Evaluation of the effect of extracorporeal shock wave treatment on experimentally induced osteoarthritis in middle carpal joints of horses.
Abstract: OBJECTIVE-To assess the clinical, biochemical, and histologic effects of extracorporeal shock wave therapy (ESWT) in the treatment of horses with experimentally induced osteoarthritis (OA). ANIMALS-Twenty-four 2- to 3-year-old horses without evidence of lameness. PROCEDURES-OA was induced arthroscopically in 1 middle carpal joint of each horse. Fourteen days after induction of OA, horses were treated with a sham ESWT probe (placebo; n = 8), polysulfated glycosaminoglycan (PSGAG) administered IM every 4 days for 28 days as a positive control treatment (8), or ESWT administered on days 14 and 28 with a focused shock wave unit (8). Evaluations included clinical assessments of degree of lameness every 2 weeks and weekly synovial fluid analyses. Horses were euthanized 70 days after induction of OA, and gross pathologic and histologic examinations of cartilage and synovial membrane specimens were performed at necropsy. A generalized linear mixed model was used to compare outcomes among treatment groups. RESULTS-No adverse treatment-related events were detected in any horse. The degree of lameness in horses treated with ESWT improved significantly, compared with the degree of lameness in placebo- or PSGAG-treated horses. No disease-modifying effects were evident in results for synovial fluid, synovial membranes, or cartilage from the ESWT- or PSGAG-treated horses. CONCLUSIONS AND CLINICAL RELEVANCE-Although a disease-modifying effect of ESWT was not detected, the significant clinical effect of ESWT suggested that this modality should be considered for treatment of horses with OA in combination with another modality that does affect the disease process.
Publication Date: 2009-04-02 PubMed ID: 19335099DOI: 10.2460/ajvr.70.4.449Google Scholar: Lookup
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- Journal Article
Summary
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The research study primarily seeks to assess the impact of extracorporeal shock wave therapy (ESWT) on horses that were experimentally induced with osteoarthritis (OA). Through this research, it was observed that ESWT significantly improved the lameness condition of horses but did not exhibit any signs of influencing the disease process.
Objective and Methodology
- The primary aim of the research was to evaluate the clinical, biochemical, and histopathological effects of extracorporeal shock wave therapy (ESWT) on horses experimentally afflicted with osteoarthritis (OA).
- The study was conducted on twenty-four 2- to 3-year-old horses that exhibited no signs of lameness. OA was artificially induced in the middle carpal joint of each of these horses.
- The horses were divided into three groups for treatment: a placebo group that underwent sham ESWT (8 horses), a group treated with polysulfated glycosaminoglycan (PSGAG) administrated IM every 4 days for 28 days as a positive control treatment (8 horses), and a group that received ESWT on days 14 and 28 using a focused shock wave unit (8 horses).
- A variety of evaluations were made including assessments of the degree of lameness every 2 weeks and weekly synovial fluid analyses. Post 70 days of the OA induction, the horses were euthanized, and their cartilage and synovial membrane specimens were examined.
Findings and Conclusion
- There were no adverse events detected in the horses related to the treatments. ESWT considerably improved the degree of lameness in horses in comparison to the placebo or PSGAG-treated ones. However, no effects were detected on the disease process in results for synovial fluid, synovial membranes, or cartilage for the ESWT or PSGAG treated horses The study concluded that while ESWT had substantial clinical effect it did not show any influence on the progression of the disease itself.
- The researchers suggested that ESWT should be considered for treating horses with OA but in combination with another treatment strategy that can directly influence the disease process.n
Cite This Article
APA
Frisbie DD, Kawcak CE, McIlwraith CW.
(2009).
Evaluation of the effect of extracorporeal shock wave treatment on experimentally induced osteoarthritis in middle carpal joints of horses.
Am J Vet Res, 70(4), 449-454.
https://doi.org/10.2460/ajvr.70.4.449 Publication
Researcher Affiliations
- Equine Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
MeSH Terms
- Animals
- Carpus, Animal / injuries
- Carpus, Animal / pathology
- Cartilage, Articular / pathology
- Glycosaminoglycans / administration & dosage
- Glycosaminoglycans / therapeutic use
- High-Energy Shock Waves / therapeutic use
- Horse Diseases / drug therapy
- Horse Diseases / pathology
- Horse Diseases / therapy
- Horses
- Lameness, Animal / classification
- Lameness, Animal / therapy
- Osteoarthritis / drug therapy
- Osteoarthritis / pathology
- Osteoarthritis / therapy
- Osteoarthritis / veterinary
- Random Allocation
- Synovial Fluid / chemistry
Citations
This article has been cited 18 times.- Boström A, Bergh A, Hyytiäinen H, Asplund K. Systematic Review of Complementary and Alternative Veterinary Medicine in Sport and Companion Animals: Extracorporeal Shockwave Therapy.. Animals (Basel) 2022 Nov 12;12(22).
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- Jhan SW, Wang CJ, Wu KT, Siu KK, Ko JY, Huang WC, Chou WY, Cheng JH. Comparison of Extracorporeal Shockwave Therapy with Non-Steroid Anti-Inflammatory Drugs and Intra-Articular Hyaluronic Acid Injection for Early Osteoarthritis of the Knees.. Biomedicines 2022 Jan 18;10(2).
- MacKay AV, McOnie RC, Riddell LP, Robinson KA. Characterization of the use of shock wave therapy among equine veterinarians.. Can Vet J 2020 Sep;61(9):990-993.
- Li T, Ma J, Zhao T, Gao F, Sun W. Application and efficacy of extracorporeal shockwave treatment for knee osteoarthritis: A systematic review and meta-analysis.. Exp Ther Med 2019 Oct;18(4):2843-2850.
- Qi H, Jin S, Yin C, Chen L, Sun L, Liu Y. Radial extracorporeal shock wave therapy promotes osteochondral regeneration of knee joints in rabbits.. Exp Ther Med 2018 Oct;16(4):3478-3484.
- Lee JK, Lee BY, Shin WY, An MJ, Jung KI, Yoon SR. Effect of Extracorporeal Shockwave Therapy Versus Intra-articular Injections of Hyaluronic Acid for the Treatment of Knee Osteoarthritis.. Ann Rehabil Med 2017 Oct;41(5):828-835.
- Hsu SL, Cheng JH, Wang CJ, Ko JY, Hsu CH. Extracorporeal Shockwave Therapy Enhances Expression of Pdia-3 Which Is a Key Factor of the 1α,25-Dihydroxyvitamin D 3 Rapid Membrane Signaling Pathway in Treatment of Early Osteoarthritis of the Knee.. Int J Med Sci 2017;14(12):1220-1230.
- Yılmaz V, Karadaş Ö, Dandinoğlu T, Umay E, Çakçı A, Tan AK. Efficacy of extracorporeal shockwave therapy and low-intensity pulsed ultrasound in a rat knee osteoarthritis model: A randomized controlled trial.. Eur J Rheumatol 2017 Jun;4(2):104-108.
- Wang CJ, Cheng JH, Huang CY, Hsu SL, Lee FY, Yip HK. Medial tibial subchondral bone is the key target for extracorporeal shockwave therapy in early osteoarthritis of the knee.. Am J Transl Res 2017;9(4):1720-1731.
- Wang CJ, Cheng JH, Chou WY, Hsu SL, Chen JH, Huang CY. Changes of articular cartilage and subchondral bone after extracorporeal shockwave therapy in osteoarthritis of the knee.. Int J Med Sci 2017;14(3):213-223.
- Cho SJ, Yang JR, Yang HS, Yang HE. Effects of Extracorporeal Shockwave Therapy in Chronic Stroke Patients With Knee Osteoarthritis: A Pilot Study.. Ann Rehabil Med 2016 Oct;40(5):862-870.
- Cheng JH, Wang CJ, Su SH, Huang CY, Hsu SL. Next-generation sequencing identifies articular cartilage and subchondral bone miRNAs after ESWT on early osteoarthritis knee.. Oncotarget 2016 Dec 20;7(51):84398-84407.
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- Wang CJ, Hsu SL, Weng LH, Sun YC, Wang FS. Extracorporeal shockwave therapy shows a number of treatment related chondroprotective effect in osteoarthritis of the knee in rats.. BMC Musculoskelet Disord 2013 Jan 28;14:44.
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