Oxidative stress, osmotic stress and apoptosis: impacts on sperm function and preservation in the horse.

Ball, BA

Abstract: Oxidative stress is an important component of the cytopathology of equine spermatozoa undergoing storage as liquid or frozen semen. Damage to chromatin, membranes and proteins of sperm are important components of oxidative damage to sperm. Similarly, sperm are exposed to a variety of osmotic stresses during storage that result from exposure to hypertonic media or result as a consequence of osmotic changes induced during freezing. A number of changes induced during processing and storage of equine sperm also appear to induce apoptotic-like changes which may adversely affect sperm survival and function. These processes appear in many cases to be interrelated, and this review will examine current understanding of these processes on the equine sperm function.

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Publication Date: 2008-04-29 PubMed ID: 18524506DOI: 10.1016/j.anireprosci.2008.04.014Google Scholar: Lookup

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This research article investigates the impact of oxidative stress, osmotic stress, and apoptosis on the preservation and functionality of horse sperm during storage.

Oxidative stress and its impacts

Oxidative stress refers to an imbalance between the production of harmful reactive oxygen species (ROS) and the body’s ability to promptly detoxify these components.
In the context of equine spermatozoa, oxidative stress becomes prominent during the storage of semen, which can be in liquid or frozen form. This stress damages various components of the sperm, including the chromatin, membranes, and proteins.
Oxidative damage in sperm can result in decreased fertility due to damage to the genetic material in sperm.

Osmotic stress and its impacts

Osmotic stress happens when sperm are exposed to a range of osmotic challenges during storage, stemming from exposure to hypertonic media – a term used to describe solutions with higher concentrations of solute compared to others – or as a consequence of modifications in osmotic balance during freezing.
This stress can have a detrimental effect on the structural integrity and functionality of the sperm cells.

Apoptosis-like changes

Apoptosis is a controlled form of cell death that is crucial to normal development and homeostasis. However, during the processing and storage of equine sperm, various changes can induce apoptosis-like alterations.
Such changes can negatively influence sperm survival and, consequently, their capability to fertilize the egg.

Interrelation of the processes

The authors of the study highlight that in many cases, oxidative stress, osmotic stress, and apoptosis-like changes in equine sperm during storage appear to be linked, forming a complex interplay that influences the viability of the sperm cells.
The study aims to provide an understanding of these interconnected processes and their effects on equine sperm function, possibly leading to new methods for preserving and improving the usability of stored equine sperm.

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APA

Ball BA. (2008). Oxidative stress, osmotic stress and apoptosis: impacts on sperm function and preservation in the horse. Anim Reprod Sci, 107(3-4), 257-267. https://doi.org/10.1016/j.anireprosci.2008.04.014

Publication

Animal reproduction science

ISSN: 0378-4320

NlmUniqueID: 7807205

Country: Netherlands

Language: English

Volume: 107

Issue: 3-4

Pages: 257-267

Researcher Affiliations

Ball, Barry A

Department of Population Health and Reproduction, University of California, Davis, CA 95616, USA. baball@ucdavis.edu

MeSH Terms

Animals
Apoptosis / physiology
Horses / physiology
Male
Osmotic Pressure
Oxidative Stress / physiology
Semen Preservation / adverse effects
Spermatozoa / pathology
Spermatozoa / physiology

Citations

This article has been cited 38 times.

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