Genome Sequence of the Attenuated Equid Alphaherpesvirus 1 Strain AK-2011, Isolated in Kazakhstan.
Abstract: In 2011, there was an outbreak of a disease with mass abortions among horses in southeastern Kazakhstan. The AK-2011 strain was isolated from an aborted fetus and subsequently identified as equid alphaherpesvirus 1. Here, we describe the nearly complete genome sequence of the AK-2011 strain, attenuated for vaccine development.
Publication Date: 2023-02-14 PubMed ID: 36786599PubMed Central: PMC10019157DOI: 10.1128/mra.01328-22Google Scholar: Lookup
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Summary
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This research article is about the obtaining and genetic sequencing of a weak strain of equid alphaherpesvirus 1, called AK-2011, isolated during an outbreak of a horse disease in Kazakhstan for the purposes of vaccine development.
Introduction
- The research was initiated following an outbreak of a disease among horses in southeastern Kazakhstan that led to many abortions.
- During this outbreak, a strain named AK-2011 was isolated from the foetus of an aborted horse.
- This strain was identified as equid alphaherpesvirus 1, a virus that causes reproductive and respiratory diseases in horses.
Genome Sequence of Strain AK-2011
- Researchers successfully obtained the nearly complete genome sequence of the AK-2011 strain.
- This genetic information provides insight into the structure and functions of the variant of the virus.
- Detailed analysis of the genome sequence can help in understanding the particular characteristics of this strain that may contribute to its pathogenicity and virulence.
Attenuated Strain For Vaccine Development
- The AK-2011 strain was attenuated, meaning it was manipulated in a laboratory to reduce its virulence or infectiousness, while still retaining enough characteristics to induce an immune response in a host organism.
- The goal of this attenuation process is to use this weakened strain in the development of a vaccine.
- This vaccine can potentially provide immunity to horses against equid alphaherpesvirus 1, helping in the prevention of future outbreaks of the disease.
Cite This Article
APA
Karamendin K, Abishov A, Kydyrmanov A, Akhmetzhanova M.
(2023).
Genome Sequence of the Attenuated Equid Alphaherpesvirus 1 Strain AK-2011, Isolated in Kazakhstan.
Microbiol Resour Announc, 12(3), e0132822.
https://doi.org/10.1128/mra.01328-22 Publication
Researcher Affiliations
- Laboratory of Viral Ecology, Scientific Production Center of Microbiology and Virology, LLP, Almaty, Kazakhstan.
- Kazakh National Agrarian Research University, Almaty, Kazakhstan.
- Virology Laboratory, SPE DiaVak-ABN, LLP, Almaty, Kazakhstan.
- Laboratory of Viral Ecology, Scientific Production Center of Microbiology and Virology, LLP, Almaty, Kazakhstan.
- Kazakh National Agrarian Research University, Almaty, Kazakhstan.
- Virology Laboratory, Antigen, LLP, Almaty, Kazakhstan.
Grant Funding
- BR10764975 / Ministry of Agriculture ot the Republic of Kazakhstan
Conflict of Interest Statement
The authors declare no conflict of interest.
References
This article includes 9 references
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