Biological trace element research2022; 201(4); 1695-1703; doi: 10.1007/s12011-022-03270-y

Influence of Dietary Selenium on the Oxidative Stress in Horses.

Abstract: The objective of this review was to analyze the effect of dietary selenium on oxidative stress in horses by considering past and recent bibliographic sources. Some research was done on oxidative stress, related pathologies and how selenium regulates oxidative stress. Oxidizing molecules are molecules that can accept electrons from the substances with which they react. Oxidizing These molecules, of oxidizing, are found naturally in any organism, and there are antioxidant mechanisms that regulate its activity. However, when the body is stressed, oxidizing molecules outperform the antioxidants, causing an imbalance known as oxidative stress. Among antioxidant molecules, selenium can act as an important antioxidant in the body. The antioxidant activity is based on an enzyme called glutathione peroxidase, which depends on selenium and controls the activity of oxidizing molecules.
Publication Date: 2022-05-08 PubMed ID: 35526205PubMed Central: 4298223DOI: 10.1007/s12011-022-03270-yGoogle Scholar: Lookup
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The research article deals with the analysis of how dietary selenium influences oxidative stress in horses. Through a comprehensive study of past and current references, it discusses the role of selenium in regulating oxidizing molecules and how it contributes to antioxidant activities.

Understanding oxidative stress and selenium’s role

  • The review begins by shedding light on the concept of oxidative stress. This state of imbalance arises in an organism when oxidizing molecules, which inherently accept electrons from other substances during a reaction, outnumber the body’s antioxidant mechanisms.
  • These oxidizing molecules naturally present in any organism are kept in check by various antioxidant mechanisms.
  • However, during periods of stress, the quantity of these molecules surpasses the antioxidants, leading to a state known as oxidative stress.
  • The research emphasizes the role of selenium, a compound that can function as a significant antioxidant in the body. Its antioxidative property relies on an enzyme termed glutathione peroxidase.
  • This enzyme, which depends on selenium for functioning, effectively regulates the activity of oxidizing molecules and helps to maintain a balance in the body.

Selenium and related pathologies

  • The research additionally investigates the connection between oxidative stress and related pathologies. An intense focus is laid on the correlation between selenium and these ailments.
  • The research investigates whether an increase or decrease in selenium input in the horse’s diet might influence their antioxidant capacities and, consequently, lead to diseases related to oxidative stress.

Implications of the findings

  • The findings of this research are potentially beneficial for equine health management. An understanding of the influence of dietary selenium levels on the oxidative stress in horses can provide valuable insights that may help in forming better dietary plans for horses, thereby improving their overall health and well-being.
  • This understanding could also support and enhance effective treatment strategies for diseases related to oxidative stress.

Cite This Article

Culhuac EB, Elghandour MMMY, Adegbeye MJ, Barbabosa-Pliego A, Salem AZM. (2022). Influence of Dietary Selenium on the Oxidative Stress in Horses. Biol Trace Elem Res, 201(4), 1695-1703.


ISSN: 1559-0720
NlmUniqueID: 7911509
Country: United States
Language: English
Volume: 201
Issue: 4
Pages: 1695-1703

Researcher Affiliations

Culhuac, Erick Bahena
  • Facultad de Ciencias, Universidad Autu00f3noma del Estado de Mu00e9xico, Toluca, Estado de Mu00e9xico, Mu00e9xico.
Elghandour, Mona M M Y
  • Facultad de Medicina Veterinaria Y Zootecnia, Universidad Autu00f3noma del Estado de Mu00e9xico, Toluca, Estado de Mu00e9xico, Mu00e9xico.
Adegbeye, Moyosore J
  • Department of Animal Production and Health, Federal University of Technology, Akure, P.M.B. 704, Nigeria.
Barbabosa-Pliego, Alberto
  • Facultad de Medicina Veterinaria Y Zootecnia, Universidad Autu00f3noma del Estado de Mu00e9xico, Toluca, Estado de Mu00e9xico, Mu00e9xico.
Salem, Abdelfattah Z M
  • Facultad de Medicina Veterinaria Y Zootecnia, Universidad Autu00f3noma del Estado de Mu00e9xico, Toluca, Estado de Mu00e9xico, Mu00e9xico.

MeSH Terms

  • Horses
  • Animals
  • Antioxidants / metabolism
  • Selenium / pharmacology
  • Oxidative Stress
  • Glutathione Peroxidase / metabolism


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