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The Canadian veterinary journal = La revue veterinaire canadienne2021; 62(11); 1190-1194;

Inflammatory bowel disease characterized by multisystemic eosinophilic epitheliotropic disease (MEED) in a horse in Saskatchewan, Canada.

Villagru00e1n, CC
·
Vogt, D
·
Gupta, A
·
Fernu00e1ndez, EA

Abstract: A 3-year-old Quarter Horse gelding was evaluated for chronic weight loss, diarrhea, and pruritus. Physical examination revealed several ulcerative lesions on the skin and mucosal membranes. Diagnostic imaging findings were consistent with enteritis, typhlitis, and colitis. Multisystemic eosinophilic epitheliotropic disease (MEED) was diagnosed upon necropsy. This disease may be considered a form of equine inflammatory bowel disease complex which can be challenging to diagnose, requiring histological assessment, and in some cases, the use of immunohistochemical markers. Key clinical message: Multisystemic eosinophilic epitheliotropic disease is challenging to diagnose but should be considered in horses with chronic weight loss that fail to respond to conventional treatment for concurrent diarrhea and skin lesions. Un hongre Quarter Horse âgé de 3 ans a été présenté pour perte de poids chronique, diarrhée et prurit. L’examen clinique a révélé des lésions ulcératives de la peau et des muqueuses buccales. Les résultats d’imageries ont mis en évidence des lésions correspondant à celles vue lors d’entérite, typhlite et colite. La maladie épithéliotrope multisystémique éosinophilique (MEME) fut diagnostiquée par nécropsie. La MEME peut être considéré comme une forme de la maladie inflammatoire intestinal des chevaux, qui peut être difficile à diagnostiquer, nécessite une évaluation histologique, et parfois l’utilisation de marqueurs immunohistochimiques.Message clinique clé :La MEME est difficile à diagnostiquer mais devrait être envisagée chez les chevaux souffrant d’une perte de poids chronique qui ne répondent plus à la thérapie conventionnelle de la diarrhée et des lésions cutanées concomitantes.(Traduit par D Claudia Cruz Villagrán).

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Publication Date: 2021-11-04 PubMed ID: 34728845PubMed Central: PMC8543654

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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article discusses the diagnosis of a unique equine inflammatory bowel disease, Multisystemic eosinophilic epitheliotropic disease (MEED), in a Quarter Horse, presenting chronic weight loss, diarrhea, and skin lesions. The study emphasizes that MEED, although challenging to identify, should be considered when horses fail to respond to usual treatments.

Overview of the Study

The focus of this study is a 3-year-old Quarter Horse gelding which was brought in for evaluation due to chronic weight loss, diarrhea, and pruritus (intense itching).
An initial physical examination identified multiple ulcerative lesions on the animal’s skin and within its mucosal membranes.

Investigations and Findings

Using diagnostic imaging, the research team found indications of enteritis (inflammation of the small intestine), typhlitis (inflammation of the cecum), and colitis (inflammation of the colon).
Upon performing a necropsy (post-mortem examination), the team diagnosed the horse with Multisystemic eosinophilic epitheliotropic disease (MEED), a rare and complex form of equine inflammatory bowel disease.

Implications of the Study

The researchers suggest that due to the complexity of the condition, MEED can be quite challenging to diagnose, often requiring histological assessment (study of the microscopic structure of tissues) and, in some instances, the use of immunohistochemical markers (the use of antibodies to detect specific proteins in cells of a tissue section).
This study emphasizes that MEED should be taken into consideration when treating horses with chronic weight loss that do not respond to standard treatments for accompanying diarrhea and skin lesions.

Conclusion

The paper concludes with the importance of recognizing rare inflammatory bowel diseases, such as MEED, in horses, especially when other traditional treatments fail to produce improvements.

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APA

Villagru00e1n CC, Vogt D, Gupta A, Fernu00e1ndez EA. (2021). Inflammatory bowel disease characterized by multisystemic eosinophilic epitheliotropic disease (MEED) in a horse in Saskatchewan, Canada. Can Vet J, 62(11), 1190-1194.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne

ISSN: 0008-5286

NlmUniqueID: 0004653

Country: Canada

Language: English

Volume: 62

Issue: 11

Pages: 1190-1194

Researcher Affiliations

Villagru00e1n, Claudia Cruz

Department of Large Animal Clinical Sciences (Cruz Villagru00e1n, Vogt) and Department of Veterinary Pathology (Gupta, Aburto), Western College of Veterinary Medicine, The University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.

Vogt, Debora

Department of Large Animal Clinical Sciences (Cruz Villagru00e1n, Vogt) and Department of Veterinary Pathology (Gupta, Aburto), Western College of Veterinary Medicine, The University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.

Gupta, Ashish

Department of Large Animal Clinical Sciences (Cruz Villagru00e1n, Vogt) and Department of Veterinary Pathology (Gupta, Aburto), Western College of Veterinary Medicine, The University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.

Fernu00e1ndez, Enrique Aburto

Department of Large Animal Clinical Sciences (Cruz Villagru00e1n, Vogt) and Department of Veterinary Pathology (Gupta, Aburto), Western College of Veterinary Medicine, The University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.

MeSH Terms

Animals
Colitis / veterinary
Horse Diseases / diagnosis
Horses
Inflammatory Bowel Diseases / diagnosis
Inflammatory Bowel Diseases / veterinary
Male
Saskatchewan / epidemiology
Skin Diseases / veterinary

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