Inhaled anesthetics in horses.
Abstract: Inhaled agents represent an important and useful class of drugs for equine anesthesia. This article reviews the ether-type anesthetics in contemporary use, their uptake and elimination, their mechanisms of action, and their desirable and undesirable effects in horses.
Copyright © 2013 Elsevier Inc. All rights reserved.
Publication Date: 2013-01-18 PubMed ID: 23498046PubMed Central: PMC3601575DOI: 10.1016/j.cveq.2012.11.006Google Scholar: Lookup
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Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article focuses on the use of inhaled anesthetics in equine anesthesia. It reviews the types currently being used, how they are consumed and eliminated by the horse’s body, how they work, as well as their pros and cons.
Anesthetic Types in Use
- The study first discusses the various kinds of ether-type anesthetics that are currently in use for equine anesthesia. These are a specific category of anesthetic agents that are inhaled and are typically very effective for inducing and maintaining a state of unconsciousness in horses during surgical procedures.
Uptake and Elimination
- Next, the research addresses how these anesthetic agents are taken up and eliminated by the horse’s body. Uptake refers to how the anesthetics are absorbed into the bloodstream after inhalation. Elimination then involves how these agents are eventually removed from the body, typically through metabolic processes and excretion.
Mechanism of Action
- The study delves into the working mechanisms of these anesthetics. Often, these agents work by inhibiting certain neurotransmitters in the brain which are responsible for sensation and consciousness. This results in the horse becoming unconscious and insensitive to pain, which is crucial during surgical procedures.
Desirable and Undesirable Effects
- Lastly, the research paper looks at the positive and negative effects of using these types of anesthetics on horses. Desirable effects might include swift induction of anesthesia, stable maintenance of unconsciousness, and manageable recovery phases. Meanwhile, undesirable effects could range from minor symptoms like nausea to more serious side effects like respiratory depression and cardiovascular instability.
Cite This Article
APA
Brosnan RJ.
(2013).
Inhaled anesthetics in horses.
Vet Clin North Am Equine Pract, 29(1), 69-87.
https://doi.org/10.1016/j.cveq.2012.11.006 Publication
Researcher Affiliations
- Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA. rjbrosnan@ucdavis.edu
MeSH Terms
- Anesthesia, Inhalation / adverse effects
- Anesthesia, Inhalation / methods
- Anesthesia, Inhalation / veterinary
- Anesthetics, Inhalation / administration & dosage
- Anesthetics, Inhalation / adverse effects
- Anesthetics, Inhalation / pharmacokinetics
- Animals
- Blood Gas Analysis / veterinary
- Dose-Response Relationship, Drug
- Horses / physiology
Grant Funding
- R01 GM092821 / NIGMS NIH HHS
- GM092821-02 / NIGMS NIH HHS
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Citations
This article has been cited 5 times.- Rabbogliatti V, Amari M, Brioschi FA, Di Cesare F, Zani DD, De Zani D, Di Giancamillo M, Cagnardi P, Ravasio G. Use of dexmedetomidine repeated subcutaneous administration for balanced anaesthesia in horses.. BMC Vet Res 2022 Jul 11;18(1):269.
- Stefanik E, Drewnowska O, Lisowska B, Turek B. Causes, Effects and Methods of Monitoring Gas Exchange Disturbances during Equine General Anaesthesia.. Animals (Basel) 2021 Jul 9;11(7).
- Cerullo M, Driessen B, Douglas H, Hopster K. Changes in Arterial Blood Pressure and Oxygen Tension as a Result of Hoisting in Isoflurane Anesthetized Healthy Adult Horses.. Front Vet Sci 2020;7:601326.
- Brosnan RJ, Fukushima FB, Pham TL. Anesthetic synergy between two n-alkanes.. Vet Anaesth Analg 2017 May;44(3):577-588.
- Brosnan RJ, Pham TL. Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation.. BMC Pharmacol Toxicol 2014 Nov 19;15:62.
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