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The Veterinary clinics of North America. Equine practice2020; 36(2); 289-301; doi: 10.1016/j.cveq.2020.03.008

Genetics of Equine Orthopedic Disease.

Abstract: Orthopedic diseases are a common cause for limited exercise capacity in the horse. They often underlie genetic risk factors, which can affect bone, articular cartilage, tendons, ligaments, and adnexal structures among others. The genetic effects can directly interfere with tissue development and skeletal growth or can trigger degenerative or inflammatory processes. Many of these diseases of the locomotor system like osteochondrosis are complex and can be affected by multifactorial influences. For this reason, it is important for those performing diagnostic procedures to have a comprehensive knowledge of orthopedic diseases, their prevalence within breeds, and genetic background.
Publication Date: 2020-06-11 PubMed ID: 32534855DOI: 10.1016/j.cveq.2020.03.008Google Scholar: Lookup
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Summary

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This study delves into the role of genetics in equine orthopedic conditions, which can greatly impede a horse’s physical activity. It emphasizes the importance for diagnosticians to be well-versed about these conditions, their commonality in certain breeds, and their genetic basis.

Importance of Understanding Equine Orthopedic Diseases

  • The research paper emphasizes the importance of extensively understanding equine orthopedic diseases. Such ailments are often responsible for reducing the performance and physical activity of horses. They may end up impacting the horse’s ligaments, bones, tendons, articular cartilage and adjoining structure due to underlying genetic factors.
  • The knowledge of these diseases and their prevalence in certain breeds is crucial for those involved in diagnostic procedures, given the complexity of these conditions and variable impact.

Role of Genetics in Equine Orthopedic Diseases

  • The study discusses how these orthopedic diseases are often resulted from pre-existing genetic risk factors. These genetic factors can either directly meddle with the development of tissues and growth of skeletal structures in horses, or induce degenerative or inflammatory processes.
  • Complex conditions such as osteochondrosis are multifaceted, influenced by an array of factors. Thus, the research suggests a more comprehensive analysis and understanding of the genetic basis of these disorders for effective diagnosis.

Implications of Research

  • The findings of this research emphasize the importance of genetic studies in defining susceptibility to various orthopedic conditions in horses.
  • These insights could help to pave the way for improved diagnostic accuracy and targeted prevention strategies in equine healthcare.
  • In addition, an improved understanding of the genetic basis of these conditions could lead to the development of more effective treatment strategies, ultimately enhancing the welfare of the equine population.

Cite This Article

APA
Metzger J, Distl O. (2020). Genetics of Equine Orthopedic Disease. Vet Clin North Am Equine Pract, 36(2), 289-301. https://doi.org/10.1016/j.cveq.2020.03.008

Publication

ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 36
Issue: 2
Pages: 289-301
PII: S0749-0739(20)30019-5

Researcher Affiliations

Metzger, Julia
  • Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Buenteweg 17p, Hannover 30559, Germany. Electronic address: Julia.metzger@tiho-hannover.de.
Distl, Ottmar
  • Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Buenteweg 17p, Hannover 30559, Germany.

MeSH Terms

  • Animals
  • Cartilage, Articular / pathology
  • Horse Diseases / pathology
  • Horses
  • Musculoskeletal Diseases / genetics
  • Musculoskeletal Diseases / pathology
  • Musculoskeletal Diseases / veterinary
  • Osteochondrosis / genetics
  • Osteochondrosis / veterinary

Citations

This article has been cited 3 times.
  1. Momen M, Brauer K, Patterson MM, Sample SJ, Binversie EE, Davis BW, Cothran EG, Rosa GJM, Brounts SH, Muir P. Genetic architecture and polygenic risk score prediction of degenerative suspensory ligament desmitis (DSLD) in the Peruvian Horse.. Front Genet 2023;14:1201628.
    doi: 10.3389/fgene.2023.1201628pubmed: 37645058google scholar: lookup
  2. Momen M, Brounts SH, Binversie EE, Sample SJ, Rosa GJM, Davis BW, Muir P. Selection signature analyses and genome-wide association reveal genomic hotspot regions that reflect differences between breeds of horse with contrasting risk of degenerative suspensory ligament desmitis.. G3 (Bethesda) 2022 Sep 30;12(10).
    doi: 10.1093/g3journal/jkac179pubmed: 35866615google scholar: lookup
  3. Malekpour K, Hazrati A, Zahar M, Markov A, Zekiy AO, Navashenaq JG, Roshangar L, Ahmadi M. The Potential Use of Mesenchymal Stem Cells and Their Derived Exosomes for Orthopedic Diseases Treatment.. Stem Cell Rev Rep 2022 Mar;18(3):933-951.
    doi: 10.1007/s12015-021-10185-zpubmed: 34169411google scholar: lookup