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Veterinary research communications1995; 19(6); 517-527; doi: 10.1007/BF01839340

The effects of three models of airway disease on tidal breathing flow-volume loops of thoroughbred horses.

Abstract: The effects of histamine and methacholine aerosols and of a fixed inspiratory resistance on tidal breathing flow-volume loops (TBFVL) were investigated using 18 unsedated, standing, healthy thoroughbred horses. The data were first analysed using traditional flow-volume loop indices and then reduced using standardized factor scoring coefficients obtained in a previous study in this laboratory using similar experimental techniques. On the basis of resting TBFVL analysis, the degree of pulmonary dysfunction caused by inhalation of histamine and methacholine aerosols with concentrations of 10 and 2 mg/ml, respectively, was similar. The fixed resistance also caused significant changes in the resting spirogram and TBFVL indices, suggesting that this model may prove valuable for further studies involving upper respiratory tract (URT) conditions. Administration of histamine and methacholine aerosols resulted in significant changes in all factor scores, although most of the observed changes were due to the effects of these aerosols on the respiratory rate. These findings re-emphasize the importance of the effects of respiratory rate on pulmonary mechanics. Application of the resistance resulted in significant changes in factor score 3, the 'inspiratory' factor, which lends support to the validity of this model for URT conditions. The close agreement between the factor scores obtained under controlled conditions in this study and in a previous study in this laboratory confirms that the factor analysis used for both of these studies provides an adequate means of reducing TBFVL data obtained from thoroughbred horses. The large intra- and inter-individual variation observed both with the indices of TBFVL and with the factor scores limits the potential of these variables for detecting individual animals with obstructive airway disease. Re-evaluation of these indices under the stress of exercise may reduce the variability observed in these data and may increase the magnitude of differences between different animals, providing a means of detecting individual animals with subclinical obstructive airway conditions.
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Publication Date: 1995-01-01 PubMed ID: 8619290DOI: 10.1007/BF01839340Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article investigates the effects of three models of airway disease on the breathing patterns of thoroughbred horses. The three models tested were induced through the administration of histamine, methacholine aerosols, and a fixed inspiratory resistance.

Objective of the Study

  • The objective of the study was to assess the effects of histamine, methacholine aerosols, and a static inspiratory resistance on the tidal breathing flow-volume loops (TBFVL) of 18 healthy, unsedated, standing thoroughbred horses.

Testing and Methods

  • The researchers first analyzed the results using traditional flow-volume loop indices.
  • The data was then standardized using factor scoring coefficients from a previous study performed in the same laboratory using similar experimental techniques.
  • The resting TBFVL analysis was used to gauge the level of pulmonary dysfunction caused by the inhalation of histamine and methacholine aerosols at concentrations of 10 and 2 mg/ml, respectively.

Results of the Study

  • The study found that the histamine and methacholine aerosols induced a similar degree of lung dysfunction when analyzed based on resting TBFVL.
  • A fixed inspiratory resistance also led to significant changes in the resting spirogram and TBFVL indices, making it a potentially useful model for further study involving upper respiratory tract (URT) conditions.
  • Administering the aerosols resulted in noticeable changes in all factor scores, primarily due to the aerosols’ influence on the breathing rate.
  • This result highlights the significance of respiratory rate on lung mechanics.
  • Applying the fixed resistance led to significant changes in factor score 3, the ‘inspiratory’ factor, reinforcing the validity of this model when studying URT conditions.

Implications and Conclusions

  • The factor analysis used in this and a previous study offer an efficient way to simplify TBFVL data from thoroughbred horses.
  • However, large variations, both within and between individuals, in both the TBFVL indices and the factor scores limit these variables’ potential in identifying individual animals with obstructive airway disease.
  • The researchers suggested that re-evaluating these indices during exercise might reduce the observed variability in the data and make it easier to discern differences between different animals. This could provide a way to detect individual horses with less obvious obstructive airway conditions.

Cite This Article

APA
Guthrie AJ, Beadle RE, Bateman RD, White CE. (1995). The effects of three models of airway disease on tidal breathing flow-volume loops of thoroughbred horses. Vet Res Commun, 19(6), 517-527. https://doi.org/10.1007/BF01839340

Publication

Veterinary research communications
ISSN: 0165-7380
NlmUniqueID: 8100520
Country: Switzerland
Language: English
Volume: 19
Issue: 6
Pages: 517-527

Researcher Affiliations

Guthrie, A J
  • Department of Veterinary Physiology, Pharmacology and Toxicology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803, USA.
Beadle, R E
    Bateman, R D
      White, C E

        MeSH Terms

        • Administration, Inhalation
        • Aerosols
        • Airway Resistance / physiology
        • Animals
        • Bronchoconstrictor Agents / administration & dosage
        • Bronchoconstrictor Agents / toxicity
        • Disease Models, Animal
        • Expiratory Reserve Volume / physiology
        • Female
        • Histamine / administration & dosage
        • Histamine / toxicity
        • Horse Diseases / chemically induced
        • Horse Diseases / physiopathology
        • Horses
        • Male
        • Methacholine Chloride / administration & dosage
        • Methacholine Chloride / toxicity
        • Peak Expiratory Flow Rate / physiology
        • Random Allocation
        • Respiratory System / physiopathology
        • Respiratory Tract Diseases / chemically induced
        • Respiratory Tract Diseases / physiopathology
        • Respiratory Tract Diseases / veterinary
        • Tidal Volume / physiology

        References

        This article includes 17 references
        1. Abramson AL, Goldstein MN, Stenzler A, Steele A. The use of the tidal breathing flow volume loop in laryngotracheal disease of neonates and infants.. Laryngoscope 1982 Aug;92(8 Pt 1):922-6.
          pubmed: 7098740
        2. Petsche VM, Derksen FJ, Robinson NE. Tidal breathing flow-volume loops in horses with recurrent airway obstruction (heaves).. Am J Vet Res 1994 Jul;55(7):885-91.
          pubmed: 7978623
        3. Stadler P, Deegen E. Diurnal variation of dynamic compliance, resistance and viscous work of breathing in normal horses and horses with lung disorders.. Equine Vet J 1986 May;18(3):171-8.
          pubmed: 3732235doi: 10.1111/j.2042-3306.1986.tb03587.xgoogle scholar: lookup
        4. Guthrie AJ, Beadle RE, Bateman RD, White CE. Characterization of normal tidal breathing flow-volume loops for thoroughbred horses.. Vet Res Commun 1995;19(4):331-42.
          pubmed: 8540244doi: 10.1007/BF01839315google scholar: lookup
        5. Connally BA, Derksen FJ. Tidal breathing flow-volume loop analysis as a test of pulmonary function in exercising horses.. Am J Vet Res 1994 May;55(5):589-94.
          pubmed: 8067603
        6. Jackson AC, Vinegar A. A technique for measuring frequency response of pressure, volume, and flow transducers.. J Appl Physiol Respir Environ Exerc Physiol 1979 Aug;47(2):462-7.
          pubmed: 468704doi: 10.1152/jappl.1979.47.2.462google scholar: lookup
        7. Derksen FJ, Robinson NE, Slocombe RF, Riebold TW, Brunson DB. Pulmonary function tests in standing ponies: reproducibility and effect of vagal blockade.. Am J Vet Res 1982 Apr;43(4):598-602.
          pubmed: 7073080
        8. Gillespie JR, Tyler WS, Eberly VE. Pulmonary ventilation and resistance in emphysematous and control horses.. J Appl Physiol 1966 Mar;21(2):416-22.
          pubmed: 5949047doi: 10.1152/jappl.1966.21.2.416google scholar: lookup
        9. Lumsden JM, Derksen FJ, Stick JA, Robinson NE. Use of flow-volume loops to evaluate upper airway obstruction in exercising standardbreds.. Am J Vet Res 1993 May;54(5):766-75.
          pubmed: 8317771
        10. Amis TC, Smith MM, Gaber CE, Kurpershoek C. Upper airway obstruction in canine laryngeal paralysis.. Am J Vet Res 1986 May;47(5):1007-10.
          pubmed: 3717719
        11. Art T, Lekeux P. Respiratory airflow patterns in ponies at rest and during exercise.. Can J Vet Res 1988 Jul;52(3):299-303.
          pubmed: 3167715
        12. Amis TC, Kurpershoek C. Tidal breathing flow-volume loop analysis for clinical assessment of airway obstruction in conscious dogs.. Am J Vet Res 1986 May;47(5):1002-6.
          pubmed: 3717718
        13. Takishima T, Grimby G, Graham W, Knudson R, Macklem PT, Mead J. Flow-volume curves during quiet breathing, maximum voluntary ventilation, and forced vital capacities in patients with obstructive lung disease.. Scand J Respir Dis 1967;48(3):384-93.
          pubmed: 5183633
        14. Beadle RE, Guthrie AJ, Kou AH. Characterization of a density-corrected ultrasonic pneumotachometer for horses.. J Appl Physiol (1985) 1995 Jan;78(1):359-67.
          pubmed: 7713837doi: 10.1152/jappl.1995.78.1.359google scholar: lookup
        15. Amis TC, Kurpershoek C. Pattern of breathing in brachycephalic dogs.. Am J Vet Res 1986 Oct;47(10):2200-4.
          pubmed: 3777646
        16. Raphel CF, Soma LR. Exercise-induced pulmonary hemorrhage in Thoroughbreds after racing and breezing.. Am J Vet Res 1982 Jul;43(7):1123-7.
          pubmed: 7103190
        17. Guthrie AJ, Beadle RE, Bateman RD, White CE. Temporal effects of inhaled histamine and methacholine aerosols on the pulmonary mechanics of thoroughbred horses.. J Vet Pharmacol Ther 1992 Dec;15(4):317-31.
          pubmed: 1487831doi: 10.1111/j.1365-2885.1992.tb01024.xgoogle scholar: lookup

        Citations

        This article has been cited 2 times.
        1. Tilley P, Simões J, Sales Luis JP. Effects of a 15° Variation in Poll Flexion during Riding on the Respiratory Systems and Behaviour of High-Level Dressage and Show-Jumping Horses. Animals (Basel) 2023 May 22;13(10).
          doi: 10.3390/ani13101714pubmed: 37238147google scholar: lookup
        2. Secombe C, Adler A, Hosgood G, Raisis A, Mosing M. Can bronchoconstriction and bronchodilatation in horses be detected using electrical impedance tomography?. J Vet Intern Med 2021 Jul;35(4):2035-2044.
          doi: 10.1111/jvim.16152pubmed: 33977584google scholar: lookup
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