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Home / Equine Research Bank / Animals (Basel) / Impaired Reproductive Function in Equines: From Genetics to ...
Animals : an open access journal from MDPI2021; 11(2); 393; doi: 10.3390/ani11020393

Impaired Reproductive Function in Equines: From Genetics to Genomics.

Abstract: Fertility is one of the key factors in the economic and productive success of the equine industry. Despite this, studies on the genetic causes affecting reproductive performance are scarce, especially in mares, where the genetic architecture of the reproductive traits is extremely complex. Today, with the increasing availability of new genomic methodologies for this species, we are presented with an interesting opportunity to understand the genetic basis of equine reproductive disorders. These include, among others, novel techniques for detecting chromosomal abnormalities, whose association with infertility in horses was established over 50 years ago; new sequencing technologies permitting an accurate detection of point mutations influencing fertility, as well as the study of inbreeding and molecular homozygosity, which has been widely suggested as one of the main causes of low reproductive performance in horses. Finally, over the last few years, reproductive performance has also been associated with copy number variants and candidate genes detected by genome-wide association studies on fertility traits. However, such studies are still scarce, probably because they depend on the existence of large and accurate phenotypic datasets of reproductive and/or fertility traits, which are still difficult to obtain in equines.
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Publication Date: 2021-02-03 PubMed ID: 33546520PubMed Central: PMC7913728DOI: 10.3390/ani11020393Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article investigates the role of genetic factors in the reproductive performance of horses. With the enhanced genomic methodologies available today, the article emphasizes the potential to further understand the genetic basis of equine reproductive disorders including chromosomal abnormalities, point mutations, the impact of inbreeding and the role of copy number variants.

Understanding Equine Reproductive Disorders

  • The researchers in this paper explore how genomic methodologies can be used to understand the genetic underpinnings of reproductive function in horses.
  • Despite the economic and productive importance of horse fertility, the genetic dynamics that affect equine reproductive performance are poorly understood – an issue that is particularly acute in mares, where the genetic architecture of reproductive traits is incredibly complex.
  • The research calls attention to several reproductive disorders in horses that can be investigated using genomic methodologies, including chromosomal abnormalities, the presence of point mutations, and patterns of inbreeding and molecular homozygosity.

Genomic Methodologies at the Forefront

  • The article discusses an interesting opportunity presented by the increased availability of new genomic methodologies for horses.
  • These novel techniques allow for the detection of chromosomal abnormalities, which have been linked to infertility in horses for over 50 years.
  • Moreover, new sequencing technologies also allow for precise detection of point mutations that affect fertility.

Evidence of Genetic Influence on Horse Fertility

  • The review also mentions the study of inbreeding and molecular homozygosity, which has been suggested as one of the main causes of low reproductive performance in horses.
  • The researchers also noted that reproductive performance has been linked with variabilities in gene copy numbers. These variabilities, known as copy number variants, and candidate genes have been discovered by genome-wide association studies focusing on fertility traits.
  • However, these types of studies are still few and far between, in large part because they rely on the availability of large, accurate datasets of reproductive and fertility traits, which are difficult to collect in the case of horses.

Cite This Article

APA
Laseca N, Anaya G, Peña Z, Pirosanto Y, Molina A, Demyda Peyrás S. (2021). Impaired Reproductive Function in Equines: From Genetics to Genomics. Animals (Basel), 11(2), 393. https://doi.org/10.3390/ani11020393

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 11
Issue: 2
PII: 393

Researcher Affiliations

Laseca, Nora
  • Departamento de genética, Universidad de Córdoba, Campus de Rabanales Ctra, Madrid-Cádiz, km 396, 14071 Córdoba, Spain.
Anaya, Gabriel
  • Departamento de genética, Universidad de Córdoba, Campus de Rabanales Ctra, Madrid-Cádiz, km 396, 14071 Córdoba, Spain.
Peña, Zahira
  • Departamento de genética, Universidad de Córdoba, Campus de Rabanales Ctra, Madrid-Cádiz, km 396, 14071 Córdoba, Spain.
Pirosanto, Yamila
  • Departamento de Producción Animal, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata 1900, Argentina.
  • Consejo Superior de Investigaciones Científicas y Tecnológicas (CONICET), CCT-La Plata, La Plata 1900, Argentina.
Molina, Antonio
  • Departamento de genética, Universidad de Córdoba, Campus de Rabanales Ctra, Madrid-Cádiz, km 396, 14071 Córdoba, Spain.
Demyda Peyrás, Sebastián
  • Departamento de Producción Animal, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata 1900, Argentina.
  • Consejo Superior de Investigaciones Científicas y Tecnológicas (CONICET), CCT-La Plata, La Plata 1900, Argentina.

Grant Funding

  • PICT2016-0359 / Agencia Nacional de Promociu00f3n Cientu00edfica y Tecnolu00f3gica
  • PICT2018-0227 / Agencia Nacional de Promociu00f3n Cientu00edfica y Tecnolu00f3gica
  • AGL-2017-84217-P / Ministerio de Economu00eda, Industria y Competitividad, Gobierno de Espau00f1a
  • PRE 2018-083492 / Ministerio de Economu00eda, Industria y Competitividad, Gobierno de Espau00f1a

Conflict of Interest Statement

The authors declare no conflict of interest.

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