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Equine veterinary journal2008; 40(4); 342-347; doi: 10.2746/042516408X293529

Large colon resection and anastomosis in horses: 52 cases (1996-2006).

Abstract: Large colon resection and anastomosis (LCRA) is the most aggressive method of surgical management of a colon with questionable viability. Currently, published studies are comprised mostly of broodmares and discuss short-term survival. Objective: To determine the prognosis for survival after LCRA in a diverse population of horses, report the incidence of post operative complications, and determine if associations between analysed variables and survival rate exist. Methods: The medical records of 52 horses that underwent LCRA were evaluated. Data were used to identify univariable associations with survival as well as complications related to LCRA. Chi-square, odds ratio with 95% confidence interval, Mann-Whitney or Kruskal-Wallis tests were used, with significance set at P<0.05. Results: Forty-four horses (84.6%) survived anaesthesia and recovery, 30 (57.7%) survived to be discharged from the hospital. Of the variables analysed, heart rate 24 h after recovery was significantly associated with mortality, as were endotoxaemia, ileus and peritonitis experienced post operatively. Conclusions: Heart rate 24 h after recovery may be a more reliable prognostic indicator than other analysed variables. Survival rate and complications after LCRA were similar to those previously reported.
Publication Date: 2008-03-07 PubMed ID: 18321811DOI: 10.2746/042516408X293529Google Scholar: Lookup
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  • Journal Article

Summary

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This research studied the survival rate and complications in horses undergoing large colon resection and anastomosis (LCRA), an aggressive surgical method, and identified that heart rate 24 hours after recovery, along with certain post-operative conditions, are significantly associated with mortality.

Methodology

  • The study was based on the medical records of 52 horses that underwent LCRA.
  • The data from these records were assessed to identify univariable associations with survival as well as complications related to the surgical procedure.
  • Various statistical testing methods such as Chi-square, odds ratio with a 95% confidence interval, Mann-Whitney or Kruskal-Wallis tests were used to ascertain the significance of the findings.

Results

  • Out of the 52 horses that underwent LCRA, 44 (84.6%) survived anaesthesia and initial recovery, while 30 (57.7%) survived long enough to be discharged from the hospital.
  • The study found that the horse’s heart rate as measured 24 hours after recovery is significantly associated with mortality. This suggests it may serve as a reliable indicator of a horse’s post-operation prognosis.
  • Other factors significantly linked to mortality were post-operative conditions such as endotoxaemia (toxins in the blood), ileus (a disruption in the normal movement of the digestive tract), and peritonitis (inflammation of the lining of the abdominal cavity).

Conclusions

  • The study concluded that a horse’s heart rate 24 hours post-recovery may be a more reliable prognostic indicator than other variables analysed in the study.
  • The research also found that the survival rate and complications seen after LCRA in the study subjects were similar to those reported in prior studies, suggesting consistency in the outcomes observed over multiple examinations.

Cite This Article

APA
Driscoll N, Baia P, Fischer AT, Brauer T, Klohnen A. (2008). Large colon resection and anastomosis in horses: 52 cases (1996-2006). Equine Vet J, 40(4), 342-347. https://doi.org/10.2746/042516408X293529

Publication

ISSN: 0425-1644
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 40
Issue: 4
Pages: 342-347

Researcher Affiliations

Driscoll, N
  • Chino Valley Equine Hospital, 2945 English Place, Chino Hills, CA 917109, USA.
Baia, P
    Fischer, A T
      Brauer, T
        Klohnen, A

          MeSH Terms

          • Anastomosis, Surgical / adverse effects
          • Anastomosis, Surgical / methods
          • Anastomosis, Surgical / veterinary
          • Animals
          • Colon / surgery
          • Colonic Diseases / mortality
          • Colonic Diseases / surgery
          • Colonic Diseases / veterinary
          • Female
          • Heart Rate / physiology
          • Horse Diseases / mortality
          • Horse Diseases / surgery
          • Horses
          • Male
          • Manometry / veterinary
          • Postoperative Complications / epidemiology
          • Postoperative Complications / mortality
          • Postoperative Complications / veterinary
          • Pressure
          • Prognosis
          • Retrospective Studies
          • Survival Analysis
          • Treatment Outcome

          Citations

          This article has been cited 6 times.
          1. Gozalo-Marcilla M, Ringer SK. Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature. Animals (Basel) 2021 Jun 14;11(6).
            doi: 10.3390/ani11061777pubmed: 34198637google scholar: lookup
          2. Lambertini C, Zannoni A, Romagnoli N, Bombardi C, Morini M, Dondi F, Bernardini C, Forni M, Rinnovati R, Spadari A. Expression of Proteinase-Activated Receptor 2 During Colon Volvulus in the Horse. Front Vet Sci 2020;7:589367.
            doi: 10.3389/fvets.2020.589367pubmed: 33330716google scholar: lookup
          3. Gonzalez LM, Baker WT, Hughes FE, Blikslager AT, Fogle CA. Comparison of histomorphometric characteristics of dorsal colon and pelvic flexure biopsy specimens obtained from horses with large colon volvulus that underwent resection. Am J Vet Res 2020 Nov;81(11):899-903.
            doi: 10.2460/ajvr.81.11.899pubmed: 33107753google scholar: lookup
          4. Orr KE, Baker WT, Lynch TM, Hughes FE, Clark CK, Slone DE Jr, Fogle CA, Gonzalez LM. Prognostic value of colonic and peripheral venous lactate measurements in horses with large colon volvulus. Vet Surg 2020 Apr;49(3):472-479.
            doi: 10.1111/vsu.13361pubmed: 31916608google scholar: lookup
          5. Salem SE, Hough R, Probert C, Maddox TW, Antczak P, Ketley JM, Williams NJ, Stoneham SJ, Archer DC. A longitudinal study of the faecal microbiome and metabolome of periparturient mares. PeerJ 2019;7:e6687.
            doi: 10.7717/peerj.6687pubmed: 30976468google scholar: lookup
          6. Gonzalez LM, Fogle CA, Baker WT, Hughes FE, Law JM, Motsinger-Reif AA, Blikslager AT. Operative factors associated with short-term outcome in horses with large colon volvulus: 47 cases from 2006 to 2013. Equine Vet J 2015 May;47(3):279-84.
            doi: 10.1111/evj.12273pubmed: 24735170google scholar: lookup