Insulin and glucose response following oral glucose administration in well-conditioned ponies.
Abstract: Twenty-three well-conditioned ponies were evaluated for insulin and glucose response following oral glucose administration (1 g/kg bodyweight [bwt] as a 20 per cent solution). Ponies were defined as normal if total insulin secretion (TIS) was less than 149 mu iu/ml h and the glucose concentration was below 11.1 +/- 0.11 mmol/litre (200 +/- 2 mg/dl) at all times following oral glucose administration. When glucose concentrations were maintained below 11.1 +/- 0.11 mmol/litre, the area under the glucose curve (TG) was less than 17.4 mmol/litre/h (314 mg/dl/h). The ponies were assigned to four groups based on insulin and glucose response: Group 1 (n = 7), normal; Group 2 (n = 5), high insulin, normal glucose; Group 3 (n = 8), high insulin, high glucose and Group 4 (n = 3), high glucose, normal insulin. This classification is an initial attempt to define normal insulin and glucose response in ponies. Additional data need to be accumulated to define further insulin resistance and diabetes in ponies.
Publication Date: 1992-02-01 PubMed ID: 9109953DOI: 10.1111/j.2042-3306.1992.tb04764.xGoogle Scholar: Lookup
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- Comparative Study
- Journal Article
Summary
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This research examined the insulin and glucose response to oral glucose intake in healthy ponies. The aim is to establish a norm for insulin and glucose response in ponies, which could help in the future to identify insulin resistance and diabetes in these animals.
Research Objective and Methodology
- The research sought to establish the normal insulin and glucose response levels in well-conditioned (healthy) ponies following an oral glucose test (OGTT). The OGTT, a standard test for assessing insulin function and glucose tolerance in humans, was administered to the ponies at 1 g/kg of body weight.
- Twenty-three ponies were involved in the study and they were classified into four categories based on their insulin and glucose responses to the OGTT. The categorization was a part of the effort to define what counts as a normal insulin and glucose response in ponies, which would enhance the understanding of insulin resistance and diabetes in ponies.
Finding and Analysis
- In the study, ponies were categorized as normal if their Total Insulin Secretion (TIS) was less than 149 μIU/mL/h and the glucose concentration was below 11.1 ± 0.11 mmol/litre at all times after oral glucose intake.
- When glucose concentrations were kept below 11.1 ± 0.11 mmol/litre, the Total Glucose (TG) area under the curve, a common way to measure blood glucose levels over time, was less than 17.4 mmol/litre/h.
- The ponies were then divided into four groups based on their insulin and glucose responses: Group 1, consisting of 7 ponies, showed normal responses; Group 2 showed high insulin and normal glucose responses in 5 ponies; Group 3 showed both high insulin and high glucose levels in 8 ponies; and Group 4 showed high glucose and normal insulin levels in 3 ponies. These variations could help differentiate between healthy response and potential insulin resistance in ponies.
Implication of the Study
- This classification and establishment of normative data provide a preliminary idea about insulin and glucose response in ponies. It offers a starting point to recognize abnormal insulin and glucose responses which may signify insulin resistance or diabetes.
- The researchers acknowledged the need for additional data, as these initial findings represent a first step towards understanding insulin resistance and diabetes in ponies. More research would refine and expand this foundational knowledge.
Cite This Article
APA
Freestone JF, Shoemaker K, Bessin R, Wolfsheimer JK.
(1992).
Insulin and glucose response following oral glucose administration in well-conditioned ponies.
Equine Vet J Suppl(11), 13-17.
https://doi.org/10.1111/j.2042-3306.1992.tb04764.x Publication
Researcher Affiliations
- Department of Veterinary Clinical Sciences, Louisiana State University, Baton Rouge 70803-8422, USA.
MeSH Terms
- Administration, Oral
- Analysis of Variance
- Animals
- Blood Glucose / analysis
- Blood Specimen Collection / veterinary
- Dexamethasone / administration & dosage
- Glucose / administration & dosage
- Glucose / pharmacology
- Glucose Tolerance Test / veterinary
- Horses / metabolism
- Hydrocortisone / blood
- Injections, Intramuscular / veterinary
- Insulin / metabolism
- Insulin Secretion
- Physical Conditioning, Animal / physiology
Citations
This article has been cited 2 times.- Wallis N, Raffan E. The Genetic Basis of Obesity and Related Metabolic Diseases in Humans and Companion Animals. Genes (Basel) 2020 Nov 20;11(11).
- d' Fonseca NMM, Gibson CME, van Doorn DA, de Ruijter-Villani M, Stout TAE, Roelfsema E. Effect of long-term overfeeding of a high-energy diet on glucose tolerance in Shetland pony mares. J Vet Intern Med 2020 May;34(3):1339-1349.
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