Insulin and glucose regulation.
Abstract: Abnormally high or low blood glucose and insulin concentrations after standardized glucose tolerance tests can reflect disorders such as pituitary dysfunction, polysaccharide storage myopathies, and other clinical disorders. Glucose and insulin responses, however, are modified by the diet to which the animal has adapted, time since it was last fed, and what it was fed. Body fat (obesity), fitness level, physiologic status, and stress also alter glucose and insulin metabolism. Therefore, it is important to consider these factors when evaluating glucose and insulin tests, especially if only one sample it taken. This article describes the factors affecting glucose and insulin metabolism in horses and how they might influence the interpretation of standardized tests of glucose tolerance.
Publication Date: 2005-01-08 PubMed ID: 15635909DOI: 10.1016/s0749-0739(02)00014-7Google Scholar: Lookup
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Summary
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This research focuses on factors that impact glucose and insulin metabolism in horses, and how these influencing elements could potentially have an effect on the results of standardized tests for glucose tolerance.
Understanding Glucose and Insulin Regulation
- The research examines the abnormal levels of blood glucose and insulin concentrations that occur after standardized glucose tolerance tests. These abnormalities can indicate a variety of disorders, including pituitary dysfunctions and polysaccharide storage myopathies, among others.
- The study suggests that the metabolism of glucose and insulin is influenced by several factors such as the diet of the horse, the time since it was last fed, and what it was fed. These factors are known to modify the glucose and insulin responses in the horse.
Consideration of Other Factors
- Apart from diet and feeding time, other factors such as body fat (obesity), fitness level, physiological status, and stress levels can also impact glucose and insulin metabolism in horses. The research highlights the need to consider these factors when conducting and interpreting glucose and insulin tests.
- One-time sampling can also contribute to varying interpretations of test results, further substantiating the need to consider multiple factors while evaluating results.
Application of the Research
- This study elaborates on the factors that affect glucose and insulin metabolism in horses and offers insights on how these factors might influence the interpretation of standardized glucose tolerance tests.
- Considering these factors that can alter glucose and insulin metabolism, researchers, veterinarians, or testers could potentially achieve more accurate results or interpretations when evaluating glucose and insulin tests.
Cite This Article
APA
Ralston SL.
(2005).
Insulin and glucose regulation.
Vet Clin North Am Equine Pract, 18(2), 295-vii.
https://doi.org/10.1016/s0749-0739(02)00014-7 Publication
Researcher Affiliations
- Department of Animal Science, Cook College, Rutgers--the State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901, USA. Ralston@aesop.rutgers.edu
MeSH Terms
- Animals
- Blood Glucose / metabolism
- Circadian Rhythm / physiology
- Glucose Tolerance Test / veterinary
- Horse Diseases / diagnosis
- Horse Diseases / metabolism
- Horses / metabolism
- Insulin / metabolism
Citations
This article has been cited 8 times.- Warnken T, Schaub C, Delarocque J, Frers F, Feige K, Sonntag J, Reiche DB. Palatability, glycemic, and insulinemic responses to various carbohydrate formulations: Alternatives for the diagnosis of insulin dysregulation in horses?. J Vet Intern Med 2023 Jan;37(1):282-291.
- Spears JW, Lloyd KE, Siciliano P, Pratt-Phillips S, Goertzen EW, McLeod SJ, Moore J, Krafka K, Hyda J, Rounds W. Chromium propionate increases insulin sensitivity in horses following oral and intravenous carbohydrate administration.. J Anim Sci 2020 Apr 1;98(4).
- Norkaew T, Brown JL, Bansiddhi P, Somgird C, Thitaram C, Punyapornwithaya V, Punturee K, Vongchan P, Somboon N, Khonmee J. Influence of season, tourist activities and camp management on body condition, testicular and adrenal steroids, lipid profiles, and metabolic status in captive Asian elephant bulls in Thailand.. PLoS One 2019;14(3):e0210537.
- Kenéz Á, Warnken T, Feige K, Huber K. Lower plasma trans-4-hydroxyproline and methionine sulfoxide levels are associated with insulin dysregulation in horses.. BMC Vet Res 2018 May 2;14(1):146.
- Warnken T, Delarocque J, Schumacher S, Huber K, Feige K. Retrospective analysis of insulin responses to standard dosed oral glucose tests (OGTs) via naso-gastric tubing towards definition of an objective cut-off value.. Acta Vet Scand 2018 Jan 19;60(1):4.
- Morfeld KA, Brown JL. Metabolic health assessment of zoo elephants: Management factors predicting leptin levels and the glucose-to-insulin ratio and their associations with health parameters.. PLoS One 2017;12(11):e0188701.
- Warnken T, Huber K, Feige K. Comparison of three different methods for the quantification of equine insulin.. BMC Vet Res 2016 Sep 9;12(1):196.
- Giri JK, Magdesian KG, Gaffney PM. Insulin-dependent diabetes mellitus associated with presumed autoimmune polyendocrine syndrome in a mare.. Can Vet J 2011 May;52(5):506-12.
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