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Home / Equine Research Bank / PLoS One / Genomic screening of allelic and genotypic transmission rati...
PloS one2023; 18(8); e0289066; doi: 10.1371/journal.pone.0289066

Genomic screening of allelic and genotypic transmission ratio distortion in horse.

Abstract: The phenomenon in which the expected Mendelian inheritance is altered is known as transmission ratio distortion (TRD). The TRD analysis relies on the study of the transmission of one of the two alleles from a heterozygous parent to the offspring. These distortions are due to biological mechanisms affecting gametogenesis, embryo development and/or postnatal viability, among others. In this study, TRD phenomenon was characterized in horses using SNP-by-SNP model by TRDscan v.2.0 software. A total of 1,041 Pura Raza Español breed horses were genotyped with 554,634 SNPs. Among them, 277 horses genotyped in trios (stallion-mare-offspring) were used to perform the TRD analysis. Our results revealed 140 and 42 SNPs with allelic and genotypic patterns, respectively. Among them, 63 displayed stallion-TRD and 41 exhibited mare-TRD, while 36 SNPs showed overall TRD. In addition, 42 SNPs exhibited heterosis pattern. Functional analyses revealed that the annotated genes located within the TRD regions identified were associated with biological processes and molecular functions related to spermatogenesis, oocyte division, embryonic development, and hormonal activity. A total of 10 functional candidate genes related to fertility were found. To our knowledge, this is the most extensive study performed to evaluate the presence of alleles and functional candidate genes with transmission ratio distortion affecting reproductive performance in the domestic horse.
Copyright: © 2023 Laseca et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Publication Date: 2023-08-09 PubMed ID: 37556504PubMed Central: PMC10411798DOI: 10.1371/journal.pone.0289066Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study explores the phenomenon known as transmission ratio distortion (TRD) in horses, particularly, the Pura Raza Español breed. By analyzing the transmission of alleles from parent to offspring, the researchers identified genes associated with reproductive performance and fertility in the horse.

Research Methodology

  • The researchers used a particular breed of horse, the Pura Raza Español, for this study. This breed was chosen specifically because they have a high severity of equine diseases.
  • Around 1,041 of these horses were genotyped with more than half a million Single Nucleotide Polymorphisms (SNPs). SNPs are variations at single spots in a DNA sequence and can act as biological markers, helping scientists discover genes associated with certain diseases.
  • Out of all the horses genotyped, 277 horses were genotyped in trios consisting of a stallion, a mare, and their offspring. These groups were used to carry out the TRD analysis.

Findings

  • The analysis revealed 140 and 42 SNPs with allelic and genotypic patterns, respectively. An allelic pattern represents a variation in a genetic sequence, while a genotypic pattern indicates a specific gene’s form.
  • Some of these SNPs displayed a trend among certain parent-offspring pairs: 63 showed a tendency towards transmission from the stallion (male horse), 41 from the mare (female horse), and 36 showed a general trend of TRD irrespective of the parent.
  • An additional 42 SNPs exhibited a heterosis pattern, which is a phenomenon where the offspring’s genetic traits are superior to those of both parents.

Interpretation and Implications

  • By analyzing these patterns, the researchers identified that the genes found within the TRD regions were associated with biological activities such as spermatogenesis, oocyte division, embryonic development, and hormonal activity. These processes and functions are directly related to reproductive performance and fertility.
  • Ten functional candidate genes related to fertility were identified. These genes could potentially play a significant role in modifying or improving reproductive performance in horses.
  • This study contributes the most comprehensive evaluation of alleles and functional candidate genes with transmission ratio distortion affecting reproductive performance in horses. The findings could have significant implications for breeding and veterinary practices in the future.

Cite This Article

APA
Laseca N, Cánovas Á, Valera M, Id-Lahoucine S, Perdomo-González DI, Fonseca PAS, Demyda-Peyrás S, Molina A. (2023). Genomic screening of allelic and genotypic transmission ratio distortion in horse. PLoS One, 18(8), e0289066. https://doi.org/10.1371/journal.pone.0289066

Publication

PloS one
ISSN: 1932-6203
NlmUniqueID: 101285081
Country: United States
Language: English
Volume: 18
Issue: 8
Pages: e0289066
PII: e0289066

Researcher Affiliations

Laseca, Nora
  • Department of Genetics, University of Cordoba, Córdoba, Spain.
Cánovas, Ángela
  • Center of Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, Guelph, Ontario, Canada.
Valera, Mercedes
  • Department of Agronomy, School of Agronomy Engineering, University of Seville, Seville, Spain.
Id-Lahoucine, Samir
  • Department of Animal and Veterinary Science, Scotland's Rural College, Aberdeen, Scotland, United Kingdom.
Perdomo-González, Davinia I
  • Department of Agronomy, School of Agronomy Engineering, University of Seville, Seville, Spain.
Fonseca, Pablo A S
  • Department of Animal Production, University of Leon, León, Spain.
Demyda-Peyrás, Sebastián
  • Department of Genetics, University of Cordoba, Córdoba, Spain.
Molina, Antonio
  • Department of Genetics, University of Cordoba, Córdoba, Spain.

MeSH Terms

  • Horses / genetics
  • Animals
  • Male
  • Female
  • Alleles
  • Inheritance Patterns
  • Genotype
  • Heterozygote
  • Genomics

Conflict of Interest Statement

The authors have declared that no competing interests exist.

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