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Journal of veterinary internal medicine2015; 29(6); 1648-1659; doi: 10.1111/jvim.13616

Genetic Susceptibility to Rhodococcus equi.

Abstract: Rhodococcus equi pneumonia is a major cause of morbidity and mortality in neonatal foals. Much effort has been made to identify preventative measures and new treatments for R. equi with limited success. With a growing focus in the medical community on understanding the genetic basis of disease susceptibility, investigators have begun to evaluate the interaction of the genetics of the foal with R. equi. This review describes past efforts to understand the genetic basis underlying R. equi susceptibility and tolerance. It also highlights the genetic technology available to study horses and describes the use of this technology in investigating R. equi. This review provides readers with a foundational understanding of candidate gene approaches, single nucleotide polymorphism-based, and copy number variant-based genome-wide association studies, and next generation sequencing (both DNA and RNA).
Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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Publication Date: 2015-09-04 PubMed ID: 26340305PubMed Central: PMC4895676DOI: 10.1111/jvim.13616Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article reviews efforts to understand the genetic factors that make foals susceptible or resistant to Rhodococcus equi pneumonia and the use of modern genetic technology in this area of investigation.

Investigating Genetic Susceptibility to Rhodococcus equi Pneumonia

The article begins by emphasizing the significance of Rhodococcus equi pneumonia in new-born foals, both in terms of morbidity and mortality. There have been attempts made to prevent this disease and create new treatment methods, but these have been met with limited success. As such, the current trend in the medical sector is to understand disease vulnerability from a genetic point of view.

  • This includes studying the genetic composition of foals and how it interacts with R. equi, which is the focus of this research.
  • The authors also delve into past studies that aimed to discern the genetic factors that influence susceptibility to and tolerance of R. equi.
  • This dual approach of prevention and cure alongside an understanding of genetic variability forms the basis of the research article.

Application of Genetic Technology in Research

The paper also explores the role of advanced genetic technologies in this field of research.

  • The authors expound on how these technologies can be utilized in horse genetics studies and, more specifically, in R. equi investigations.
  • The review provides insight into a range of genetic approaches used including candidate gene approaches, genome-wide association studies that focus on single nucleotide polymorphisms and copy number variants, and next-generation sequencing approaches (both DNA and RNA).
  • These techniques provide the researchers with comprehensive insights into the genetic suspense to R. equi. This understanding, in turn, may aid in finding preventative measures and targeted treatments for the disease.

In essence, the paper is an in-depth review of the genetic underpinnings of R. equi susceptibility in foals, the various genomics technologies that can be effectively employed to deepen the understanding of this interaction, and the potential courses of action to combat this disease in the light of these findings.

Cite This Article

APA
McQueen CM, Dindot SV, Foster MJ, Cohen ND. (2015). Genetic Susceptibility to Rhodococcus equi. J Vet Intern Med, 29(6), 1648-1659. https://doi.org/10.1111/jvim.13616

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 29
Issue: 6
Pages: 1648-1659

Researcher Affiliations

McQueen, C M
  • Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX.
Dindot, S V
  • Department of Veterinary Pathobiology, Texas A&M University, College Station, TX.
Foster, M J
  • Medical Sciences Library, Texas A&M University, College Station, TX.
Cohen, N D
  • Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX.

MeSH Terms

  • Actinomycetales Infections / genetics
  • Actinomycetales Infections / microbiology
  • Actinomycetales Infections / veterinary
  • Animals
  • Genetic Predisposition to Disease
  • Horse Diseases / genetics
  • Horse Diseases / microbiology
  • Horses
  • Rhodococcus equi

References

This article includes 96 references
  1. Prescott JF. Rhodococcus equi: an animal and human pathogen.. Clin Micro Rev 1991;4:20–34.
    pmc: PMC358176pubmed: 2004346
  2. Hurley JR, Begg AP. Failure of hyperimmune plasma to prevent pneumonia caused by Rhodococcus equi in foals.. Aust Vet J 1995;72:418–420.
    pubmed: 8929188
  3. Venner M, Reinhold B, Beyerbach M. Efficacy of azithromycin in preventing pulmonary abscesses in foals.. Vet J 2009;179:301–303.
    pubmed: 18023599
  4. Chaffin MK, Cohen ND, Martens RJ. Evaluation of the efficacy of gallium maltolate for chemoprophylaxis against pneumonia caused by Rhodococcus equi infection in foals.. Am J Vet Res 2011;72:945–957.
    pubmed: 21728856
  5. Burton AJ, Giguère S, Sturgill TL. Macrolide‐ and rifampin‐resistant Rhodococcus equi on a horse breeding farm, Kentucky, USA.. Emerg Infect Dis 2013;19:282–285.
    pmc: PMC3559061pubmed: 23347878
  6. Giguère S, Cohen ND, Chaffin MK. Rhodococcus equi: clinical manifestations, virulence, and immunity.. J Vet Intern Med 2011;25:1221–1230.
    pubmed: 22092609
  7. Giguère S, Hondalus MK, Yager JA. Role of the 85‐kilobase plasmid and plasmid‐encoded virulence‐associated protein A in intracellular survival and virulence of Rhodococcus equi .. Infect Immun 1999;67:3548–3557.
    pmc: PMC116543pubmed: 10377138
  8. Jain S, Bloom BR, Hondalus MK. Deletion of vapA encoding Virulence Associated Protein A attenuates the intracellular actinomycete Rhodococcus equi .. Mol Microbiol 2003;50:115–128.
    pubmed: 14507368
  9. Cohen ND, Smith KE, Ficht TA. Epidemiologic study of results of pulsed‐field gel electrophoresis of isolates of Rhodococcus equi obtained from horses and horse farms.. Am J Vet Res 2003;64:153–161.
    pubmed: 12602583
  10. Bolton T, Kuskie K, Halbert N. Detection of strain variation in isolates of Rhodococcus equi from an affected foal using repetitive sequence‐based polymerase chain reaction.. J Vet Diag Inv 2010;22:611–615.
    pubmed: 20622235
  11. Morton AC, Begg AP, Anderson GA. Epidemiology of Rhodococcus equi strains on Thoroughbred horse farms.. Appl Environ Microbiol 2001;67:2167–2175.
    pmc: PMC92851pubmed: 11319096
  12. Cohen ND, Carter CN, Scott HM. Association of soil concentrations of Rhodococcus equi and incidence of pneumonia attributable to Rhodococcus equi in foals on farms in central Kentucky.. Am J Vet Res 2008;69:385–395.
    pubmed: 18312138
  13. Muscatello G, Anderson GA, Gilkerson JR. Associations between the ecology of virulent Rhodococcus equi and the epidemiology of R. equi pneumonia on Australian thoroughbred farms.. Appl Environ Microbiol 2006;72:6152–6160.
    pmc: PMC1563629pubmed: 16957241
  14. Boyd NK, Cohen ND, Lim WS. Temporal changes in cytokine expression of foals during the first month of life.. Vet Immunol Immunopathol 2003;92:75–85.
    pubmed: 12628765
  15. Breathnach CC, Sturgill‐Wright T, Stiltner JL. Foals are interferon gamma‐deficient at birth.. Vet Immunol Immunopathol 2006;112:199–209.
    pubmed: 16621024
  16. Stewart GR, Robertson BD, Young DB. Tuberculosis: a problem with persistence.. Nat Rev Microbiol 2003;1:97–105.
    pubmed: 15035039
  17. Tabor HK, Risch NJ, Myers RM. Candidate‐gene approaches for studying complex genetic traits: practical considerations.. Nat Rev Genet 2002;3:391–397.
    pubmed: 11988764
  18. Kwon JM, Goate AM. The candidate gene approach.. Alcohol Res Health 2000;24:164–168.
    pmc: PMC6709736pubmed: 11199286
  19. Mousel MR, Harrison L, Donahue JM. Rhodococcus equi and genetic susceptibility: assessing transferrin genotypes from paraffin‐embedded tissues.. J Vet Diag Invest 2003;15:470–472.
    pubmed: 14535549
  20. de Jong G, van Dijk JP, van Eijk HG. The biology of transferrin.. Clin Chim Acta 1990;190:1–46.
    pubmed: 2208733
  21. Skaar EP. The battle for iron between bacterial pathogens and their vertebrate hosts.. PLoS Pathog 2010;6:e1000949.
    pmc: PMC2920840pubmed: 20711357
  22. Horin P, Smola J, Matiasovic J. Polymorphisms in equine immune response genes and their associations with infections.. Mamm Genome 2004;15:843–850.
    pubmed: 15520887
  23. Blackwell JM, Goswami T, Evans CA. SLC11A1 (formerly NRAMP1) and disease resistance.. Cell Microbiol 2001;3:773–784.
    pmc: PMC3025745pubmed: 11736990
  24. Blackwell JM, Searle S, Mohamed H. Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story.. Immunol Lett 2003;85:197–203.
    pubmed: 12527228
  25. Vidal S, Tremblay ML, Govoni G. The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.. J Exp Med 1995;182:655–666.
    pmc: PMC2192162pubmed: 7650477
  26. Adams LG, Templeton JW. Genetic resistance to bacterial diseases of animals.. Rev Sci Tec 1998;17:200–219.
    pubmed: 9638811
  27. Forbes JR, Gros P. Divalent‐metal transport by NRAMP proteins at the interface of host‐pathogen interactions.. Trends Microbiol 2001;9:397–403.
    pubmed: 11514223
  28. Blackwell JM, Searle S, Goswami T. Understanding the multiple functions of Nramp1.. Microbes Infect 2000;2:317–321.
    pubmed: 10758409
  29. Halbert ND, Cohen ND, Slovis NM. Variations in equid SLC11A1 (NRAMP1) genes and associations with Rhodococcus equi pneumonia in horses.. J Vet Intern Med 2006;20:974–979.
    pubmed: 16955825
  30. Horin P, Sabakova K, Futas J. Immunity‐related gene single nucleotide polymorphisms associated with Rhodococcus equi infection in foals.. Int J Immunogenet 2010;37:67–71.
    pubmed: 20002811
  31. Lander ES, Linton LM, Birren B. Initial sequencing and analysis of the human genome.. Nature 2001;409:860–921.
    pubmed: 11237011
  32. Wade CM, Giulotto E, Sigurdsson S. Genome sequence, comparative analysis, and population genetics of the domestic horse.. Science 2009;326:865–867.
    pmc: PMC3785132pubmed: 19892987
  33. Elsik CG, Tellam RL, Worley KC. The genome sequence of taurine cattle: a window to ruminant biology and evolution.. Science 2009;324:522–528.
    pmc: PMC2943200pubmed: 19390049
  34. Waterston RH, Lindblad‐Toh K, Birney E. Initial sequencing and comparative analysis of the mouse genome.. Nature 2002;420:520–562.
    pubmed: 12466850
  35. Consortium TGP. A map of human genome variation from population‐scale sequencing.. Nature 2010;467:1061–1073.
    pmc: PMC3042601pubmed: 20981092
  36. Gibbs RA, Taylor JF, Van Tassell CP. Genome‐wide survey of SNP variation uncovers the genetic structure of cattle breeds.. Science 2009;324:528–532.
    pmc: PMC2735092pubmed: 19390050
  37. LaFramboise T. Single nucleotide polymorphism arrays: a decade of biological, computational and technological advances.. Nucleic Acids Res 2009;37:4181–4193.
    pmc: PMC2715261pubmed: 19570852
  38. Barsh GS, Copenhaver GP, Gibson G. Guidelines for genome‐wide association studies.. PLoS Genet 2012;8:e1002812.
    pmc: PMC3390399pubmed: 22792080
  39. McCue ME, Bannasch DL, Petersen JL. A high density SNP array for the domestic horse and extant perissodactyla: utility for association mapping, genetic diversity, and phylogeny studies.. PLoS Genet 2012;8:e1002451.
    pmc: PMC3257288pubmed: 22253606
  40. Finno CJ, Bannasch DL. Applied equine genetics.. Equine Vet J 2014;46:538–544.
    pmc: PMC4327934pubmed: 24802051
  41. Go YY, Bailey E, Cook DG. Genome‐wide association study among four horse breeds identifies a common haplotype associated with in vitro CD3+ T cell susceptibility/resistance to equine arteritis virus infection.. J Virol 2011;85:13174–13184.
    pmc: PMC3233183pubmed: 21994447
  42. Hauswirth R, Haase B, Blatter M. Mutations in MITF and PAX3 cause “splashed white” and other white spotting phenotypes in horses.. PLoS Genet 2012;8:e1002653.
    pmc: PMC3325211pubmed: 22511888
  43. Hill EW, McGivney BA, Gu J. A genome‐wide SNP‐association study confirms a sequence variant (g.66493737C>T) in the equine myostatin (MSTN) gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorses.. BMC Genom 2010;11:552.
    pmc: PMC3091701pubmed: 20932346
  44. Lykkjen S, Dolvik NI, McCue ME. Genome‐wide association analysis of osteochondrosis of the tibiotarsal joint in Norwegian Standardbred trotters.. Anim Genet 2010;41(Suppl 2):111–120.
    pubmed: 21070284
  45. Raudsepp T, McCue ME, Das PJ. Genome‐wide association study implicates testis‐sperm specific FKBP6 as a susceptibility locus for impaired acrosome reaction in stallions.. PLoS Genet 2012;8:e1003139.
    pmc: PMC3527208pubmed: 23284302
  46. Lykkjen S, Dolvik NI, McCue ME. Equine developmental orthopaedic diseases ‐ a genome‐wide association study of first phalanx plantar osteochondral fragments in Standardbred trotters.. Anim Genet 2013;44:766–769.
    pubmed: 23742657
  47. Slatkin M. Linkage disequilibrium–understanding the evolutionary past and mapping the medical future.. Nat Rev Genet 2008;9:477–485.
    pmc: PMC5124487pubmed: 18427557
  48. Petersen JL, Mickelson JR, Cothran EG. Genetic diversity in the modern horse illustrated from genome‐wide SNP data.. PLoS ONE 2013;8:e54997.
    pmc: PMC3559798pubmed: 23383025
  49. Kruglyak L. Prospects for whole‐genome linkage disequilibrium mapping of common disease genes.. Nat Genet 1999;22:139–144.
    pubmed: 10369254
  50. Chanock SJ, Manolio T, Boehnke M. Replicating genotype-phenotype associations.. Nature 2007;447:655–660.
    pubmed: 17554299
  51. Manolio TA, Brooks LD, Collins FS. A HapMap harvest of insights into the genetics of common disease.. J Clin Invest 2008;118:1590–1605.
    pmc: PMC2336881pubmed: 18451988
  52. McQueen CM, Doan R, Dindot SV. Identification of Genomic Loci Associated with Rhodococcus equi Susceptibility in Foals.. PLoS ONE 2014;9:e98710.
    pmc: PMC4043894pubmed: 24892408
  53. Chaffin MK, Cohen ND, Blodgett GP. Evaluation of ultrasonagraphic screening methods for early detection of Rhodococcus equi pneumonia in foals.. J Equine Vet Sci 2012;32:S20–S21 (Abstract).
  54. Yamamoto S, Shimizu S, Kiyonaka S. TRPM2‐mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration.. Nat Med 2008;14:738–747.
    pmc: PMC2789807pubmed: 18542050
  55. Hastings PJ, Lupski JR, Rosenberg SM. Mechanisms of change in gene copy number.. Nat Rev Genet 2009;10:551–564.
    pmc: PMC2864001pubmed: 19597530
  56. Hastings PJ, Ira G, Lupski JR. A microhomology‐mediated break‐induced replication model for the origin of human copy number variation.. PLoS Genet 2009;5:e1000327.
    pmc: PMC2621351pubmed: 19180184
  57. Lupski JR. Structural Variation in the Human Genome.. N Engl J Med 2007;356:1169–1171.
    pubmed: 17360997
  58. Feuk L, Carson AR, Scherer SW. Structural variation in the human genome.. Nat Rev Genet 2006;7:85–97.
    pubmed: 16418744
  59. Stankiewicz P, Lupski JR. Genome architecture, rearrangements and genomic disorders.. Trends Genet 2002;18:74–82.
    pubmed: 11818139
  60. Weterings E, van Gent DC. The mechanism of non‐homologous end‐joining: a synopsis of synapsis.. DNA Repair 2004;3:1425–1435.
    pubmed: 15380098
  61. Haviv‐Chesner A, Kobayashi Y, Gabriel A. Capture of linear fragments at a double‐strand break in yeast.. Nucleic Acids Res 2007;35:5192–5202.
    pmc: PMC1976456pubmed: 17670800
  62. McVey M, Lee SE. MMEJ repair of double‐strand breaks (director's cut): deleted sequences and alternative endings.. Trends Genet 2008;24:529–538.
    pmc: PMC5303623pubmed: 18809224
  63. Lee JA, Carvalho CM, Lupski JR. A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders.. Cell 2007;131:1235–1247.
    pubmed: 18160035
  64. Sheen CR, Jewell UR, Morris CM. Double complex mutations involving F8 and FUNDC2 caused by distinct break‐induced replication.. Hum Mutat 2007;28:1198–1206.
    pubmed: 17683067
  65. Dupuis MC, Zhang Z, Durkin K. Detection of copy number variants in the horse genome and examination of their association with recurrent laryngeal neuropathy.. Anim Genet 2013;44:206–208.
    pubmed: 22582820
  66. Metzger J, Philipp U, Lopes MS. Analysis of copy number variants by three detection algorithms and their association with body size in horses.. BMC Genom 2013;14:487.
    pmc: PMC3720552pubmed: 23865711
  67. Kato M, Kawaguchi T, Ishikawa S. Population‐genetic nature of copy number variations in the human genome.. Hum Mol Gen 2010;19:761–773.
    pmc: PMC2816609pubmed: 19966329
  68. Mills RE, Walter K, Stewart C. Mapping copy number variation by population‐scale genome sequencing.. Nature 2011;470:59–65.
    pmc: PMC3077050pubmed: 21293372
  69. Carter NP. Methods and strategies for analyzing copy number variation using DNA microarrays.. Nat Genet 2007;39:S16–S21.
    pmc: PMC2697494pubmed: 17597776
  70. Doan R, Cohen ND, Sawyer J. Whole‐genome sequencing and genetic variant analysis of a Quarter Horse mare.. BMC Genom 2012;13:78.
    pmc: PMC3309927pubmed: 22340285
  71. Doan R, Cohen N, Harrington J. Identification of copy number variants in horses.. Genome Res 2012;22:899–907.
    pmc: PMC3337435pubmed: 22383489
  72. Ghosh S, Qu Z, Das PJ. Copy number variation in the horse genome.. PLoS Genet 2014;10:e1004712.
    pmc: PMC4207638pubmed: 25340504
  73. Wang W, Wang S, Hou C. Genome‐wide detection of copy number variations among diverse horse breeds by array CGH.. PLoS ONE 2014;9:e86860.
    pmc: PMC3907382pubmed: 24497987
  74. Park KD, Kim H, Hwang JY. Copy number deletion has little impact on gene expression levels in racehorses.. Asian‐Aust J Anim Sci 2014;27:1345–1354.
    pmc: PMC4150202pubmed: 25178379
  75. Rosengren Pielberg G, Golovko A, Sundstrom E. A cis‐acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse.. Nat Genet 2008;40:1004–1009.
    pubmed: 18641652
  76. Olsson M, Meadows JR, Truve K. A novel unstable duplication upstream of HAS2 predisposes to a breed‐defining skin phenotype and a periodic fever syndrome in Chinese Shar‐Pei dogs.. PLoS Genet 2011;7:e1001332.
    pmc: PMC3060080pubmed: 21437276
  77. Hehir‐Kwa JY, Pfundt R, Veltman JA. Pathogenic or not? Assessing the clinical relevance of copy number variants.. Clin Genet 2013;84:415–421.
    pubmed: 23895381
  78. Krepischi AC, Pearson PL, Rosenberg C. Germline copy number variations and cancer predisposition.. Future Oncol 2012;8:441–450.
    pubmed: 22515447
  79. Liu GE, Bickhart DM. Copy number variation in the cattle genome.. Funct Integr Genomics 2012;12:609–624.
    pubmed: 22790923
  80. Metzker ML. Emerging technologies in DNA sequencing.. Genome Res 2005;15:1767–1776.
    pubmed: 16339375
  81. Sanger F, Nicklen S, Coulson AR. DNA sequencing with chain‐terminating inhibitors.. Proc Nat Acad Sci USA 1977;74:5463–5467.
    pmc: PMC431765pubmed: 271968
  82. Metzker ML. Sequencing technologies ‐ the next generation.. Nat Rev Genet 2010;11:31–46.
    pubmed: 19997069
  83. Anders S, Huber W. Differential expression analysis for sequence count data.. Genome Biol 2010;11:R106.
    pmc: PMC3218662pubmed: 20979621
  84. Trapnell C, Roberts A, Goff L. Differential gene and transcript expression analysis of RNA‐seq experiments with TopHat and Cufflinks.. Nat Protocols 2012;7:562–578.
    pmc: PMC3334321pubmed: 22383036
  85. Katz Y, Wang ET, Airoldi EM. Analysis and design of RNA sequencing experiments for identifying isoform regulation.. Nat Meth 2010;7:1009–1015.
    pmc: PMC3037023pubmed: 21057496
  86. Capomaccio S, Vitulo N, Verini‐Supplizi A. RNA sequencing of the exercise transcriptome in equine athletes.. PLoS ONE 2013;8:e83504.
    pmc: PMC3877044pubmed: 24391776
  87. Park KD, Park J, Ko J. Whole transcriptome analyses of six thoroughbred horses before and after exercise using RNA‐Seq.. BMC Genom 2012;13:473.
    pmc: PMC3472166pubmed: 22971240
  88. Bellone RR, Holl H, Setaluri V. Evidence for a retroviral insertion in TRPM1 as the cause of congenital stationary night blindness and leopard complex spotting in the horse.. PLoS ONE 2013;8:e78280.
    pmc: PMC3805535pubmed: 24167615
  89. Das PJ, McCarthy F, Vishnoi M. Stallion sperm transcriptome comprises functionally coherent coding and regulatory RNAs as revealed by microarray analysis and RNA‐seq.. PLoS ONE 2013;8:e56535.
    pmc: PMC3569414pubmed: 23409192
  90. Iqbal K, Chitwood JL, Meyers‐Brown GA. RNA‐seq transcriptome profiling of equine inner cell mass and trophectoderm.. Biol Reprod 2014;90:61.
    pmc: PMC4435230pubmed: 24478389
  91. Leise BS, Watts MR, Roy S. Use of laser capture microdissection for the assessment of equine lamellar basal epithelial cell signalling in the early stages of laminitis.. Equine Vet J 2015;47:478–488.
    pmc: PMC4771185pubmed: 24750316
  92. Park W, Kim J, Kim HJ. Investigation of de novo unique differentially expressed genes related to evolution in exercise response during domestication in Thoroughbred race horses.. PLoS ONE 2014;9:e91418.
    pmc: PMC3962374pubmed: 24658125
  93. Peffers M, Liu X, Clegg P. Transcriptomic signatures in cartilage ageing.. Arthritis Res Ther 2013;15:R98.
    pmc: PMC3978620pubmed: 23971731
  94. Coleman SJ, Zeng Z, Wang K. Structural annotation of equine protein‐coding genes determined by mRNA sequencing.. Anim Genet 2010;41(Suppl 2):121–130.
    pubmed: 21070285
  95. Moreton J, Malla S, Aboobaker AA. Characterisation of the horse transcriptome from immunologically active tissues.. PeerJ 2014;2:e382.
    pmc: PMC4017814pubmed: 24860704
  96. Hanash S. Disease proteomics.. Nature 2003;422:226–232.
    pubmed: 12634796

Citations

This article has been cited 7 times.
  1. Villalba-Orero M, Gómez CA, Valero-Gónzalez M, Venegas N, Criado G, Martín-Cuervo M. Blood parameters in neonatal foal and colostrum quality as possible early markers for increased risk of developing Rhodococcus equi pneumonia. Front Vet Sci 2025;12:1654052.
    doi: 10.3389/fvets.2025.1654052pubmed: 40948621google scholar: lookup
  2. da Silveira BP, Cohen ND, Lawhon SD, Watson RO, Bordin AI. Protective immune response against Rhodococcus equi: An innate immunity-focused review. Equine Vet J 2025 May;57(3):563-586.
    doi: 10.1111/evj.14214pubmed: 39258739google scholar: lookup
  3. Rakowska A, Marciniak-Karcz A, Bereznowski A, Cywińska A, Żychska M, Witkowski L. Less Typical Courses of Rhodococcus equi Infections in Foals. Vet Sci 2022 Oct 31;9(11).
    doi: 10.3390/vetsci9110605pubmed: 36356082google scholar: lookup
  4. Vail KJ, da Silveira BP, Bell SL, Cohen ND, Bordin AI, Patrick KL, Watson RO. The opportunistic intracellular bacterial pathogen Rhodococcus equi elicits type I interferon by engaging cytosolic DNA sensing in macrophages. PLoS Pathog 2021 Sep;17(9):e1009888.
    doi: 10.1371/journal.ppat.1009888pubmed: 34473814google scholar: lookup
  5. Rakowska A, Cywinska A, Witkowski L. Current Trends in Understanding and Managing Equine Rhodococcosis. Animals (Basel) 2020 Oct 18;10(10).
    doi: 10.3390/ani10101910pubmed: 33081047google scholar: lookup
  6. Schaefer RJ, Schubert M, Bailey E, Bannasch DL, Barrey E, Bar-Gal GK, Brem G, Brooks SA, Distl O, Fries R, Finno CJ, Gerber V, Haase B, Jagannathan V, Kalbfleisch T, Leeb T, Lindgren G, Lopes MS, Mach N, da Câmara Machado A, MacLeod JN, McCoy A, Metzger J, Penedo C, Polani S, Rieder S, Tammen I, Tetens J, Thaller G, Verini-Supplizi A, Wade CM, Wallner B, Orlando L, Mickelson JR, McCue ME. Developing a 670k genotyping array to tag ~2M SNPs across 24 horse breeds. BMC Genomics 2017 Jul 27;18(1):565.
    doi: 10.1186/s12864-017-3943-8pubmed: 28750625google scholar: lookup
  7. McQueen CM, Whitfield-Cargile CM, Konganti K, Blodgett GP, Dindot SV, Cohen ND. TRPM2 SNP genotype previously associated with susceptibility to Rhodococcus equi pneumonia in Quarter Horse foals displays differential gene expression identified using RNA-Seq. BMC Genomics 2016 Dec 5;17(1):993.
    doi: 10.1186/s12864-016-3345-3pubmed: 27919223google scholar: lookup
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