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Journal of veterinary internal medicine2018; 32(3); 1185-1193; doi: 10.1111/jvim.15087

Evaluation of updated sepsis scoring systems and systemic inflammatory response syndrome criteria and their association with sepsis in equine neonates.

Abstract: The original equine sepsis score provided a method of identifying foals with sepsis. New variables associated with sepsis have been evaluated, but the sepsis score has not been updated. Objective: To evaluate the sensitivity and specificity of 2 updated sepsis scores and the systemic inflammatory response syndrome (SIRS) criteria in regard to detecting sepsis in foals. Methods: Two-hundred and seventy-three ill foals and 25 healthy control foals. Methods: Historical, physical examination, and clinicopathologic findings were used to calculate the original sepsis score and 2 updated sepsis scores. SIRS criteria were also evaluated. Sepsis scores and positive SIRS scores were statistically compared to foals with sepsis. Results: One-hundred and twenty-six foals were septic and 147 sick-nonseptic. The original and updated sepsis scores were significantly higher in septic foals as compared to sick-nonseptic and healthy foals. The sensitivity and specificity of the updated sepsis scores to predict sepsis were not significantly better than those of the original sepsis score. One-hundred and twenty-seven of 273 (46.5%) foals met the original SIRS criteria and 88/273 (32%) foals met the equine neonatal SIRS criteria. The original SIRS criteria had similar sensitivity and specificity for predicting sepsis as did the 3 sepsis scores in our study. Conclusions: The updated sepsis scores did not provide improved ability in predicting sepsis. Fulfilling the original SIRS criteria provided similar sensitivity and specificity in predicting sepsis as the modified sepsis score and might serve as a diagnostic aid in identifying foals at risk for sepsis.
Copyright © 2018 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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Publication Date: 2018-03-26 PubMed ID: 29582480PubMed Central: PMC5980351DOI: 10.1111/jvim.15087Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article investigates the accuracy of updated sepsis scoring systems and the Systemic Inflammatory Response Syndrome (SIRS) criteria in detecting sepsis in equine neonates (baby horses), concluding that the updated sepsis scoring systems did not improve sensitivity and specificity in predicting sepsis compared to the original criteria.

Background

  • The primary objective of this research was to evaluate the sensitivity and specificity of two updated sepsis scores, and also the SIRS criteria, and their association with sepsis in equine neonates.
  • The study involved a total of 273 foals that appeared to be ill and 25 foals who were healthy, serving as control subjects.

Methodology

  • Data such as the foals’ historical details, physical examination results, and clinicopathologic findings were used to calculate the original sepsis score and 2 updated sepsis scores.
  • The researchers also evaluated the SIRS criteria and their indication towards sepsis.
  • Statistical comparisons were made between the sepsis scores, the positive SIRS scores, and the actual cases of sepsis.

Results

  • Out of the total foals studied, 126 were found to be septic, and 147 were classified as sick-nonseptic.
  • Both the original and updated sepsis scores were significantly higher in septic foals compared to sick-nonseptic and healthy foals.
  • However, the sensitivity and specificity of the updated sepsis scores in predicting sepsis did not improve over that of the original sepsis score.
  • Approximately 46.5% foals met the original SIRS criteria and 32% foals met the equine neonatal SIRS criteria. The sensitivity and specificity of the SIRS criteria bore resemblance to the sepsis scores in the study.

Conclusions

  • The research concluded that the updated sepsis scores did not contribute to an improved prediction of sepsis in equine neonates.
  • The original SIRS criteria had similar sensitivity and specificity for predicting sepsis compared with the 3 sepsis scores.
  • The study suggests that fulfilling the original SIRS criteria might serve as a useful diagnostic aid in identifying foals at risk of developing sepsis.

Cite This Article

APA
Wong DM, Ruby RE, Dembek KA, Barr BS, Reuss SM, Magdesian KG, Olsen E, Burns T, Slovis NM, Wilkins PA. (2018). Evaluation of updated sepsis scoring systems and systemic inflammatory response syndrome criteria and their association with sepsis in equine neonates. J Vet Intern Med, 32(3), 1185-1193. https://doi.org/10.1111/jvim.15087

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 32
Issue: 3
Pages: 1185-1193

Researcher Affiliations

Wong, D M
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Lloyd Veterinary Medical Center, Iowa State University, Ames, Iowa.
Ruby, R E
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Lloyd Veterinary Medical Center, Iowa State University, Ames, Iowa.
Dembek, K A
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Lloyd Veterinary Medical Center, Iowa State University, Ames, Iowa.
Barr, B S
  • Department of Internal Medicine, Rood and Riddle Equine Hospital, Lexington, Kentucky.
Reuss, S M
  • Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida.
Magdesian, K G
  • Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California.
Olsen, E
  • Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca, New York.
Burns, T
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio.
Slovis, N M
  • McGee Medicine Center, Hagyard Equine Medical Institute, Lexington, Kentucky.
Wilkins, P A
  • Department of Veterinary Clinical Medicine, University of Illinois, Urbana, Illinois.

MeSH Terms

  • Animals
  • Animals, Newborn
  • Female
  • Horse Diseases / classification
  • Horse Diseases / diagnosis
  • Horse Diseases / microbiology
  • Horses
  • Male
  • Sensitivity and Specificity
  • Sepsis / classification
  • Sepsis / diagnosis
  • Sepsis / microbiology
  • Sepsis / veterinary
  • Severity of Illness Index
  • Systemic Inflammatory Response Syndrome / classification
  • Systemic Inflammatory Response Syndrome / diagnosis
  • Systemic Inflammatory Response Syndrome / microbiology
  • Systemic Inflammatory Response Syndrome / veterinary

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Citations

This article has been cited 30 times.
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