Evaluation of osteochondral sample collection guided by computed tomography and magnetic resonance imaging for early detection of osteoarthritis in centrodistal joints of young Icelandic horses.
Abstract: To evaluate the use of CT and MRI for guidance of osteochondral sample collection for histologic detection of early osteoarthritic lesions in centrodistal (distal intertarsal) joints of horses. Methods: Right tarsal joints from the cadavers of 24 Icelandic horses aged 29 to 31 months. Methods: CT and MRI were used to evaluate the extent of suspected osteoarthritic changes in centrodistal joints, which were graded with a semiquantitative system. The anatomic regions with the highest grade of change were identified, and osteochondral samples were obtained from these regions. Samples were also obtained from the same centrodistal joints at predetermined sites. Histologic examination of all samples was performed, with samples classified as negative or positive for osteoarthritis, and results were compared between sample collection methods. Results: Histologic examination revealed osteoarthritic lesions in 29% (7/24) of centrodistal joints with the predetermined method and in 63% (15/24) with the image-guided method. Significant associations were identified between histologic osteoarthritis detection and the summed image-guided sample collection site image grades, central osteophytes, articular cartilage thickness abnormalities, grade 2 articular mineralization front defects, and grade 2 marginal osteophytes. Conclusions: CT and MRI aided the detection of focal changes suggestive of early-stage osteoarthritis in the centrodistal joints of equine cadavers and may be useful for detection of similar disease in live horses. The first morphological changes of centrodistal joint osteoarthritis were suspected to be in the articular cartilage and the articular mineralization front regions.
Publication Date: 2013-05-31 PubMed ID: 23718656DOI: 10.2460/ajvr.74.6.874Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research article is centered on investigating the use of computed tomography (CT) and magnetic resonance imaging (MRI) for early detection of osteoarthritic changes in horses.
Objective of the Study
- The main cause of this study is to verify the efficiency of using CT and MRI for guiding osteochondral sample collection and recognizing the early stages of osteoarthritic filthiness in centrodistal joints of horses.
Methodology
- The research involved 24 Icelandic horse cadavers aged between 29 and 31 months. The right tarsal joint of each cadaver was the focus.
- CT and MRI were exploited to ascertain the prevalence of suspected early osteoarthritic changes in the centrodistal joints.
- A semi-quantitative system was formulated to grade osteoarthritic changes. Anatomical regions showing the highest grade of deformation were identified.
- Osteochondral samples were gathered from these anatomical regions. The study also collected samples from pre-decided sites of the same centrodistal joints.
- A histologic examination of all obtained samples was performed. Samples were distinguished as negative or positive for osteoarthritis for comparison purposes.
Results
- Histologic examination showed osteoarthritic lesions in 29% of centrodistal joints using the predetermined method, and in 63% of these joints using the image-guided method.
- Significant relationships were identified between osteoarthritis detection and various attributes such as the image-guided sample collection site image grades, central osteophytes, articular cartilage thickness abnormalities, grade 2 articular mineralization front defects, and grade 2 marginal osteophytes.
Conclusions
- The research concluded that CT and MRI could help detect focal changes that suggest early-stage osteoarthritis in the centrodistal joints of equine cadavers. This means they could be beneficial for sensing similar diseases in live horses.
- The first morphological changes due to osteoarthritis in centrodistal joint were supposed to be in the articular cartilage and the articular mineralization front regions.
Cite This Article
APA
Ley CJ, Ekman S, Dahlberg LE, Björnsdóttir S, Hansson K.
(2013).
Evaluation of osteochondral sample collection guided by computed tomography and magnetic resonance imaging for early detection of osteoarthritis in centrodistal joints of young Icelandic horses.
Am J Vet Res, 74(6), 874-887.
https://doi.org/10.2460/ajvr.74.6.874 Publication
Researcher Affiliations
- Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, SE-750 07, Sweden. charles.ley@slu.se
MeSH Terms
- Animals
- Cartilage / pathology
- Horse Diseases / diagnosis
- Horse Diseases / pathology
- Horses
- Joints / pathology
- Magnetic Resonance Imaging / veterinary
- Osteoarthritis / diagnosis
- Osteoarthritis / veterinary
- Sensitivity and Specificity
- Tomography, X-Ray Computed / veterinary
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