Integration of genomic information into sport horse breeding programs for optimization of accuracy of selection.
Abstract: Reliable selection criteria are required for young riding horses to increase genetic gain by increasing accuracy of selection and decreasing generation intervals. In this study, selection strategies incorporating genomic breeding values (GEBVs) were evaluated. Relevant stages of selection in sport horse breeding programs were analyzed by applying selection index theory. Results in terms of accuracies of indices (r(TI) ) and relative selection response indicated that information on single nucleotide polymorphism (SNP) genotypes considerably increases the accuracy of breeding values estimated for young horses without own or progeny performance. In a first scenario, the correlation between the breeding value estimated from the SNP genotype and the true breeding value (= accuracy of GEBV) was fixed to a relatively low value of r(mg) = 0.5. For a low heritability trait (h(2) = 0.15), and an index for a young horse based only on information from both parents, additional genomic information doubles r(TI) from 0.27 to 0.54. Including the conventional information source 'own performance' into the before mentioned index, additional SNP information increases r(TI) by 40%. Thus, particularly with regard to traits of low heritability, genomic information can provide a tool for well-founded selection decisions early in life. In a further approach, different sources of breeding values (e.g. GEBV and estimated breeding values (EBVs) from different countries) were combined into an overall index when altering accuracies of EBVs and correlations between traits. In summary, we showed that genomic selection strategies have the potential to contribute to a substantial reduction in generation intervals in horse breeding programs.
Publication Date: 2012-10-04 PubMed ID: 23031511DOI: 10.1017/S1751731112000626Google Scholar: Lookup
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- Evaluation Study
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The study focuses on integrating genomic information in horse breeding programs to better select young riding horses. The researchers are trying to improve genetic gain by using these selection criteria which might ultimately reduce generation intervals.
Context and Objective
- The study addresses the need for reliable selection criteria for young riding horses, with the goal of optimizing accuracy of selection and decrease generation intervals. The concept explored is potential genetic gain achieved by incorporating genomic breeding values (GEBVs) into selection strategies for sport horse breeding programs.
- The objective of the research is to evaluate how these new selection strategies impact the accuracy of estimated breeding values for young horses, considering factors like single nucleotide polymorphism (SNP) genotype data and horse performance.
Methods and Scenarios
- The research team applied selection index theory to analyze relevant stages in horse breeding programs. They evaluated the impact of genomic data on the accuracy of breeding value estimates in different scenarios.
- The first scenario considered a low positive correlation (r(mg) = 0.5) between the breeding value estimated from SNP genotype against the actual true breeding value (accuracy of GEBV). This was examined for a low heritability trait (h(2) = 0.15) in a young horse with only information from both parents considered.
- The second scenario involved including ‘own performance’ as a conventional information source in the mentioned index, in addition to SNP information.
Findings and Significance
- The researchers found that incorporating genomic information could potentially double the accuracy of estimated breeding values from 0.27 to 0.54. Including a horse’s performance data, in combination with SNP, information could further increase this accuracy by 40%.
- This research is significant because it illustrates how genomic information can be utilized in decision-making early in a horse’s life, particularly in traits with low heritability. This could therefore help to improve genetic gain and reduce generation intervals in horse breeding programs.
- In another approach, the team also evaluated how utilizing different sources of breeding values (e.g. Estimated Breeding Values (EBVs) from different countries and GEBVs) into an overall index might impact accuracy when altering correlations between traits and accuracies of EBVs. This suggested that using multiple sources of breeding values could be beneficial.
Cite This Article
APA
Haberland AM, König von Borstel U, Simianer H, König S.
(2012).
Integration of genomic information into sport horse breeding programs for optimization of accuracy of selection.
Animal, 6(9), 1369-1376.
https://doi.org/10.1017/S1751731112000626 Publication
Researcher Affiliations
- Department of Animal Sciences, University of Goettingen, 37075 Goettingen, Germany. ahaberl@gwdg.de
MeSH Terms
- Animals
- Breeding / methods
- Gait
- Genetic Predisposition to Disease
- Genome
- Genotype
- Horse Diseases / genetics
- Horses / genetics
- Horses / physiology
- Models, Biological
- Osteochondrosis / genetics
- Osteochondrosis / veterinary
- Polymorphism, Single Nucleotide
- Selection, Genetic
Citations
This article has been cited 9 times.- Nolte W, Alkhoder H, Wobbe M, Stock KF, Kalm E, Vosgerau S, Krattenmacher N, Thaller G, Tetens J, Kühn C. Replacement of microsatellite markers by imputed medium-density SNP arrays for parentage control in German warmblood horses. J Appl Genet 2022 Dec;63(4):783-792.
- Doyle JL, Carroll CJ, Corbally AF, Fahey AG. An overview of international genetic evaluations of show jumping in sport horses. Transl Anim Sci 2022 Apr;6(2):txac038.
- Vosgerau S, Krattenmacher N, Falker-Gieske C, Seidel A, Tetens J, Stock KF, Nolte W, Wobbe M, Blaj I, Reents R, Kühn C, von Depka Prondzinski M, Kalm E, Thaller G. Genetic and genomic characterization followed by single-step genomic evaluation of withers height in German Warmblood horses. J Appl Genet 2022 May;63(2):369-378.
- Büttgen L, Geibel J, Simianer H, Pook T. Simulation Study on the Integration of Health Traits in Horse Breeding Programs. Animals (Basel) 2020 Jul 7;10(7).
- Navas González FJ, Jordana Vidal J, León Jurado JM, McLean AK, Pizarro Inostroza G, Delgado Bermejo JV. Genetic parameter estimation and implementation of the genetic evaluation for gaits in a breeding program for assisted-therapy in donkeys. Vet Res Commun 2018 Jun;42(2):101-110.
- Lewczuk D, Borowska A, Andruszkiewicz J, Bagnicka E. Comparative Analysis of the Stallion Field Performance Test at Different Training Stages and Horse Age. Animals (Basel) 2025 Nov 13;15(22).
- Ziadi C, Valera M, Laseca N, Perdomo-González D, Demyda-Peyrás S, de Los Terreros AR, Molina A. Enhanced Reliability of the Evaluation of Fertility Traits in Pura Raza Española Horses Using Single-Step Genomic Best Linear Unbiased Prediction. Genes (Basel) 2025 May 9;16(5).
- Asti V, Summer A, Ablondi M, Sartori C, Giontella A, Pilastro V, Mecocci S, Cappelli K, Mancin E, Oian A, Mantovani R, Capomaccio S, Sabbioni A. Selection signatures and inbreeding: exploring genetic diversity in five native horse breeds. BMC Vet Res 2025 May 16;21(1):346.
- Ziadi C, Demyda-Peyrás S, Valera M, Perdomo-González D, Laseca N, Rodríguez-Sainz de Los Terreros A, Encina A, Azor P, Molina A. Comparative Analysis of Genomic and Pedigree-Based Approaches for Genetic Evaluation of Morphological Traits in Pura Raza Española Horses. Genes (Basel) 2025 Jan 23;16(2).
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