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Home / Equine Research Bank / J Vet Intern Med / Genetic Susceptibility to Rhodococcus equi.
Journal of veterinary internal medicine2015; 29(6); 1648-1659; doi: 10.1111/jvim.13616

Genetic Susceptibility to Rhodococcus equi.

Abstract: Rhodococcus equi pneumonia is a major cause of morbidity and mortality in neonatal foals. Much effort has been made to identify preventative measures and new treatments for R. equi with limited success. With a growing focus in the medical community on understanding the genetic basis of disease susceptibility, investigators have begun to evaluate the interaction of the genetics of the foal with R. equi. This review describes past efforts to understand the genetic basis underlying R. equi susceptibility and tolerance. It also highlights the genetic technology available to study horses and describes the use of this technology in investigating R. equi. This review provides readers with a foundational understanding of candidate gene approaches, single nucleotide polymorphism-based, and copy number variant-based genome-wide association studies, and next generation sequencing (both DNA and RNA).
Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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Publication Date: 2015-09-04 PubMed ID: 26340305PubMed Central: PMC4895676DOI: 10.1111/jvim.13616Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article reviews efforts to understand the genetic factors that make foals susceptible or resistant to Rhodococcus equi pneumonia and the use of modern genetic technology in this area of investigation.

Investigating Genetic Susceptibility to Rhodococcus equi Pneumonia

The article begins by emphasizing the significance of Rhodococcus equi pneumonia in new-born foals, both in terms of morbidity and mortality. There have been attempts made to prevent this disease and create new treatment methods, but these have been met with limited success. As such, the current trend in the medical sector is to understand disease vulnerability from a genetic point of view.

  • This includes studying the genetic composition of foals and how it interacts with R. equi, which is the focus of this research.
  • The authors also delve into past studies that aimed to discern the genetic factors that influence susceptibility to and tolerance of R. equi.
  • This dual approach of prevention and cure alongside an understanding of genetic variability forms the basis of the research article.

Application of Genetic Technology in Research

The paper also explores the role of advanced genetic technologies in this field of research.

  • The authors expound on how these technologies can be utilized in horse genetics studies and, more specifically, in R. equi investigations.
  • The review provides insight into a range of genetic approaches used including candidate gene approaches, genome-wide association studies that focus on single nucleotide polymorphisms and copy number variants, and next-generation sequencing approaches (both DNA and RNA).
  • These techniques provide the researchers with comprehensive insights into the genetic suspense to R. equi. This understanding, in turn, may aid in finding preventative measures and targeted treatments for the disease.

In essence, the paper is an in-depth review of the genetic underpinnings of R. equi susceptibility in foals, the various genomics technologies that can be effectively employed to deepen the understanding of this interaction, and the potential courses of action to combat this disease in the light of these findings.

Cite This Article

APA
McQueen CM, Dindot SV, Foster MJ, Cohen ND. (2015). Genetic Susceptibility to Rhodococcus equi. J Vet Intern Med, 29(6), 1648-1659. https://doi.org/10.1111/jvim.13616

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 29
Issue: 6
Pages: 1648-1659

Researcher Affiliations

McQueen, C M
  • Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX.
Dindot, S V
  • Department of Veterinary Pathobiology, Texas A&M University, College Station, TX.
Foster, M J
  • Medical Sciences Library, Texas A&M University, College Station, TX.
Cohen, N D
  • Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX.

MeSH Terms

  • Actinomycetales Infections / genetics
  • Actinomycetales Infections / microbiology
  • Actinomycetales Infections / veterinary
  • Animals
  • Genetic Predisposition to Disease
  • Horse Diseases / genetics
  • Horse Diseases / microbiology
  • Horses
  • Rhodococcus equi

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Citations

This article has been cited 7 times.
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