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Vaccine2013; 31(48); 5627-5633; doi: 10.1016/j.vaccine.2013.08.045

Global distribution of group A rotavirus strains in horses: a systematic review.

Abstract: Group A rotavirus (RVA) is a major cause of diarrhea and diarrhea-related mortality in foals in parts of the world. In addition to careful horse farm management, vaccination is the only known alternative to reduce the RVA associated disease burden on horse farms. The precise evaluation of vaccine effectiveness against circulating strains needs enhanced surveillance of equine RVAs in areas where vaccine is already available or vaccine introduction is anticipated. Therefore, we undertook the overview of relevant information on epidemiology of equine RVA strains through systematic search of public literature databases. Our findings indicated that over 99% of equine RVA strains characterized during the past three decades belonged to two common genotypes, G3P[12] and G14P[12], whereas most of the minority equine RVA strains were probably introduced from a heterologous host by interspecies transmission. These baseline data on RVA strains in horses shall contribute to a better understanding of the spatiotemporal dynamics of strain prevalence in vaccinated and non-vaccinated herds.
Copyright © 2013 Elsevier Ltd. All rights reserved.
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Publication Date: 2013-08-28 PubMed ID: 23994380DOI: 10.1016/j.vaccine.2013.08.045Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't
  • Review
  • Systematic Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research review highlights the widespread prevalence of Group A rotavirus (RVA) in horses, a main cause of diarrhoea-related illness and death. It shines a light on the importance of enhancing surveillance of equine RVA strains to assess vaccine effectiveness and prepare regions considering vaccine introduction.

Epidemiology of Equine RVA Strains

  • The researchers began by conducting a systematic review of the public literature databases to understand the epidemiological landscape of RVA strains in horses better.
  • Group A rotavirus is a significant pathogen causing severe diarrhea and related mortality in foals worldwide. Thus the study underscores the need to carefully manage horse farms and vaccinate against the disease.

Understanding Vaccine Effectiveness

  • Effective vaccination against RVA depends on precise evaluation of vaccine effectiveness against circulating strains.
  • This requires an up-to-date understanding of prevalent RVA strains, which can only be achieved through enhanced surveillance and ongoing research.
  • The study would hence help shape vaccination strategies in regions where vaccines are available and anticipate the needs of regions considering vaccine introduction.

Prevalence of RVA Strains in Horses

  • The review found that over 99% of equine RVA strains that have been characterized in the past three decades belonged to two primary genotypes, namely G3P[12] and G14P[12].
  • This observation is critical for vaccine production and administration because it’s necessary to ensure the administered vaccine matches the prevalent circulating viral strains to ensure its effectiveness.

Introduction of RVA Strains from Other Hosts

  • The majority of the minor equine RVA strains were likely introduced from a differently host via interspecies transmission.
  • The research findings further contribute to understanding the interspecies transmission dynamics of RVA, an important consideration for veterinary public health practices.

Outcomes and Future Implications

  • The findings from this study provide baseline data regarding the prevalence of RVA strains in horses, which are crucial for understanding how the strain prevalence changes over time and across different regions.
  • This data will also help in understanding the strain prevalence dynamics in vaccinated versus non-vaccinated herds, guiding future vaccination strategies.
  • A better understanding of RVA strain dynamics can contribute to better disease management and reduce RVA-related disease burden on horse farms.

Cite This Article

APA
Papp H, Matthijnssens J, Martella V, Ciarlet M, Bányai K. (2013). Global distribution of group A rotavirus strains in horses: a systematic review. Vaccine, 31(48), 5627-5633. https://doi.org/10.1016/j.vaccine.2013.08.045

Publication

Vaccine
ISSN: 1873-2518
NlmUniqueID: 8406899
Country: Netherlands
Language: English
Volume: 31
Issue: 48
Pages: 5627-5633
PII: S0264-410X(13)01136-5

Researcher Affiliations

Papp, Hajnalka
  • Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Hungária krt. 21, Budapest 1143, Hungary. Electronic address: suesy86@gmail.com.
Matthijnssens, Jelle
    Martella, Vito
      Ciarlet, Max
        Bányai, Krisztián

          MeSH Terms

          • Animals
          • Genotype
          • Global Health
          • Horse Diseases / epidemiology
          • Horse Diseases / virology
          • Horses
          • Molecular Epidemiology
          • Rotavirus / classification
          • Rotavirus / genetics
          • Rotavirus / isolation & purification
          • Rotavirus Infections / epidemiology
          • Rotavirus Infections / veterinary
          • Rotavirus Infections / virology

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          This article has been cited 26 times.
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