Injection of platelet- and leukocyte-rich plasma at the junction of the proximal sesamoid bone and the suspensory ligament branch for treatment of yearling Thoroughbreds with proximal sesamoid bone inflammation and associated suspensory ligament branch desmitis.
Abstract: To determine the effects of treatment with platelet- and leukocyte-rich plasma (PRP) on future 2-, 3-, and 4-year-old racing performance of yearling Thoroughbreds with proximal sesamoid bone inflammation and associated suspensory ligament branch (SLB) desmitis. Methods: Randomized clinical trial. Methods: 39 yearling Thoroughbreds. Methods: Yearling Thoroughbreds with radiographic evidence of performance-limiting proximal sesamoid bone inflammation and ultrasonographic evidence of associated SLB desmitis were identified and randomly assigned to undergo PRP (treatment group) or saline (0.9% NaCl) solution (control group) injection at the affected SLB-proximal sesamoid bone junction. Race records of horses for the 2-, 3-, and 4-year-old racing years were obtained. Data regarding amount of money earned and number of races started were used as outcome measures, and results for groups were compared. Results: Horses treated with PRP were significantly more likely to start at least 1 race during the 2-year-old racing year than were horses treated with saline solution; no significant differences were detected between groups regarding that variable for the 3- and 4-year-old racing years. No significant differences between groups were detected regarding earnings for any racing year. Conclusions: Although PRP-treated horses were more likely to start a race during the 2-year-old racing year versus control group horses, results for horses in each group were not significantly different for the 3- and 4-year-old racing years. Therefore, the PRP treatment protocol evaluated in this study did not seem to improve future racing performance of yearling Thoroughbreds with proximal sesamoid bone inflammation and associated SLB desmitis, compared with injection of saline solution.
Publication Date: 2013-06-22 PubMed ID: 23786200DOI: 10.2460/javma.243.1.120Google Scholar: Lookup
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- Journal Article
- Randomized Controlled Trial
- Research Support
- Non-U.S. Gov't
Summary
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The research study investigates the impact of platelet- and leukocyte-rich plasma (PRP) injection as a treatment for young Thoroughbred horses suffering from inflammation in the proximal sesamoid bone and suspensory ligament branch desmitis, and their subsequent racing performance. The study found that while PRP treatment seemingly boosted chances of Thoroughbreds racing in their second year, it showed no substantial benefit for horses in the third and fourth years.
Methodology
- This research was constituted as a randomized clinical trial involving 39 Thoroughbred yearlings.
- The horses had radiographically detected proximal sesamoid bone inflammation and ultrasonographic proof of associated suspensory ligament branch desmitis.
- The diagnosed horses were randomly assigned for treatment with either PRP (treatment group) or saline solution (control group) injected at the inflamed area of suspensory ligament branch and sesamoid bone junction.
- Data from race records of treated horses for the 2-, 3-, and 4-year-old racing seasons were compiled.
- The amount of money earned and number of races they participated in were used as performance outcome measures and this data for the two groups was compared.
Results
- Horses treated with PRP showed a significantly higher probability of participating in at least one race during their second year of racing as compared to the saline solution treated horses.
- No significant difference was found between the two groups for participation in races during the third and fourth year of racing seasons.
- When it comes to their earnings from these races, no notable differences were found between the two groups in any racing season.
Conclusions
- Although PRP treatment appeared to enhance the chances of Thoroughbreds racing in their second year, it showed no significant benefits for the third and fourth years.
- The results suggest that the method of PRP treatment doesn’t seem to enhance the future racing performance of Thoroughbred yearlings suffering from proximal sesamoid bone inflammation and suspensory ligament branch desmitis, when compared with an injection of saline solution.
Cite This Article
APA
Garrett KS, Bramlage LR, Spike-Pierce DL, Cohen ND.
(2013).
Injection of platelet- and leukocyte-rich plasma at the junction of the proximal sesamoid bone and the suspensory ligament branch for treatment of yearling Thoroughbreds with proximal sesamoid bone inflammation and associated suspensory ligament branch desmitis.
J Am Vet Med Assoc, 243(1), 120-125.
https://doi.org/10.2460/javma.243.1.120 Publication
Researcher Affiliations
- Rood and Riddle Equine Hospital, Lexington, KY 40580, USA. kgarrett@roodandriddle.com
MeSH Terms
- Aging
- Animals
- Bone Diseases / therapy
- Bone Diseases / veterinary
- Female
- Foot Bones
- Horse Diseases / therapy
- Horses
- Inflammation / therapy
- Inflammation / veterinary
- Leukocytes
- Ligaments
- Male
- Platelet-Rich Plasma
- Running
- Sports
Citations
This article has been cited 7 times.- Franini A, Entani MG, Colosio E, Melotti L, Patruno M. Case report: Flexor carpi ulnaris tendinopathy in a lure-coursing dog treated with three platelet-rich plasma and platelet lysate injections.. Front Vet Sci 2023;10:1003993.
- Nakajima K. Arthroscopic Autologous Bone Grafting for Hallux Sesamoid Fracture Nonunion Results in a High Rate of Complete Resolution.. Arthrosc Sports Med Rehabil 2022 Oct;4(5):e1789-e1797.
- Camargo Garbin L, Lopez C, Carmona JU. A Critical Overview of the Use of Platelet-Rich Plasma in Equine Medicine Over the Last Decade.. Front Vet Sci 2021;8:641818.
- Montano C, Auletta L, Greco A, Costanza D, Coluccia P, Del Prete C, Meomartino L, Pasolini MP. The Use of Platelet-Rich Plasma for Treatment of Tenodesmic Lesions in Horses: A Systematic Review and Meta-Analysis of Clinical and Experimental Data.. Animals (Basel) 2021 Mar 12;11(3).
- Radtke AV, Goodale MB, Fortier LA. Platelet and Leukocyte Concentration in Equine Autologous Conditioned Plasma Are Inversely Distributed by Layer and Are Not Affected by Centrifugation Rate.. Front Vet Sci 2020;7:173.
- Watts AE, Millar NL, Platt J, Kitson SM, Akbar M, Rech R, Griffin J, Pool R, Hughes T, McInnes IB, Gilchrist DS. MicroRNA29a Treatment Improves Early Tendon Injury.. Mol Ther 2017 Oct 4;25(10):2415-2426.
- Brossi PM, Moreira JJ, Machado TS, Baccarin RY. Platelet-rich plasma in orthopedic therapy: a comparative systematic review of clinical and experimental data in equine and human musculoskeletal lesions.. BMC Vet Res 2015 Apr 22;11:98.
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