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Veterinary and human toxicology1996; 38(3); 204-206;

Heavy metal concentrations in injured racehorses.

Abstract: Records were reviewed of horses that had fatal injuries at California racetracks over a 16-mo period. Horses were categorized based on injury type, sex, age and breed. Arsenic, cadmium, copper, iron, lead, molybdenum and zinc concentrations were measured in the liver and kidneys from each horse. Arsenic and lead were not detected in any tissues. Liver heavy metal concentrations were not related to the injury type. Kidney iron concentrations were significantly (P < 0.05) higher in horses with ligament ruptures and in horses with fractured sesamoid, carpus or metacarpus/metatarsus bones. Liver cadmium, kidney cadmium, and liver iron were higher (P 2 y old than in 2-y-olds. Liver cadmium concentrations were higher (P < 0.05) in Thoroughbreds than in Quarter Horses.
Publication Date: 1996-06-01 PubMed ID: 8727221
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  • Journal Article

Summary

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The research investigated the concentration of various heavy metals in fatally injured racehorses in California within a period of 16 months, focusing on the horse’s age, breed, sex, and type of injury.

Research Methodology and Findings

  • The study involved a comprehensive review of horse records including the details like breed, sex, age, injury type and spectrometric determination of heavy metal concentrations in their liver and kidneys.
  • The heavy metals that were analyzed are arsenic, cadmium, copper, iron, lead, molybdenum and zinc. Interestingly, arsenic and lead were not detected in any of the tissue samples.
  • Analysis of these metals showed no direct correlation between liver heavy metal concentrations and the injury type of the horses, suggesting that incident of injury may not be directly attributed to metal toxicity in the liver.
  • The research found that kidney iron concentrations were significantly higher in horses that had ligament ruptures and those with bones fractures such as the sesamoid, metacarpus/metatarsus, and carpus bones. This indicates that higher iron concentrations in the kidney may be associated with certain types of injuries.

Age, Breed and Metal Concentration

  • The study also revealed significant differences in heavy metal concentrations depending on the age and breed of the horse. Liver cadmium, kidney cadmium, and liver iron were observed to be higher in horses older than two years compared to those that are only two-years-old.
  • In term of breed, the study observed that Thoroughbreds had higher liver cadmium concentrations compared to Quarter Horses. This suggests that some breeds might accumulate some heavy metals more than others, possibly due to genetic or environmental factors.

Conclusion and Implications

  • The findings of the study provide valuable insights into the concentrations of heavy metals in racehorses, especially in relation to certain types and locations of injuries.
  • This study may suggest a need for further research into the role of heavy metals in the health, performance and injury susceptibility of racehorses.
  • The difference in heavy metal concentrations across different ages and breeds of horses underscores the need for breed-specific and age-specific dietary and care considerations for racehorses.
  • However, more extensive research is required to fully understand the causal relationships and mechanisms linking heavy metal concentrations, breed, age, and injury type.

Cite This Article

APA
Plumlee KH, Johnson B, Gardner IA. (1996). Heavy metal concentrations in injured racehorses. Vet Hum Toxicol, 38(3), 204-206.

Publication

ISSN: 0145-6296
NlmUniqueID: 7704194
Country: United States
Language: English
Volume: 38
Issue: 3
Pages: 204-206

Researcher Affiliations

Plumlee, K H
  • California Veterinary Diagnostic Laboratory System, School of Veterinary Medicine, University of California, Davis 95616, USA.
Johnson, B
    Gardner, I A

      MeSH Terms

      • Aging / metabolism
      • Animals
      • Arsenic / analysis
      • Arsenic / metabolism
      • Bone and Bones / metabolism
      • Cadmium / analysis
      • Cadmium / metabolism
      • Copper / analysis
      • Copper / metabolism
      • Female
      • Fractures, Bone / metabolism
      • Fractures, Bone / mortality
      • Fractures, Bone / veterinary
      • Horses / injuries
      • Iron / analysis
      • Iron / metabolism
      • Kidney / metabolism
      • Lead / analysis
      • Lead / metabolism
      • Ligaments / injuries
      • Linear Models
      • Liver / metabolism
      • Male
      • Mass Spectrometry
      • Metals / metabolism
      • Molybdenum / analysis
      • Molybdenum / metabolism
      • Rupture / veterinary
      • Sex Factors
      • Tissue Distribution
      • Zinc / analysis
      • Zinc / metabolism

      Citations

      This article has been cited 4 times.
      1. Barrasso R, Ceci E, Stinga L, Tantillo G, Bozzo G. Presence of cadmium residues in muscle, liver and kidney of Bubalus bubalis and histological evidence. Ital J Food Saf 2018 Sep 26;7(3):7684.
        doi: 10.4081/ijfs.2018.7684pubmed: 30538963google scholar: lookup
      2. Passlack N, Mainzer B, Lahrssen-Wiederholt M, Schafft H, Palavinskas R, Breithaupt A, Zentek J. Concentrations of strontium, barium, cadmium, copper, zinc, manganese, chromium, antimony, selenium, and lead in the liver and kidneys of dogs according to age, gender, and the occurrence of chronic kidney disease. J Vet Sci 2015;16(1):57-66.
        doi: 10.4142/jvs.2015.16.1.57pubmed: 25234328google scholar: lookup
      3. Paßlack N, Mainzer B, Lahrssen-Wiederholt M, Schafft H, Palavinskas R, Breithaupt A, Neumann K, Zentek J. Concentrations of strontium, barium, cadmium, copper, zinc, manganese, chromium, antimony, selenium and lead in the equine liver and kidneys. Springerplus 2014;3:343.
        doi: 10.1186/2193-1801-3-343pubmed: 25061551google scholar: lookup
      4. Paßlack N, Mainzer B, Lahrssen-Wiederholt M, Schafft H, Palavinskas R, Breithaupt A, Zentek J. Liver and kidney concentrations of strontium, barium, cadmium, copper, zinc, manganese, chromium, antimony, selenium and lead in cats. BMC Vet Res 2014 Jul 17;10:163.
        doi: 10.1186/1746-6148-10-163pubmed: 25030305google scholar: lookup