Idiopathic hypocalcemia in foals.
- Case Reports
- Journal Article
Summary
The research article describes a study on five young thoroughbred horses that all displayed symptoms of hypocalcemia, a condition where there are low calcium levels in the blood, despite being in good health. The cause of the condition remains unknown and all horses either died from it or were euthanized.
Study Subject
The research was conducted on five thoroughbred foals, which included four fillies and one colt. These foals were in good to excellent body condition and were between 4 days to 5 weeks old when the symptoms began.
- The foals were presented to two Kentucky equine hospitals from 1992 to 1996.
Presenting Symptoms
Upon admission, all foals displayed similar symptoms:
- All foals had tachycardia, a condition where the heart rate is excessively high.
- Hyperhidrosis, or excessive sweating, was observed in all five foals.
- Diarrhea or recent history of diarrhea was noted in all cases.
- All foals exhibited muscle rigidity or a stiff gait.
- Four out of five foals showed signs of recumbency, seizure-like activity with opisthotonos (a condition of extreme backward arching of the head, neck, and spine), or extreme muscle rigidity.
Finding: Hypocalcemia in Foals
After conducting clinical evaluations, all five foals were found to have hypocalcemia.
- Hypocalcemia is a medical condition characterized by low levels of calcium in the blood.
- All foals either eventually died or had to be euthanized due to the severity of the symptoms and the lack of treatment efficacy.
- None of the foals responded to oral calcium supplementation, suggesting that the cause of hypocalcemia was not due to a simple lack of dietary calcium.
Conclusion
The study concluded that the cause of hypocalcemia in the examined foals was unknown, suggesting the possibility of different idiopathic (unknown cause) hypocalcemia syndromes in foals. Further research is needed to uncover the reason for this condition, how it can be treated effectively, and preventive measures.
Cite This Article
Publication
Researcher Affiliations
- Hagyard-Davidson-McGee Associates, P.S.C., Lexington, KY, USA.
MeSH Terms
- Animals
- Animals, Newborn
- Calcium / blood
- Diarrhea / blood
- Diarrhea / complications
- Diarrhea / veterinary
- Euthanasia
- Fatal Outcome
- Female
- Horse Diseases
- Horses
- Hyperhidrosis / blood
- Hyperhidrosis / complications
- Hyperhidrosis / veterinary
- Hypocalcemia / blood
- Hypocalcemia / complications
- Hypocalcemia / veterinary
- Male
- Parathyroid Hormone / blood
- Phosphorus / blood
- Tachycardia / blood
- Tachycardia / complications
- Tachycardia / veterinary
Citations
This article has been cited 4 times.- Elcombe ME, Bellone RR, Magdesian KG, Finno CJ. Prevalence of the RAPGEF5 c.2624C>A and PLOD1 c.2032G>A variants associated with equine familial isolated hypoparathyroidism and fragile foal syndrome in the US Thoroughbred population (1988-2019). Equine Vet J 2023 Jul;55(4):666-671.
- Rivas VN, Magdesian KG, Fagan S, Slovis NM, Luethy D, Javsicas LH, Caserto BG, Miller AD, Dahlgren AR, Peterson J, Hales EN, Peng S, Watson KD, Khokha MK, Finno CJ. A nonsense variant in Rap Guanine Nucleotide Exchange Factor 5 (RAPGEF5) is associated with equine familial isolated hypoparathyroidism in Thoroughbred foals. PLoS Genet 2020 Sep;16(9):e1009028.
- Corley KTT. Metabolic disorders in foals. Equine Vet Educ 2012 Aug;24(8):392-395.
- D'Angelo A, Bellino C, Bertone I, Cagnotti G, Iulini B, Miniscalco B, Casalone C, Gianella P, Cagnasso A. Seizure disorders in 43 cattle. J Vet Intern Med 2015 May-Jun;29(3):967-71.