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Animals : an open access journal from MDPI2022; 12(22); doi: 10.3390/ani12223125

Impact of Different Diagnostic Procedures on Diagnosis, Therapy, and Outcome in Horses with Headshaking: Recommendations for Fast-Track Advanced Diagnostic and Therapeutic Protocols.

Abstract: Most horses affected by headshaking (HS) are diagnosed with idiopathic trigeminal-mediated headshaking (i-TMHS) when no underlying disease is found. Diagnosis is made by the exclusion of differentials considering history, clinical signs, and diagnostic investigations. Therefore, in horses presented with headshaking, many diagnostic procedures and therapies are conducted. Retrospectively, the digital patient records of 240 horses with HS were analysed regarding the impact of diagnostic procedures on diagnosis, therapy, and outcome. Horses were extensively examined using a standardised protocol including clinical (ophthalmologic, orthopaedic, neurologic, dental) examination, blood analysis, and imaging techniques (endoscopy, radiographs, computed tomography (CT), and magnetic resonance imaging). Many findings were revealed but were of clinical relevance in only 6% of the horses. These horses were, therefore, diagnosed with secondary headshaking (s-HS). In addition, all of these horses demonstrated a positive outcome. The CT of the head revealed 9/10 of the clinically relevant findings. Other diagnostic procedures had no major additional impact. Conclusively, the diagnostic investigation of horses with HS should aim at differentiating i-TMHS from s-HS. The clinical relevance of findings should be verified through diagnostic anaesthesia or targeted therapy depending on risks, invasiveness, and expected benefits. To reduce the multitude of examinations, diagnostic investigations should focus on the CT of the head in those horses with suspicion of i-TMHS based on typical history, clinical signs, and physical examination.
Publication Date: 2022-11-13 PubMed ID: 36428354PubMed Central: PMC9686903DOI: 10.3390/ani12223125Google Scholar: Lookup
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  • Journal Article

Summary

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The research focuses on how using different diagnostic procedures affects the detection, treatment, and outcomes in horses suffering from a condition known as headshaking. It recommends adopting more efficient diagnostic and therapeutic practices, particularly the CT scan of the head, to identify if the animal is suffering from primary (idiopathic) or secondary headshaking.

Understanding Headshaking in Horses

  • This study revolves around a condition in horses known as headshaking (HS), where the dominant diagnosis is idiopathic trigeminal-mediated headshaking (i-TMHS) if no underlying disease is found.
  • The diagnosis of HS often has to rule out different factors by analyzing the horse’s history, presenting clinical signs, and conducting several medical investigations.
  • Therefore, horses showing symptoms of HS often undergo many diagnostic procedures and treatments.

Methodology: Retrospective Analysis of Patient Records

  • The research takes into account the digital records of 240 horses previously diagnosed with HS, studying the influence of various diagnostic procedures on diagnosis, therapy, and outcome.
  • The methodology included a standardized protocol of conducting a thorough examination of the horse, including ophthalmologic, orthopaedic, neurologic, and dental evaluations, blood work, and several imaging techniques such as endoscopy, radiographs, CT scans, and MRI.

Findings

  • In the course of the analysis, investigators discerned multiple findings, but only 6% of these were clinically relevant, leading these horses to be diagnosed with secondary headshaking (s-HS).
  • Horses diagnosed with s-HS showed positive outcomes after treatment.
  • Almost all clinically relevant findings (9 out of 10 cases) were observed via CT scans of the head, with other diagnostic measures having a far less significant impact.

Recommendations

  • The research suggests that diagnosing horses with HS should focus on distinguishing between i-TMHS and s-HS.
  • The clinical relevance of symptoms in the horses should be confirmed through diagnostic anaesthesia, or via targeted therapy depending upon the risk factors, invasiveness of the procedure, and expected benefits.
  • To reduce the burden of multiple examinations, investigations should primarily focus on performing CT scans of the head, especially for horses suspected of having i-TMHS based on their history, observed clinical signs, and physical examination.

Cite This Article

APA
Kloock T, Hellige M, Kloock A, Feige K, Niebuhr T. (2022). Impact of Different Diagnostic Procedures on Diagnosis, Therapy, and Outcome in Horses with Headshaking: Recommendations for Fast-Track Advanced Diagnostic and Therapeutic Protocols. Animals (Basel), 12(22). https://doi.org/10.3390/ani12223125

Publication

ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 12
Issue: 22

Researcher Affiliations

Kloock, Tanja
  • Clinic for Horses, University of Veterinary Medicine Hannover Foundation, Bünteweg 9, 30559 Hanover, Germany.
Hellige, Maren
  • Clinic for Horses, University of Veterinary Medicine Hannover Foundation, Bünteweg 9, 30559 Hanover, Germany.
Kloock, Anke
  • Department of Cell Biology, NYU Langone Medical Center, 550 First Avenue, New York, NY 10016, USA.
Feige, Karsten
  • Clinic for Horses, University of Veterinary Medicine Hannover Foundation, Bünteweg 9, 30559 Hanover, Germany.
Niebuhr, Tobias
  • Clinic for Horses, University of Veterinary Medicine Hannover Foundation, Bünteweg 9, 30559 Hanover, Germany.

Conflict of Interest Statement

The authors declare no conflict of interest.

References

This article includes 38 references
  1. Newton SA, Knottenbelt DC, Eldridge PR. Headshaking in Horses: Possible Aetiopathogenesis Suggested by the Results of Diagnostic Tests and Several Treatment Regimes Used in 20 Cases. Equine Vet. J. 2000;32:208–216.
    doi: 10.2746/042516400776563617pubmed: 10836475google scholar: lookup
  2. Madigan J, Bell S. Owner Survey of Headshaking in Horses. J. Am. Vet. Med. Assoc. 2001;219:334–337.
    doi: 10.2460/javma.2001.219.334pubmed: 11497047google scholar: lookup
  3. Roberts V. Managing Headshaking in Horses: An Update. Practice 2018;40:157–161.
    doi: 10.1136/inp.k1493google scholar: lookup
  4. Mills D, Cook S, Taylor K, Jones B. Analysis of the Variations in Clinical Signs Shown by 254 Cases of Equine Headshaking D. Vet. Rec. 2002;150:236–240.
    doi: 10.1136/vr.150.8.236pubmed: 11916024google scholar: lookup
  5. Aleman M, Williams DC, Brosnan RJ, Nieto JE, Pickles K, Berger J, Lecouteur RA, Holliday TA, Madigan J. Sensory Nerve Conduction and Somatosensory Evoked Potentials of the Trigeminal Nerve in Horses with Idiopathic Headshaking. J. Vet. Intern. Med. 2013;27:1571–1580.
    doi: 10.1111/jvim.12191pubmed: 24107198google scholar: lookup
  6. Aleman M, Rhodes D, Williams DC, Guedes A, Madigan J. Sensory Evoked Potentials of the Trigeminal Nerve for the Diagnosis of Idiopathic Headshaking in a Horse. J. Vet. Intern. Med. 2014;28:250–253.
    doi: 10.1111/jvim.12237pmc: PMC4895556pubmed: 24428325google scholar: lookup
  7. Pickles K, Aleman M, Cert MVZ, Marlin DJ, Adams VJ, Madigan J. Owner-Reported Response to Treatment of 130 Headshaking Horses. Am. Assoc. Equine Pract. 2014;60:176–183.
  8. Voigt A, Saulez MN, Donnellan CM. Nuchal Crest Avulsion Fracture in 2 Horses: A Cause of Headshaking. J. S. Afr. Vet. Assoc. 2009;80:111–113.
    doi: 10.4102/jsava.v80i2.183pubmed: 19831275google scholar: lookup
  9. Wimmer-Scherr CM, Evrard L, Amory H, Cesarini C. Ulcerative Lesion of the External Ear Canal Causing Headshaking in a Horse. Vet. Rec. Case Rep. 2019;7:1–4.
  10. Pickles K, Madigan J, Aleman M. Idiopathic Headshaking: Is It Still Idiopathic?. Vet. J. 2014;201:21–30.
    doi: 10.1016/j.tvjl.2014.03.031pubmed: 24821361google scholar: lookup
  11. Fiske-Jackson AR, Pollock PJ, Witte TH, Woolford L, Perkins JD. Fungal Sinusitis Resulting in Suspected Trigeminal Neuropathy as a Cause of Headshaking in Five Horses. Equine Vet. Educ. 2012;24:126–133.
  12. Kold SE, Østblom LC, Philipsen HP. Headshaking Caused by a Maxillary Osteoma in a Horse. Equine Vet. J. 1982;14:167–169.
  13. Mair TS. Headshaking Associated with Trombicula Autumnalis Larval Infestation in Two Horses. Equine Vet. J. 1994;26:244–245.
  14. McGorum BC, Dixon PM. Vasomotor Rhinitis with Headshaking in a Pony. Equine Vet. J. 1990;22:220–222.
  15. Moore LA, Johnson PJ, Messer NT, Kline KL, Crump LM, Knibb JR. Management of Headshaking in Three Horses by Treatment for Protozoal Myeloencephalitis. Vet. Rec. 1997;141:264–267.
    doi: 10.1136/vr.141.11.264pubmed: 9316239google scholar: lookup
  16. Schlichenmaier H. Headshaking Verursacht Durch Ein Osteom in Der Nasenhöhle Eines Pferdes. Pferdeheilkunde 2006;22:449–452.
  17. Stephenson R. An Unusual Case of Headshaking Caused by a Premaxillary Bone Cyst. Equine Vet. Educ. 2005;17:79–82.
  18. Lane G, Mair TS. Observations on Headshaking in the Horse. Equine Vet. J. 1987;19:331–336.
  19. Roberts V. Trigeminal-Mediated Headshaking in Horses: Prevalence, Impact, and Management Strategies. Vet. Med. Res. Rep. 2019;10:1–8.
    doi: 10.2147/VMRR.S163805pmc: PMC6330979pubmed: 30666296google scholar: lookup
  20. Mair TS, Lane G. Headshaking in Horses. Practice 1990;12:183–186.
    doi: 10.1136/inpract.12.5.183google scholar: lookup
  21. Kloock T, Niebuhr T, Feige K. Trigeminus-Mediiertes Headshaking—Von Der Diagnostik Bis Zur Therapie. Pferdespiegel 2021;24:52–57.
    doi: 10.1055/a-1467-1035google scholar: lookup
  22. Mills D, Cook S, Jones B. Reported Response to Treatment among 245 Cases of Equine Headshaking. Vet. Rec. 2002;150:311–313.
    doi: 10.1136/vr.150.10.311pubmed: 11913586google scholar: lookup
  23. Roberts V. Head Shaking in Horses: Causes, Pain Management and Treatment. Vet Times 2012.
  24. Stange LM, Krieter J, Czycholl I. Overview of the Current Situation in a Sample of Headshakers and Owner Assessment of Effective Therapeutic Measures Used in Germany. J. Equine Vet. Sci. 2020;95:103270.
    doi: 10.1016/j.jevs.2020.103270pubmed: 33276935google scholar: lookup
  25. Kruskal WH, Wallis A. Use of Ranks in One-Criterion Variance Analysis. J. Am. Stat. Assoc. 1952;47:583–621.
  26. Mann HB, Whitney DR. On a Test of Whether One of Two Random Variables Is Stochastically Larger than the Other. Ann. Math. Stat. 1947;18:50–60.
    doi: 10.1214/aoms/1177730491google scholar: lookup
  27. Pearson KX. On the Criterion That a given System of Deviations from the Probable in the Case of a Correlated System of Variables Is Such That It Can Be Reasonably Supposed to Have Arisen from Random Sampling. Lond. Edinb. Dublin Philos. Mag. J. Sci. 1900;50:157–175.
    doi: 10.1080/14786440009463897google scholar: lookup
  28. Slater J. Findings from the National Equine Health Survey 2013. Vet. Rec. 2014;11:271–272.
    doi: 10.1136/vr.g4982pubmed: 25234456google scholar: lookup
  29. Liuti T, Smith S, Dixon PM. Radiographic, Computed Tomographic, Gross Pathological and Histological Findings with Suspected Apical Infection in 32 Equine Maxillary Cheek Teeth (2012–2015). Equine Vet. J. 2018;50:41–47.
    doi: 10.1111/evj.12729pubmed: 28772346google scholar: lookup
  30. Kinns J, Pease A. Computed Tomography in the Evaluation of the Equine Head. Equine Vet. Educ. 2009;21:291–294.
    doi: 10.2746/095777309X423022google scholar: lookup
  31. Fairburn A, Meehan L, Roberts V. Computed tomographic findings in 101 horses presented for the investigation of headshaking. Equine Vet. Educ. 2022.
    doi: 10.1111/eve.13718google scholar: lookup
  32. Thomson K, Chan C, Dyson S. Head Tossing Behaviour in Six Horses: Trigeminal-Mediated Head-Shaking or Musculoskeletal Pain?. Equine Vet. Educ. 2020;32:58–64.
    doi: 10.1111/eve.13084google scholar: lookup
  33. Roberts V, Perkins JD, Skärlina E, Gorvy DA, Tremaine WH, Williams A, Mckane SA. Caudal Anaesthesia of the Infraorbital Nerve for Diagnosis of Idiopathic Headshaking and Caudal Compression of the Infraorbital Nerve for Its Treatment, in 58 Horses. Equine Vet. J. 2012;45:107–110.
  34. Wilmink S, Warren-Smith CMR, Roberts V. Validation of the Accuracy of Needle Placement as Used in Diagnostic Local Analgesia of the Maxillary Nerve for Investigation of Trigeminally Mediated Headshaking in Horses. Vet. Rec. 2015;176:148.
    doi: 10.1136/vr.102518pubmed: 25433055google scholar: lookup
  35. Kloock T, Roberts V, Pickles K, Uhlendorf F, Twele L, Wilkens H, Stehle E, Niebuhr T, Feige K. History Rest and Exercise Score (HRE-S) for Assessment of Disease Severity in Horses with Trigeminal-Mediated Headshaking. Equine Vet. J. 2022. submitted.
    pubmed: 37608443
  36. Talbot WA, Pinchbeck GL, Knottenbelt DC, Graham H, McKane SA. A Randomised, Blinded, Crossover Study to Assess the Efficacy of a Feed Supplement in Alleviating the Clinical Signs of Headshaking in 32 Horses. Equine Vet. J. 2013;45:293–297.
  37. Ross SE, Murray JK, Roberts V. Prevalence of Headshaking within the Equine Population in the UK. Equine Vet. J. 2018;50:73–78.
    doi: 10.1111/evj.12708pubmed: 28608565google scholar: lookup
  38. Madigan J, Bell S. Evaluation and Treatment of Headshaking Syndrome. Am. Assoc. Equine Pract. 1997;43:340–342.