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Home / Equine Research Bank / Vet Microbiol / Extended-spectrum β-lactamase, carbapenemase and AmpC ...
Veterinary microbiology2014; 170(1-2); 10-18; doi: 10.1016/j.vetmic.2014.01.017

Extended-spectrum β-lactamase, carbapenemase and AmpC producing Enterobacteriaceae in companion animals.

Abstract: Organisms in the family Enterobactericeae including, Escherichia coli, commonly cause community and hospital-associated infections in both humans and companion animals. The increasing prevalence of infections with organisms producing broad spectrum β-lactamses such as the ESBLs (particularly the CTX-M type), AmpC and carbapenemase enzymes are threatening the future of the β-lactam drugs. While a number of organisms within the Enterobacteriaceae producing these enzymes have been isolated from cats, dogs and horses, E. coli, including isolates indistinguishable from strains found in people, has most frequently been described in the literature. Although little is known about the prevalence of colonization, or incidence of infections with these organisms in companion animals, the growing body of literature suggests that they are increasing. Transmission of these organisms to and from humans into companion animals has not been adequately described, although significant public and animal health concerns exist.
Copyright © 2014 Elsevier B.V. All rights reserved.
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Publication Date: 2014-02-02 PubMed ID: 24576841DOI: 10.1016/j.vetmic.2014.01.017Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This article examines the rise in antibiotic-resistant bacteria, primarily E. coli, in domestic pets. The researchers are concerned about the spread of these bacteria and the potential risks to both human and animal health.

Overview of Research Focus

  • The research paper focuses on the rising incidence of antibiotic-resistant bacteria within Enterobacteriaceae, a large family of bacteria including E. coli, which commonly cause both hospital and community-associated infections in humans and companion animals.

Reason for Concern

  • The study raises concern about the growing prevalence of bacteria producing enzymes such as ESBLs (Extended-spectrum β-lactamases), AmpC, and carbapenemases that reduce the effect of β-lactam antibiotics. This occurrence threatens the future utility and effectiveness of β-lactam drugs.
  • Particularly worrying is the CTX-M type of ESBL which is seen to be increasingly produced by these bacteria.

Identification in Companion Animals

  • The research paper notes that such resistant bacteria have been isolated from companion animals such as cats, dogs, and horses. E. coli, whose strains can be identical to those found in humans, is often identified in these cases.

Gaps in Current Knowledge

  • The paper also points out the lack of knowledge about the rates of colonization and infection by these antibiotic-resistant organisms in pets. Despite this lack, the growing body of literature suggests a rising trend.

Transmission to Humans

  • Pertinently, the transmission of these resistant organisms between humans and companion animals remains poorly understood. Nonetheless, such a transmission poses significant health risk implications both for public health and animal health, due to the potential spread of antibiotic resistance.

Cite This Article

APA
Rubin JE, Pitout JD. (2014). Extended-spectrum β-lactamase, carbapenemase and AmpC producing Enterobacteriaceae in companion animals. Vet Microbiol, 170(1-2), 10-18. https://doi.org/10.1016/j.vetmic.2014.01.017

Publication

Veterinary microbiology
ISSN: 1873-2542
NlmUniqueID: 7705469
Country: Netherlands
Language: English
Volume: 170
Issue: 1-2
Pages: 10-18
PII: S0378-1135(14)00052-2

Researcher Affiliations

Rubin, Joseph E
  • Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada; Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address: joe.rubin@usask.ca.
Pitout, Johann D D
  • Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada; Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada.

MeSH Terms

  • Animals
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Drug Resistance, Bacterial / genetics
  • Enterobacteriaceae / enzymology
  • Enterobacteriaceae / genetics
  • Enterobacteriaceae / isolation & purification
  • Enterobacteriaceae Infections / microbiology
  • Enterobacteriaceae Infections / transmission
  • Humans
  • Pets / microbiology
  • Zoonoses / microbiology
  • Zoonoses / transmission
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism

Citations

This article has been cited 43 times.
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