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Nutrients2021; 13(5); 1672; doi: 10.3390/nu13051672

Horse Placental Extract Enhances Neurogenesis in the Presence of Amyloid β.

Abstract: Human placental extract and animal-derived placental extracts from pigs and horses host a wide range of biological activities. Several placental products are used as medicines, cosmetics, and healthcare substances worldwide. However, the use of placental extracts for neuronal functioning is currently not established because the number of relevant studies is limited. A few previous reports suggested the neuroprotective effect and dendrite genesis effect of placental extract. However, no studies have reported on neurogenesis in placental extracts. Therefore, we aimed to investigate the effects of horse placental extract on neurogenesis, and we examined the protective effect of the extract on the onset of memory disorder. A horse placental extract, JBP-F-02, was used in this study. JBP-F-02 treatment dose-dependently increased the number of neural stem cells and dendrite length under Aβ treatment in primary cultured cortical cells. The oral administration of JBP-F-02 to a 5XFAD mouse model of Alzheimer's disease at a young age significantly prevented the onset of memory dysfunction. This study suggests that the extract has the potential to prevent dementia.
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Publication Date: 2021-05-14 PubMed ID: 34069207PubMed Central: PMC8157028DOI: 10.3390/nu13051672Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research focuses on the effects of horse placental extract on neurogenesis and its protective effect against memory disorders. The study indicates that treatment with horse placental extract increased the growth of neural stem cells and dendrites, particularly in conditions involving amyloid beta treatments, and showed potential in preventing dementia.

Understanding the Research

The research primarily focuses on:

  • Exploring the effect of placental extracts: The researchers aimed to investigate the effectiveness of horse placental extract (named JBP-F-02 in the study) on neurogenesis. Neurogenesis is the process of generating new neurons or nerve cells, an essential aspect of brain function.
  • Investigating the protective function of horse placental extract: Particularly, the study examined the extract’s ability to protect against memory disorders. This was tested using a mouse model of Alzheimer’s disease.

The Research Methods

  • The study used primary cultured cortical cells for experimentation: These cells were treated with Amyloid β (Aβ) – a peptide involved in Alzheimer’s disease, along with varying doses of the horse placental extract.
  • An Alzheimer’s mice model, 5XFAD, was used for a behavioral investigation: The mice were given an oral administration of the extract from a young age to observe if it prevented the onset of memory dysfunction.

    • Results and Implications

    • The horse placental extract JBP-F-02 was observed to increase the number of neural stem cells and the length of the dendrites (the branched extensions of nerve cells) in the cortical cells. Importantly, this increase was dose-dependent implying that greater concentrations of the extract corresponded to a higher increase in the stem cells and dendrites.
    • In the Alzheimer’s mice model, the administration of JBP-F-02 considerably prevented memory disorder progression. These results indicate the potential of the horse placental extract in managing Alzheimer’s disease and potentially other neurodegenerative diseases.

    To sum up, the study opens up new avenues in the use of placental extracts, particularly those derived from horses, in preventing memory disorders and enhancing neurogenesis. Given these promising results, further research can be expected in this domain.

Cite This Article

APA
de Toledo A, Nomoto K, Hirano E, Tohda C. (2021). Horse Placental Extract Enhances Neurogenesis in the Presence of Amyloid β. Nutrients, 13(5), 1672. https://doi.org/10.3390/nu13051672

Publication

Nutrients
ISSN: 2072-6643
NlmUniqueID: 101521595
Country: Switzerland
Language: English
Volume: 13
Issue: 5
PII: 1672

Researcher Affiliations

de Toledo, Andreia
  • Research Institute Japan Bio Products Co., Ltd. Kurume 839-0864, Japan.
Nomoto, Kaori
  • Research Institute Japan Bio Products Co., Ltd. Kurume 839-0864, Japan.
  • Section of Neuromedical Science, Division of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
Hirano, Eiichi
  • Research Institute Japan Bio Products Co., Ltd. Kurume 839-0864, Japan.
Tohda, Chihiro
  • Section of Neuromedical Science, Division of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.

MeSH Terms

  • Alzheimer Disease / drug therapy
  • Alzheimer Disease / prevention & control
  • Amyloid beta-Peptides / metabolism
  • Animals
  • Dendrites
  • Disease Models, Animal
  • Female
  • Horses
  • Memory Disorders / prevention & control
  • Mice
  • Mice, Transgenic
  • Neural Stem Cells / metabolism
  • Neurogenesis / drug effects
  • Neurons / metabolism
  • Neuroprotective Agents / therapeutic use
  • Placenta / metabolism
  • Placental Extracts / therapeutic use
  • Pregnancy
  • Swine

Grant Funding

  • the Japan Bio Products as a cooperative research project / Japan Bio Products

Conflict of Interest Statement

A.T. and E.H. are employees of Japan Bio Products.

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Citations

This article has been cited 4 times.
  1. Kotoku S, Tahara K, Hirano E. Successful steroid tapering and partial treatment of suspected immune-mediated haemolytic anaemia in a dog with equine placenta extract supplementation: A case report. Open Vet J 2023 May;13(5):668-676.
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  2. Amano T, Ikeda T, Yamaguchi M, Kakehi N, Hanada K, Watanabe T, Tahara K, Hirano E. Equine placental extract supplement as a night barking remedy in dogs with cognitive dysfunction syndrome. Vet Med Sci 2022 Sep;8(5):1887-1892.
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  3. Alimu Y, Yamamoto T, Nakahata Y. Biological effects of human placental extracts - variations in manufacturing methods and compositions. Front Pharmacol 2025;16:1707890.
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