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Journal of veterinary internal medicine1998; 11(6); 356-360; doi: 10.1111/j.1939-1676.1997.tb00480.x

Idiopathic hypocalcemia in foals.

Abstract: Five thoroughbred foals (4 fillies and 1 colt), all in good to excellent body condition, ranging in age from 4 days to 5 weeks at the time of onset of signs, were presented to 2 Kentucky equine hospitals from 1992 through 1996. All 5 foals presented with tachycardia, hyperhidrosis, diarrhea or a recent history of diarrhea, and muscle rigidity or stiff gait. Four of the 5 foals presented for recumbency, seizure-like activity with opisthotonos, or pronounced extensor muscle rigidity. All 5 foals were hypocalcemic. All foals either died or had euthanasia performed. None responded to oral calcium supplementation. The cause of the hypocalcemia was unknown. Different idiopathic hypocalcemia syndromes may exist in foals.
Publication Date: 1998-02-21 PubMed ID: 9470161DOI: 10.1111/j.1939-1676.1997.tb00480.xGoogle Scholar: Lookup
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Summary

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The research article describes a study on five young thoroughbred horses that all displayed symptoms of hypocalcemia, a condition where there are low calcium levels in the blood, despite being in good health. The cause of the condition remains unknown and all horses either died from it or were euthanized.

Study Subject

The research was conducted on five thoroughbred foals, which included four fillies and one colt. These foals were in good to excellent body condition and were between 4 days to 5 weeks old when the symptoms began.

  • The foals were presented to two Kentucky equine hospitals from 1992 to 1996.

Presenting Symptoms

Upon admission, all foals displayed similar symptoms:

  • All foals had tachycardia, a condition where the heart rate is excessively high.
  • Hyperhidrosis, or excessive sweating, was observed in all five foals.
  • Diarrhea or recent history of diarrhea was noted in all cases.
  • All foals exhibited muscle rigidity or a stiff gait.
  • Four out of five foals showed signs of recumbency, seizure-like activity with opisthotonos (a condition of extreme backward arching of the head, neck, and spine), or extreme muscle rigidity.

Finding: Hypocalcemia in Foals

After conducting clinical evaluations, all five foals were found to have hypocalcemia.

  • Hypocalcemia is a medical condition characterized by low levels of calcium in the blood.
  • All foals either eventually died or had to be euthanized due to the severity of the symptoms and the lack of treatment efficacy.
  • None of the foals responded to oral calcium supplementation, suggesting that the cause of hypocalcemia was not due to a simple lack of dietary calcium.

Conclusion

The study concluded that the cause of hypocalcemia in the examined foals was unknown, suggesting the possibility of different idiopathic (unknown cause) hypocalcemia syndromes in foals. Further research is needed to uncover the reason for this condition, how it can be treated effectively, and preventive measures.

Cite This Article

APA
Beyer MJ, Freestone JF, Reimer JM, Bernard WV, Rueve ER. (1998). Idiopathic hypocalcemia in foals. J Vet Intern Med, 11(6), 356-360. https://doi.org/10.1111/j.1939-1676.1997.tb00480.x

Publication

ISSN: 0891-6640
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 11
Issue: 6
Pages: 356-360

Researcher Affiliations

Beyer, M J
  • Hagyard-Davidson-McGee Associates, P.S.C., Lexington, KY, USA.
Freestone, J F
    Reimer, J M
      Bernard, W V
        Rueve, E R

          MeSH Terms

          • Animals
          • Animals, Newborn
          • Calcium / blood
          • Diarrhea / blood
          • Diarrhea / complications
          • Diarrhea / veterinary
          • Euthanasia
          • Fatal Outcome
          • Female
          • Horse Diseases
          • Horses
          • Hyperhidrosis / blood
          • Hyperhidrosis / complications
          • Hyperhidrosis / veterinary
          • Hypocalcemia / blood
          • Hypocalcemia / complications
          • Hypocalcemia / veterinary
          • Male
          • Parathyroid Hormone / blood
          • Phosphorus / blood
          • Tachycardia / blood
          • Tachycardia / complications
          • Tachycardia / veterinary

          Citations

          This article has been cited 4 times.
          1. Elcombe ME, Bellone RR, Magdesian KG, Finno CJ. Prevalence of the RAPGEF5 c.2624C>A and PLOD1 c.2032G>A variants associated with equine familial isolated hypoparathyroidism and fragile foal syndrome in the US Thoroughbred population (1988-2019). Equine Vet J 2023 Jul;55(4):666-671.
            doi: 10.1111/evj.13883pubmed: 36199159google scholar: lookup
          2. Rivas VN, Magdesian KG, Fagan S, Slovis NM, Luethy D, Javsicas LH, Caserto BG, Miller AD, Dahlgren AR, Peterson J, Hales EN, Peng S, Watson KD, Khokha MK, Finno CJ. A nonsense variant in Rap Guanine Nucleotide Exchange Factor 5 (RAPGEF5) is associated with equine familial isolated hypoparathyroidism in Thoroughbred foals. PLoS Genet 2020 Sep;16(9):e1009028.
            doi: 10.1371/journal.pgen.1009028pubmed: 32986719google scholar: lookup
          3. Corley KTT. Metabolic disorders in foals. Equine Vet Educ 2012 Aug;24(8):392-395.
          4. D'Angelo A, Bellino C, Bertone I, Cagnotti G, Iulini B, Miniscalco B, Casalone C, Gianella P, Cagnasso A. Seizure disorders in 43 cattle. J Vet Intern Med 2015 May-Jun;29(3):967-71.
            doi: 10.1111/jvim.12592pubmed: 25857732google scholar: lookup