
  • Peak global inspiratory (InF) and expiratory (ExF) flow, along with peak regional expiratory and inspiratory flow for the right and left lungs’ ventral and dorsal areas, were assessed.

In this study, all the indexed and nonindexed variables from each histamine dose were evaluated sequentially compared to the baseline. The deviation in delta flow was also examined using multiple linear regression.

Results

The results from this study reflected that the global flow indices had a significant increase, therefore reflecting the histamine-induced increase in Δflow. Also, a significant increase in regional inspiratory flow was observed in the right and left ventral lung and the dorsal right lung. The Δflow variance was best explained by variance in ExF, and right and left ventral expiratory flow as was detected by multiple regression. Thus, indicating that the prominent changes in airflow provoked by histamine can be traced using EIT gas flow variables.

Conclusions

Despite the low number of participants and their healthy state, the study concludes that standardised changes in airflow during a histamine challenge are detectable using EIT gas flow variables. This could potentially point to wider applications of EIT in equine healthcare, such as diagnosing and assessing equine asthma.

Cite This Article

APA
Secombe C, Waldmann AD, Hosgood G, Mosing M. (2020). Evaluation of histamine-provoked changes in airflow using electrical impedance tomography in horses. Equine Vet J, 52(4), 556-563. https://doi.org/10.1111/evj.13216

Publication

Equine veterinary journal
ISSN: 2042-3306
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 52
Issue: 4
Pages: 556-563

Researcher Affiliations

Secombe, Cristy
  • School of Veterinary Medicine, College of Science, Health, Engineering and Education, Murdoch University, Perth, Australia.
Waldmann, Andreas D
  • Department of Anesthesiology and Intensive Care Medicine, Rostock University Medical Center, Rostock, Germany.
Hosgood, Giselle
  • School of Veterinary Medicine, College of Science, Health, Engineering and Education, Murdoch University, Perth, Australia.
Mosing, Martina
  • School of Veterinary Medicine, College of Science, Health, Engineering and Education, Murdoch University, Perth, Australia.

MeSH Terms

  • Animals
  • Electric Impedance
  • Histamine
  • Horses
  • Lung
  • Plethysmography
  • Respiration

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Citations

This article has been cited 7 times.
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