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Home / Equine Research Bank / Animals (Basel) / Evaluation of Plasmatic Procalcitonin in Healthy, and in Sys...
Animals : an open access journal from MDPI2021; 11(7); 2015; doi: 10.3390/ani11072015

Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses.

Abstract: Colic horses show systemic inflammatory response syndrome (SIRS) clinical signs. Procalcitonin (PCT) showed increased circulating levels in sick horses. This study compares plasma PCT concentrations in healthy vs. SIRS negative/positive colic horses over time, and evaluates PCT and SIRS score potential correlation, to verify the usefulness of PCT for the evaluation of SIRS severity. Ninety-one horses were included; 43/91 were healthy, on basis of physical examination, blood work and SIRS score (score = 0), while 48/91 were sick colic horses, classified as SIRS-negative (score < 2) and positive (score ≥ 2). Moreover, a 0-6 point-scale SIRS score was calculated (assessing mucous membrane color and blood lactate concentration). PCT was evaluated at admission, and at 24, 48, 72 and 96 h, using a commercial kit for equine species. We verified by the ANOVA test PCT differences between healthy vs. colic horses, healthy vs. SIRS-negative or SIRS-positive colic horses, at all sampling times, and the correlation between the SIRS score at admission with the SIRS score. Statistically significant differences were detected between healthy vs. all colic horses and between healthy vs. SIRS-positive or negative horses at all sampling times. No correlation was observed between the SIRS score at admission and PCT values. PCT was statistically higher in colic horses compared to the healthy ones, suggesting a role as a biomarker for colic.
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Publication Date: 2021-07-06 PubMed ID: 34359143PubMed Central: PMC8300415DOI: 10.3390/ani11072015Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article looks at how concentrations of the protein Procalcitonin (PCT) in the bloodstreams of healthy horses compare to those of horses suffering from colic and systemic inflammatory response syndrome (SIRS), in an effort to ascertain the potential of PCT as an indicator, or biomarker, for such conditions.

Overview of the Study

  • This research involved 91 horses, 43 of which were healthy (shown through physical examination, blood work, and a SIRS score of zero) and the remaining 48 were suffering from colic. The colic horses were further classified as SIRS negative (a score of less than two) or SIRS positive (a score of two or higher).
  • In an effort to evaluate the SIRS severity, a 0-6 scale SIRS score was calculated, which took into account the color of the horses’ mucous membranes and the concentration of lactate in their blood.
  • PCT concentrations were gauged upon admission, and at 24, 48, 72 and 96 hour intervals using a commercial kit designed for equine species.
  • These measurements allowed for comparison of PCT levels in healthy horses and those with colic, as well as between healthy horses and those categorized as SIRS negative and those as SIRS positive at all sample times.

Findings from the Research

  • When applying the ANOVA test, the study found significant differences between PCT concentrations in the healthy horses versus those with colic and those with SIRS (both positive and negative) at all sample times.
  • Despite evaluating the potential correlation between the SIRS score at admission and PCT values, the study did not find a significant correlation between these two.

Implications of the Study’s Results

  • The sharply higher levels of PCT found in the colic horses relative to the healthy ones offers promise for the use of PCT as a biomarker indicating the presence of colic.
  • However, without a clear correlation between the SIRS score at admission and the PCT values, PCT concentrations may not offer as clear an indication of SIRS severity, warranting further investigation and study.

Cite This Article

APA
(2021). Evaluation of Plasmatic Procalcitonin in Healthy, and in Systemic Inflammatory Response Syndrome (SIRS) Negative or Positive Colic Horses. Animals (Basel), 11(7), 2015. https://doi.org/10.3390/ani11072015

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 11
Issue: 7
PII: 2015

Researcher Affiliations

Conflict of Interest Statement

The authors declare no conflict of interest.

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Citations

This article has been cited 7 times.
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