Increased serum nonesterified fatty acid and low ionised calcium concentrations are associated with post partum colic in mares.

The research article reveals a correlation between increased levels of nonesterified fatty acids (NEFA) and reduced ionised calcium (iCa) in the blood of mares after giving birth (post-partum), with an increased incidence of colic, a common digestive disorder in horses.

Research Purpose and Methodology

• The main goal of this research was to investigate the possible association between fluctuations in the serum levels of NEFA, iCa, and ionised magnesium (iMg) in mares after birth and the occurrence of post-partum colic. It expands the exploration of potential metabolic changes during pregnancy and postpartum periods, which are suspected to impact the development of this condition.
• The researchers conducted a thorough longitudinal observational investigation using mares from three distinct farms located in central Kentucky.
• Mares’ blood samples were collected at four different stages: 14 days before the estimated foaling date, within the first four days after parturition, as well as 14 and 28 days after foaling. These samples were then analyzed for serum NEFA, iCa, and iMg levels.
• To assess the health of the mares, researchers relied on health information provided by the farm managers and veterinarians. They used statistical methods to analyze the data, including Kruskal-Wallis χ(2) for nonparametric data evaluation and a matched case/control approach. They also utilized repeated measures logistic regression models.

Findings and Conclusion

• The research found that serum NEFAs were significantly higher just before, and in the first four days after foaling, in mares that developed colic as compared to ones that did not.
• The levels of ionised calcium were lower two to four weeks after foaling in mares that exhibited colic symptoms, compared to mares that did not. In specific, for every increase of 0.1 mmol/l in serum NEFA, the risk of colic in postpartum mares rose by 38%.
• The study concludes that mares with postpartum colic had notably higher NEFA and lower iCa levels in the serum ahead of the colic episode when compared to mares that did not develop colic. These findings indicate that these metabolic changes can be monitored to potentially predict and prevent colic in mares after giving birth.