Hendra and Nipah viruses: pathogenesis and therapeutics.
Abstract: Within the past decade a number of new zoonotic paramyxoviruses emerged from flying foxes to cause serious disease outbreaks in man and livestock. Hendra virus was the cause of fatal infections of horses and man in Australia in 1994, 1999 and 2004. Nipah virus caused encephalitis in humans both in Malaysia in 1998/99, following silent spread of the virus in the pig population, and in Bangladesh from 2001 to 2004 probably as a result of direct bat to human transmission and spread within the human population. Hendra and Nipah viruses are highly pathogenic in humans with case fatality rates of 40% to 70%. Their genetic constitution, virulence and wide host range make them unique paramyxoviruses and they have been given Biosecurity Level 4 status in a new genus Henipavirus within the family Paramyxoviridae. Recent studies on the virulence, host range and cell tropisms of henipaviruses provide insights into the unique biological properties of these emerging human pathogens and suggest approaches for vaccine development and therapeutic countermeasures.
Publication Date: 2005-12-27 PubMed ID: 16375714DOI: 10.2174/156652405774962308Google Scholar: Lookup
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The research article focuses on the pathogenesis and potential therapeutics for Hendra and Nipah viruses, identified as unique paramyxoviruses which emerged from flying foxes causing severe disease outbreaks in humans and livestock.
Overview of Hendra and Nipah Viruses
- The study begins by identifying Hendra and Nipah viruses as zoonotic paramyxoviruses that have emerged within the last ten years from flying foxes, also known as fruit bats.
- These viruses are known to cause severe disease outbreaks in humans and livestock. Hendra virus was identified in Australia as the cause of fatal infections in horses and humans in 1994, 1999, and 2004.
- Nipah virus, on the other hand, led to cases of encephalitis in humans in Malaysia from 1998 to 1999, linked to the context of the virus spreading in the pig population, and in Bangladesh from 2001 to 2004, likely due to direct bat to human transmission and also distribution within the human population.
Severity and Uniqueness of the Viruses
- Hendra and Nipah viruses are reported to be highly pathogenic in humans, with a case fatality rate between 40% and 70%. This high fatality rate affirms the severity and threat of these viruses.
- The genetic makeup, virulence, and wide host range of these pathogenic viruses distinguish them as unique paramyxoviruses, resulting in them being classified under Biosecurity Level 4 status in a new genus, named Henipavirus, within the family Paramyxoviridae.
Insights into the Behaviour of the Viruses
- Recent studies of these viruses provide valuable insights into their virulence, host range, and cell tropisms. This not only gives a clearer understanding of the biological properties that make these viruses unique but also offers critical information that aids in controlling and managing potential outbreaks in the future.
- Such insights could also indicate potential approaches for the development of a vaccine and possible therapeutic measures to combat these deadly viruses.
Cite This Article
APA
Eaton BT, Broder CC, Wang LF.
(2005).
Hendra and Nipah viruses: pathogenesis and therapeutics.
Curr Mol Med, 5(8), 805-816.
https://doi.org/10.2174/156652405774962308 Publication
Researcher Affiliations
- Australian Animal Health Laboratory, CSIRO, 5 Portarlington Road, Geelong, Victoria 3220, Australia. bryan.eaton@csiro.au
MeSH Terms
- Animals
- Antiviral Agents / therapeutic use
- Disease Models, Animal
- Drug Design
- Hendra Virus / classification
- Hendra Virus / pathogenicity
- Henipavirus Infections / epidemiology
- Henipavirus Infections / therapy
- Henipavirus Infections / virology
- Humans
- Nipah Virus / classification
- Nipah Virus / pathogenicity
- Viral Vaccines
- Virulence
References
This article includes 164 references
Citations
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