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Hyperplastic goitre in newborn foals in Western Canada.

Abstract: Hyperplastic goitre was observed in seven newborn foals. Several were weak at birth and died in the first 48 hours of life. Only one foal had myxedema and only three of the seven had obvious enlargement of the thyroid at necropsy. It is suggested that the goitre observed was caused by a dietary deficiency of iodine.
Publication Date: 1981-02-01 PubMed ID: 7225996PubMed Central: PMC1789868
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research revolves around the observation of hyperplastic goitre in newborn foals in Western Canada. The study suggests that this condition may be due to a dietary deficiency of iodine.

About the Condition Observed

  • Hyperplastic goitre is a condition characterized by the enlargement of the thyroid gland and is observed in seven newborn foals in the study. This condition commonly occurs due to iodine deficiency, causing the thyroid to work harder to produce adequate amounts of thyroid hormones.
  • Some of the foals were weak at birth and died within the first two days of life, indicating the severity of health conditions these newborn foals were dealing with. This puts a spotlight on the importance of proper prenatal care and nutrient supply for the foals.

Detailed Observations

  • Not all foals showed prominent signs of the disease. Only one foal had myxedema – a condition resulting from the advanced stages of hypothyroidism characterized by skin and tissue swelling. This shows the varying degrees of disease manifestations in different individuals.
  • Similarly, only three of the seven foals showed apparent enlargement of the thyroid at necropsy, which is often the most noticeable sign of goitre. This implies that the disease can advance without significant visible changes, signaling the need for thorough and regular medical check-ups to monitor the condition of the newborn foals.

Possible Cause of Goitre

  • The study suggests that the goitre observed in foals might be caused by a dietary deficiency of iodine. Iodine is a crucial mineral required for the production of thyroid hormones. Its deficiency can lead to impaired thyroid function and eventually, conditions like goitre.
  • Given that the study is conducted in Western Canada, it could point towards potential iodine-deficient conditions in the region’s soil or pasture land affecting the horses’ diet – a point that needs further investigation for confirmation.

Cite This Article

APA
Doige CE, McLaughlin BG. (1981). Hyperplastic goitre in newborn foals in Western Canada. Can Vet J, 22(2), 42-45.

Publication

ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 22
Issue: 2
Pages: 42-45

Researcher Affiliations

Doige, C E
    McLaughlin, B G

      MeSH Terms

      • Animals
      • Animals, Newborn
      • Goiter / etiology
      • Goiter / pathology
      • Goiter / veterinary
      • Horse Diseases / etiology
      • Horse Diseases / pathology
      • Horses
      • Hyperplasia / pathology
      • Iodine / deficiency
      • Thyroid Gland / pathology

      References

      This article includes 7 references
      1. Baker HJ, Lindsey JR. Equine goiter due to excess dietary iodide.. J Am Vet Med Assoc 1968 Dec 15;153(12):1618-30.
        pubmed: 4177826
      2. Robbins J, Van Zyl A, Van der Walt K. Abnormal thyroglobin in congenital goiter of cattle.. Endocrinology 1966 Jun;78(6):1213-23.
        pubmed: 4958570doi: 10.1210/endo-78-6-1213google scholar: lookup
      3. Hopkins PS, Thorburn GD. The effects of foetal thyroidectomy on the development of the ovine foetus.. J Endocrinol 1972 Jul;54(1):55-66.
        pubmed: 5065283doi: 10.1677/joe.0.0540055google scholar: lookup
      4. Mason R, Wilkinson JS. The thyroid gland--a review.. Aust Vet J 1973 Jan;49(1):44-9.
      5. Wilson JG. Hypothyroidism in ruminants with special reference to foetal goitre.. Vet Rec 1975 Aug 30;97(9):161-4.
        pubmed: 1101518doi: 10.1136/vr.97.9.161google scholar: lookup
      6. Drew B, Barber WP, Williams DG. The effect of excess dietary iodine on pregnant mares and foals.. Vet Rec 1975 Aug 2;97(05):93-5.
        pubmed: 1154632doi: 10.1136/vr.97.5.93google scholar: lookup
      7. van Jaarsveld P, Theron C, van der Walt B, van Zyl A. Congenital goitre in South African boer goats.. J S Afr Vet Med Assoc 1971 Dec;42(4):295-303.
        pubmed: 5161414

      Citations

      This article has been cited 8 times.
      1. Ibrahim RS, El-Mezayen NS, Khairy A, Zaatout HH, Hammoda HM, Metwally AM. Biologically-Guided Isolation of Natural Lead Antithyroid Drug from Medicago sativa L. Sprouts and Its Toxic Profile in Comparison with Propylthiouracil.. J Food Drug Anal 2020 Sep 15;28(3):407-448.
        doi: 10.38212/2224-6614.1242pubmed: 35696097google scholar: lookup
      2. Yong CW, Griffin S. Saskatchewan. Goiter in foals on a pregnant mare urine farm.. Can Vet J 1992 Apr;33(4):276-7.
        pubmed: 17423992
      3. McLaughlin BG, Doige CE, McLaughlin PS. Thyroid hormone levels in foals with congenital musculoskeletal lesions.. Can Vet J 1986 Jul;27(7):264-7.
        pubmed: 17422675
      4. Niilo L, Chalmers GA. Hemorrhagic Enterotoxemia Caused by Clostridium perfringens Type C in a Foal.. Can Vet J 1982 Oct;23(10):299-301.
        pubmed: 17422190
      5. Allen AL, Townsend HG, Doige CE, Fretz PB. A case-control study of the congenital hypothyroidism and dysmaturity syndrome of foals.. Can Vet J 1996 Jun;37(6):349-51; 354-8.
        pubmed: 8689594
      6. Allen AL, Doige CE, Fretz PB, Townsend HG. Hyperplasia of the thyroid gland and concurrent musculoskeletal deformities in western Canadian foals: reexamination of a previously described syndrome.. Can Vet J 1994 Jan;35(1):31-8.
        pubmed: 8044756
      7. Allen AL. Hyperplasia of the thyroid gland and musculoskeletal deformities in two equine abortuses.. Can Vet J 1995 Apr;36(4):234-6.
        pubmed: 7600514
      8. McLaughlin BG, Doige CE. Congenital musculosketal lesions and hyperplastic goitre in foals.. Can Vet J 1981 May;22(5):130-3.
        pubmed: 7248888