Interspecies comparison of subchondral bone properties important for cartilage repair.
Abstract: Microfracture repair tissue in young adult humans and in rabbit trochlea is frequently of higher quality than in corresponding ovine or horse models or in the rabbit medial femoral condyle (MFC). This may be related to differences in subchondral properties since repair is initiated from the bone. We tested the hypothesis that subchondral bone from rabbit trochlea and the human MFC are structurally similar. Trochlea and MFC samples from rabbit, sheep, and horse were micro-CT scanned and histoprocessed. Samples were also collected from normal and lesional areas of human MFC. The subchondral bone of the rabbit trochlea was the most similar to human MFC, where both had a relatively thin bone plate and a more porous and less dense character of subchondral bone. MFC from animals all displayed thicker bone plates, denser and less porous bone and thicker trabeculae, which may be more representative of older or osteoarthritic patients, while both sheep trochlear ridges and the horse lateral trochlea shared some structural features with human MFC. Since several cartilage repair procedures rely on subchondral bone for repair, subchondral properties should be accounted for when choosing animal models to study and test procedures that are intended for human cartilage repair.
© 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
Publication Date: 2014-09-19 PubMed ID: 25242685DOI: 10.1002/jor.22740Google Scholar: Lookup
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- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research examines the structural similarities between subchondral bone in rabbit trochlea and human medial femoral condyle (MFC). The study confirms a resemblance, suggesting potential implications for studying and testing cartilage repair procedures.
Study Objective and Hypothesis
- The aim of this research was to examine the structural similarities between subchondral bone from rabbit trochlea and human MFC.
- The researchers hypothesized that the subchondral bone of the rabbit trochlea would be the most structurally similar to that of the human MFC.
Research Methodology
- To test their hypothesis, researchers collected trochlea and MFC samples from rabbits, sheep, and horses. These samples were then scanned using micro-Computed Tomography (micro-CT) and subsequently histoprocessed.
- For comparison, samples were collected from normal and lesional areas of human MFC.
Findings
- The researchers found that the subchondral bone of the rabbit trochlea was indeed the most similar to the human MFC, as they both have a relatively thin bone plate and a porous, less dense character of subchondral bone.
- The MFC from other animals studied all displayed thicker bone plates, denser and less porous bone, along with thicker trabeculae. These characteristics may be more representative of older or osteoarthritic patients.
- The study also highlighted that while both sheep trochlear ridges and horse lateral trochlea shared some structural features with human MFC, they also differed in several significant respects.
Implications
- The study’s findings have potential implications for the study and testing of cartilage repair procedures, given that several such procedures rely on subchondral bone for repair.
- The researchers suggest that the subchondral properties of bone should be considered when selecting animal models for studying and testing procedures that are intended for human cartilage repair.
Cite This Article
APA
Chevrier A, Kouao AS, Picard G, Hurtig MB, Buschmann MD.
(2014).
Interspecies comparison of subchondral bone properties important for cartilage repair.
J Orthop Res, 33(1), 63-70.
https://doi.org/10.1002/jor.22740 Publication
Researcher Affiliations
- Chemical Engineering Department, Ecole Polytechnique de Montreal, PO Box 6079, Succ Centre-Ville, Montreal, Q, Canada, H3C 3A7.
MeSH Terms
- Adult
- Animals
- Bone Density / physiology
- Bone and Bones / anatomy & histology
- Bone and Bones / diagnostic imaging
- Bone and Bones / physiology
- Cadaver
- Cartilage, Articular / anatomy & histology
- Cartilage, Articular / diagnostic imaging
- Cartilage, Articular / physiology
- Female
- Femur / anatomy & histology
- Femur / diagnostic imaging
- Femur / physiology
- Fractures, Bone / physiopathology
- Horses
- Humans
- Male
- Models, Animal
- Rabbits
- Sheep
- Species Specificity
- Tomography, X-Ray Computed
- Wound Healing / physiology
Grant Funding
- Canadian Institutes of Health Research
Citations
This article has been cited 18 times.- Pohlig F, Wittek M, VON Thaden A, Lenze U, Glowalla C, Minzlaff P, Burgkart R, Prodinger PM. Biomechanical Properties of Repair Cartilage Tissue Are Superior Following Microdrilling Compared to Microfracturing in Critical Size Cartilage Defects.. In Vivo 2023 Mar-Apr;37(2):565-573.
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- Liu H, Ding Q, Ma C, Qin H, Wei Y, Ren Y. [Comparison of two methods for preparing knee osteochondral injury models in mice].. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jul 15;35(7):862-867.
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