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Animals : an open access journal from MDPI2022; 12(6); 778; doi: 10.3390/ani12060778

Inflammatory Response and Electrocardiographic Examination in Horses Vaccinated against Equine Herpesvirus (Ehv-1).

Abstract: This study aimed to evaluate possible abnormalities in electrocardiographic findings, and changes in cardiac troponin I (cTnI) and inflammatory biomarkers (serum amyloid A (SAA) and C-reactive protein (CRP)) after inactivated herpesvirus vaccine administration. Eighteen healthy horses were included. All animals were vaccinated with Pneumoequine (Merial, France) according to the protocol provided by the manufacturer. They were evaluated 1 day before the first dose of vaccination (D0), and 7 days (D1) and 14 days (D2) afterwards. At D0, D1, and D2, a blood sample was taken for the evaluation of SAA, cTnI, and CRP. An electrocardiographic examination was also performed. The data obtained suggested the possible involvement of the myocardium following vaccination against herpesvirus 1, mostly related to an inflammatory response.
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Publication Date: 2022-03-19 PubMed ID: 35327175PubMed Central: PMC8944655DOI: 10.3390/ani12060778Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research examines the potential impact of equine herpesvirus vaccination (Ehv-1) on a horse’s heart, particularly looking at heart abnormalities and changes in certain biomarkers linked with inflammation. The study involved 18 healthy horses who were administered Pneumoequine vaccine and tested for abnormal electrocardiographic findings, and changes in cardiac troponin I (cTnI) and inflammatory biomarkers at different timings.

Study Methodology

  • The study encompassed 18 healthy horses, all of which were vaccinated with Pneumoequine, an inactivated herpesvirus vaccine.
  • Horses were evaluated one day before the first vaccine dose (D0), seven days after (D1), and again fourteen days afterwards (D2).
  • At each of these times, blood samples were collected with the aim of evaluating the levels of serum amyloid A (SAA), cTnI, and CRP.
  • Alongside these tests, an electrocardiographic examination was performed on each horse to assess possible heart irregularities.

Research Findings

  • The data collected from these tests was analyzed, and researchers identified potential signs of myocardium involvement following the administration of the herpesvirus 1 vaccine.
  • The myocardium refers to the heart muscle tissue that contracts to pump blood out of the heart and then relaxes as the heart refills with returning blood. Any involvement or impact on this tissue following vaccination indicates a possible alteration in the horse’s heart functioning as a result of the vaccine.
  • This impact was found to be likely related to an inflammatory response, as suggested by the changes observed in the inflammatory biomarkers SAA and CRP following vaccination.

Implications of the Research

  • The findings of this research raise potential concerns about the cardiac effects of the equine herpesvirus vaccination, implying further research is necessary to better understand these effects and develop strategies for their management or prevention.
  • Veterinary professionals might need to monitor horses more closely following administration of the herpesvirus vaccine, focusing on cardiac health and any signs of inflammation.

Cite This Article

APA
Biondi V, Landi A, Pugliese M, Merola G, Passantino A. (2022). Inflammatory Response and Electrocardiographic Examination in Horses Vaccinated against Equine Herpesvirus (Ehv-1). Animals (Basel), 12(6), 778. https://doi.org/10.3390/ani12060778

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 12
Issue: 6
PII: 778

Researcher Affiliations

Biondi, Vito
  • Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
Landi, Alessandra
  • Veterinary Practitioner, 98168 Messina, Italy.
Pugliese, Michela
  • Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
Merola, Giordana
  • Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
Passantino, Annamaria
  • Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.

Conflict of Interest Statement

The authors declare no conflict of interest.

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Citations

This article has been cited 3 times.
  1. Alpysbayeva SE, Abdykalyk AA, Tileukhanov K, Abdimukhtar AR, Toleukhan AT, Sarmykova MK, Anarbekova AM, Shayakhmetov YA, Syrym NS, Nurabaev SS, Yespembetov BA. Evaluating the Biochemical and Haematological Safety of the Histoplasma capsulatum var. farciminosum '8ZH' Vaccine in Foals. Vet Med Sci 2026 Jan;12(1):e70764.
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  2. Foreman JH, Tennent-Brown BS, Oyama MA, Sisson DD. Plasma Cardiac Troponin-I Concentration in Normal Horses and in Horses with Cardiac Abnormalities. Animals (Basel) 2025 Jan 3;15(1).
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  3. Kälin D, Becsek A, Stürmer H, Bachofen C, Siegrist D, Jonsdottir HR, Schoster A. Immune Response after Vaccination against Tick-Borne Encephalitis Virus (TBEV) in Horses. Vaccines (Basel) 2024 Sep 19;12(9).
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