Full-Genome Sequence of a Neuroinvasive West Nile Virus Lineage 2 Strain from a Fatal Horse Infection in South Africa.
Abstract: We report here the complete genome sequence of a lineage 2 West Nile virus (WNV) strain that resulted in fatal neurological disease in a horse in South Africa. Several recent reports exist of neurological disease associated with lineage 2 WNV in humans and horses in South Africa and Europe; however, there are a lack of sequencing data from recent fatal cases in Southern Africa, where these strains likely originate. A better understanding of the genetic composition of highly neuroinvasive lineage 2 strains may facilitate the identification of putative genetic factors associated with increased virulence.
Copyright © 2016 Mentoor et al.
Publication Date: 2016-07-28 PubMed ID: 27469963PubMed Central: PMC4966467DOI: 10.1128/genomeA.00740-16Google Scholar: Lookup
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- Journal Article
Summary
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The research reports on the full-genome sequence of a highly virulent strain of West Nile Virus, lineage 2, responsible for a fatal neurological disease in a horse from South Africa.
Objective and Purpose of the Study
- The study was conducted to investigate the complete genome sequence of a particular strain of West Nile Virus (WNV), known as lineage 2.
- This strain was identified to be the cause for fatal neurological disease in a horse in South Africa.
- There have been several reports of neurological diseases associated with lineage 2 WNV in humans and horses both in South Africa and Europe.
- However, there is a lack of sequencing data, especially from recent fatal cases in Southern Africa, where these strains of the virus are believed to originate.
- Ultimately, the purpose of the study was to gain a better understanding of the genetic make-up of the highly neuroinvasive lineage 2 strains.
- This could potentially help in identifying specific genetic factors associated with the virus’ increased virulence.
Implications and Significance of the Study
- The reported complete genome sequence may fill the data gap of the lineage 2 strain of the West Nile Virus, particularly from the Southern African region where the strains are suspected to originate from.
- This study may allow for a broader and more accurate understanding of the biological characteristics of the lineage 2 WNV.
- This could be particularly useful for the development of diagnostic tools, treatments, and preventive measures against the disease.
- Identifying the genetic factors related to heightened virulence could lead to the possibility of a more targeted and effective treatment for infections caused by this strain of the virus.
- It may also contribute to the global understanding of lineage 2 WNV’s spread and its potential threats to both human and animal health.
Cite This Article
APA
Mentoor JL, Lubisi AB, Gerdes T, Human S, Williams JH, Venter M.
(2016).
Full-Genome Sequence of a Neuroinvasive West Nile Virus Lineage 2 Strain from a Fatal Horse Infection in South Africa.
Genome Announc, 4(4), e00740-16.
https://doi.org/10.1128/genomeA.00740-16 Publication
Researcher Affiliations
- Zoonosis Research Unit, Department Medical Virology, University of Pretoria, Pretoria, South Africa.
- Virology Molecular Epidemiology and Diagnostics Programme, Agricultural Research Council, Onderstepoort Veterinary Institute, Pretoria, South Africa.
- Virology Molecular Epidemiology and Diagnostics Programme, Agricultural Research Council, Onderstepoort Veterinary Institute, Pretoria, South Africa.
- Zoonosis Research Unit, Department Medical Virology, University of Pretoria, Pretoria, South Africa.
- Department of Paraclinical Sciences, Faculty of Veterinary Sciences, University of Pretoria, Pretoria, South Africa.
- Zoonosis Research Unit, Department Medical Virology, University of Pretoria, Pretoria, South Africa Centre for Global Disease Detection, South Africa, Division of Global Health Protection, Centers for Disease Control and Prevention, Pretoria, South Africa yds8@cdc.gov.
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Citations
This article has been cited 1 times.- Byaruhanga T, Astbury S, Hill JD, Tsoleridis T, Chappell JG, Kayiwa JT, Ataliba IJ, Nankya AM, Ball JK, Lutwama JJ, McClure CP. Undiagnosed West Nile virus lineage 2d infection in a febrile patient from South-west Uganda, 2018. IJID Reg 2024 Dec;13:100462.
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